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The protein encoded by IL10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. Additionally we are shipping IL-10 Antibodies (697) and IL-10 Kits (260) and many more products for this protein.
Showing 10 out of 165 products:
Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN2666701
Asadullah, Sterry, Volk: Interleukin-10 therapy--review of a new approach. in Pharmacological reviews 2003
Show all 6 references for ABIN2666701
Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305073
Howard, OGarra, Ishida, de Waal Malefyt, de Vries: Biological properties of interleukin 10. in Journal of clinical immunology 1992
Show all 4 references for ABIN1305073
Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN413418
van der Vliet, Wang, Yue, Koon, Balk, Exley: Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells. in Journal of immunology (Baltimore, Md. : 1950) 2008
Show all 3 references for ABIN413418
Cat (Feline) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN2008820
Yoon, Jones, Logsdon, Walter: Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain. in Structure (London, England : 1993) 2005
Show all 3 references for ABIN2008820
Wild boar (Sus scrofa) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN2008795
Gesser, Leffers, Jinquan, Vestergaard, Kirstein, Sindet-Pedersen, Jensen, Thestrup-Pedersen, Larsen: Identification of functional domains on human interleukin 10. in Proceedings of the National Academy of Sciences of the United States of America 1998
Show all 2 references for ABIN2008795
Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305072
Vieira, de Waal-Malefyt, Dang, Johnson, Kastelein, Fiorentino, deVries, Roncarolo, Mosmann, Moore: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. in Proceedings of the National Academy of Sciences of the United States of America 1991
Show all 2 references for ABIN1305072
Rat (Rattus) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN2009133
Cui, Feng, Wang, Zhao: [Expression of RhoA in the lung tissue of acute lung injury rats and the influence of RhoA on the expression of IL-8 and IL-10]. in Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2011
IL10 SNPs are not associated with liver graft rejection.
IL-10- 1082A/G polymorphism is associated with an increased risk for coronary artery disease.
this meta-analysis shows that IL-10 genetic polymorphisms are associated with altered non-Hodgkin lymphoma susceptibility, especially for Caucasians
The IL-10 -1082A/G (rs1800896) genotype is associated with an increased susceptibility and worse outcome for osteosarcoma patients in the Chinese Han population.
Our results suggest that the polymorphism at position -1082 in the promoter region of IL-10 may affect serum HDL (show HSD11B1 Proteins) and TG concentrations, while other variants of this gene appear to have no relationship with serum lipoprotein levels
The results of this study indicate that the IL-10 -1082G/A polymorphism might be a risk factor for asthma in children. However, because of the small sample size included in the subgroup analyses, the results should be interpreted with caution
IL-10 polymorphisms are associated with hepatitis B virus infection.
IL-4 (show IL4 Proteins) (intron 3) and IL-10 (-1082) gene polymorphisms are not significantly associated with susceptibility to rheumatic heart disease, but they might play a role in the pathogenesis of patients with mitral valve disease.
Data indicate that microRNA miR (show MLXIP Proteins)-410 is the key regulatory factor in the pathogenesis of systemic lupus erythematosus (SLE) by regulating the expression of IL-10 through targeting STAT3 (show STAT3 Proteins).
Correlation between IL10 genetic variation and plasma levels of sHLA-G in schizophrenia patients.
It has been demonstrated that beta-endorphin (show POMC Proteins) stimulates the zymosan-induced secretion of reactive oxygen species and suppresses the spontaneous production of IL-1beta (show IL1B Proteins) and IL-10 by murine peritoneal macrophages in vivo.
the degree of fibrosis, inflammatory cell infiltration, and the number of BM-derived myofibroblasts were significantly different between IL-10 KO BM and WT BM transplanted mice, highlighting a likely role of IL-10 in pancreatitis.
CD26 (show DPP4 Proteins) costimulatory blockade promotes lung allograft acceptance via reduced T cell infiltration, less expression of IL-17 (show IL17A Proteins), and increased expression of IL-10, likely to be derived from alternatively activated macrophages.
Lactobacillus curvatus WiKim38 induced significantly higher levels of IL-10 in bone marrow-derived dendritic cells.
Light-emitting diode therapy increased the levels of IL-10 in a model of chronic inflammatory hyperalgesia
NAD (+) regulates Treg conversion into Th17 cells and promotes homeostasis through IL-10
Inhibition of Interleukin-10 Signaling Induces Microbiota-dependent Chronic Colitis in Apolipoprotein E (show APOE Proteins) Deficient Mice.
Melatonin upregulates the expression of IL-10 in the spleen and reduce the severity of experimental autoimmune encephalomyelitis
Low-level stress resulted in a marked increase in the expression of the antiinflammatory cytokine IL-10 in wild-type but not BDNF (show BDNF Proteins)-deficient mice
Antiplatelet effects of clopidogrel are not significantly different between mice with and without IL-10 gene expression, although systemic exposure to clopidogrel active metabolite is significantly higher in IL-10 KO mice than in WT mice.
This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.
IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.
Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll (show TLR4 Proteins) like receptor activation.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3 (show SOCS3 Proteins), which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (show TH1L Proteins) biased, interferon-gamma (show IFNG Proteins) production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.
serum IL-6 (show IL6 Proteins):IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (show IL6 Proteins), IL-10 and TNF-alpha (show TNF Proteins), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
The complete open reading frame consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10.
ICAM1 (show ICAM1 Proteins) and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 (show JUN Proteins) may be responsible for this upregulation.
These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (show TGFB1 Proteins), IL-10, and IL-6 (show IL6 Proteins) in ovarian follicles are reported.
Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma (show IFNG Proteins)+CD4 (show CD4 Proteins)+ regulatory T cells to control transplant arteriosclerosis.
Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK (show MAPK14 Proteins) activation.
Boar seminal plasma contained TGF- beta1 (show TGFB1 Proteins) and IL-10 but with high individual variation.
Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.
These results suggest that TNF-alpha (show TNF Proteins) and IL-10, but not IL-6 (show IL6 Proteins), are involved in the late reparatory phases of the experimental disk lesion.
The present study shows that elevated levels of serum CRP (show CRP Proteins) and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)
Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.
Twenty one polymorphisms in the IL10 gene have been found, including single nucleotide polymorphisms and insertion deletion polymorphisms. The chromosomal location has been mapped by FISH and radiation hybrid mapping.
IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS (show NTS Proteins), which may contribute to differences in the clinical presentation of NTS (show NTS Proteins) infection in the setting of malaria.
Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.
IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha (show TNF Proteins) cytokine production.
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
T-cell growth inhibitory factor
, cytokine synthesis inhibitory factor
, uncharacterized protein LOC100715618
, Cytokine synthesis inhibitory factor