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Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. Additionally we are shipping Insulinoma-Associated 1 Proteins (4) and Insulinoma-Associated 1 Kits (3) and many more products for this protein.
Showing 10 out of 16 products:
Human Polyclonal INSM1 Primary Antibody for WB - ABIN2779789
Breslin, Zhu, Lan: NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system. in The Journal of biological chemistry 2003
Human Polyclonal INSM1 Primary Antibody for EIA, WB - ABIN499952
Lan, Li, Lu, Modi, Notkins: Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1. in The Journal of biological chemistry 1994
results reveal that IA1 constitutes a novel player downstream of Xash1 (show ASCL1 Antibodies) in the formation of a previously unidentified population of Xenopus noradrenergic primary neurons
Data supports our hypothesis that a positive-feedback loop of sonic hedgehog (show SHH Antibodies) signaling induced INSM1 through N-myc (show MYCN Antibodies) and INSM1 enhanced N-myc (show MYCN Antibodies) stability contributing to the transformation of human neuroblastoma (show ARHGEF16 Antibodies).
Small cell lung cancer tissues were strongly positive for INSM1. INSM1 signal was not detected on normal adjacent tissues from lung cancer patients or normal lung tissues
the INSM1-promoter specific conditional replicating adenovirus represents a sensitive diagnostic tool to aid clinicians in the detection of NE tumors.
Insulinoma-Associated Protein 1 is a crucial regulator of neuroendocrine differentiation in lung cancer.
INSM1 autoantibodies were associated with risk of developing type 1 diabetes.
INSM1 expression was significantly increased in Neuroendocrine neoplastic vs nonneoplastic tissue.
Both the AR42J cell line and the primary cultured mouse acinar cells support role for INSM1 in pancreatic acinar cell trans-differentiation model.
The results suggest that INSM1 up-regulation plays a positive role in HSV-1 replication, probably by binding to the ICP0 promoter.
The INSM1 promoter can direct herpes simplex virus thymidine kinase (show TK1 Antibodies) gene expression in a nude mouse model of neuroendocrine cancer and effectively repress tumor growth in response to ganciclovir treatment.
Data show that the consistent functional effect of INSM1, either with or without other ITFs, promotes pancreatic duct cell differentiation as well as induces Panc-1 cell cycle arrest.
INSM1 ectopic expression impairs normal lung development especially in postnatal alveologenesis.
Insm1 is the earliest known gene expressed in outer versus inner hair cells, demonstrating that nascent outer hair cells initiate a unique differentiation program in the embryo, much earlier than previously believed.
Insm1-dependent Hes1 repression is required for neuroendocrine development.
INSM1 interacts with RACK1 (show GNB2L1 Antibodies) protein and facilitates insulin receptor (show INSR Antibodies) -mediated signaling.
Insm1 works to promote endocrine cell differentiation in a pathway that involves Neurog3 and Ripply3
Data suggest that IA-2 (show PTPRN Antibodies) and IA-2beta (show PTPRN2 Antibodies) play important roles in regulation of circadian rhythm, likely through neurochemical communication among neurons of suprachiasmatic nucleus. [Insm2 (show INSM2 Antibodies)-beta; IA-2beta (show PTPRN2 Antibodies); insulinoma-associated protein 2 (show INSM2 Antibodies)-beta]
Insm1 acts in the epigenetic and transcriptional network that controls differentiation of endocrine cells in the anterior pituitary gland, and that it requires the SNAG domain to exert this function in vivo.
This study suggested that Insm1 in promoting the transition of progenitors from apical and proliferative to basal, terminal and neuronogenic.
isolation, characterization, and identification of an interacting protein, Cbl (show CBL Antibodies)-associated protein (CAP)
IA-1 gene is developmentally expressed in the nervous system and the NeuroD1 (show NEUROD1 Antibodies)/E47 (show TCF3 Antibodies) transcription factors up-regulate IA-1 gene expression through the proximal E-box element of the IA-1 promoter
characterization of two zebrafish Insm1-like genes, insm1a and insm1b, and analysis of their expression patterns during embryonic development
Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.
, insuloma-associated 1
, insulinoma-associated protein 1
, zinc finger protein IA-1
, insulinoma-associated protein (IA-1)
, insulinoma-associated 1-like protein b