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Interleukin 10 Proteins (IL10)

The protein encoded by IL10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. Additionally we are shipping IL-10 Antibodies (641) and IL-10 Kits (288) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IL10 3586 P22301
IL10 16153 P18893
Rat IL10 IL10 25325 P29456
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Top IL-10 Proteins at

Showing 10 out of 172 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 50 μg Log in to see 2 to 3 Days
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   10 μg Log in to see 5 to 6 Days
HOST_Escherichia coli (E. coli) Rat Un-conjugated 10 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 μg Log in to see 5 to 6 Days
HOST_Escherichia coli (E. coli) Cat Un-conjugated 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Wild boar Un-conjugated 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 10 to 12 Days

IL10 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , , ,
, , ,
Mouse (Murine) , ,

Rat (Rattus) , ,

Top referenced IL-10 Proteins

  1. Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN2666701 : Asadullah, Sterry, Volk: Interleukin-10 therapy--review of a new approach. in Pharmacological reviews 2003 (PubMed)
    Show all 6 references for ABIN2666701

  2. Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305073 : Howard, OGarra, Ishida, de Waal Malefyt, de Vries: Biological properties of interleukin 10. in Journal of clinical immunology 1992 (PubMed)
    Show all 4 references for ABIN1305073

  3. Cat (Feline) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN2008820 : Yoon, Jones, Logsdon, Walter: Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain. in Structure (London, England : 1993) 2005 (PubMed)
    Show all 3 references for ABIN2008820

  4. Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN413418 : van der Vliet, Wang, Yue, Koon, Balk, Exley: Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)
    Show all 3 references for ABIN413418

  5. Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN2003641 : Gesser, Leffers, Jinquan, Vestergaard, Kirstein, Sindet-Pedersen, Jensen, Thestrup-Pedersen, Larsen: Identification of functional domains on human interleukin 10. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Show all 2 references for ABIN2003641

  6. Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305072 : Vieira, de Waal-Malefyt, Dang, Johnson, Kastelein, Fiorentino, deVries, Roncarolo, Mosmann, Moore: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)
    Show all 2 references for ABIN1305072

  7. Rat (Rattus) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN2009133 : Cui, Feng, Wang, Zhao: [Expression of RhoA in the lung tissue of acute lung injury rats and the influence of RhoA on the expression of IL-8 and IL-10]. in Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2011 (PubMed)

More Proteins for Interleukin 10 (IL10) Interaction Partners

Human Interleukin 10 (IL10) interaction partners

  1. a protective role of mutant alleles G and A in IL-10-1082A/G and IL-13 (show IL13 Proteins)+2044G/A against gliomas.

  2. The data indicate that IL-10 polymorphism G-1082A may be involved in the pathogenesis of chronic lymphoid leukemia.

  3. Specific IL-10 variants (rs3024490, rs1800872, and rs1800871) and haplotype (GTCCA and TGATG) may contribute to the development of cervical cancer among Tunisian women

  4. Data show that the high intensity interval exercise (HIIE) induced decrease in interleukin-8 (IL-8 (show IL8 Proteins)) levels 30min post session and a progressive elevation in interleukin-10 (IL-10) levels immediately and 30min post in lean and overweight-obese.

  5. Patients with gastric cancer (GC) have significantly higher IL-6 (show IL6 Proteins) levels, and lower IL-8 (show IL8 Proteins) and IL-10 concentrations, in comparison to controls and patients with other gastric neoplasms

  6. the results of our study suggested an association between the IL-10- 1082A/G gene polymorphisms and an elevated risk of coronary artery disease

  7. IL-10 rs1800896 was correlated with an increased risk of acute pancreatitis in codominant, dominant, and recessive models.

  8. Analysis of peripheral leucocytes, eosinophils, immunoglobulin E, and IL-4 (show IL4 Proteins) and IL-10 concentrations presented significantly higher values in children with radiologically confirmed liver granuloma than in uncomplicated hepatomegaly.

  9. Patients with occupational allergic dermatoses showed significantly higher frequency of polymorphic variants of cytokine genes IL4 (show IL4 Proteins) C589T, IL10 C819T, IL10 G1082A, IL10 C592A, and TNF (show TNF Proteins) G308A in comparison with the population control.

  10. IL-10 -592A/C (rs1800872) polymorphism was associated with an increased risk of early-onset preeclampsia in a Chinese population

Mouse (Murine) Interleukin 10 (IL10) interaction partners

  1. IFN-gamma (show IFNG Proteins)-treated mesenchymal stem cells strongly inhibit IL-10 production by activated B cells by a mechanism requiring cell contact and involving the Cox-2 pathway.

  2. results suggest that CDK5 (show CDK5 Proteins) enhances the inflammatory function of macrophages by inhibiting the MAPK (show MAPK1 Proteins)-dependent production of IL-10.

  3. The relative severity of T. muris infection in IL-10 knockout mice that were treated with metronidazole, prednisolone, or IL-10 is reported.

  4. Studied DC-specific TLR4 (show TLR4 Proteins) signaling on host defense against intra-abdominal polymicrobial sepsis; found TLR4 (show TLR4 Proteins) deletion on DCs was associated with lower levels of IL-10, higher PMN (show TBCE Proteins) accumulation in the peritoneal cavity, and higher expression of CXCR2 (show CXCR2 Proteins).

  5. IL-10 is critical to restraining autoantibody production and surprisingly plays a vital role in supporting the expansion of innate-like populations.

  6. A rare but potent B-cell subset in both humans and mice is capable of inhibiting immune responses through the production of the anti-inflammatory cytokine IL-10. (Review)

  7. Identify a specific LN-derived B2-B(reg (show KCNH2 Proteins)) subset that confers IL-10 mediated protection from neointima formation.

  8. Il10(-/-) Treg cells showed reduced steady-state Foxp3 (show FOXP3 Proteins) expression, and polyclonal stimulation caused greater loss of Foxp3 (show FOXP3 Proteins)

  9. This study represents the first experimental characterization of the IL-10.GAG complex structure and provides the starting point for revealing the biological significance of the interaction of IL-10 with GAGs.

  10. IL-10 counteracts both the pressoric activity of Ang II (show AGT Proteins) as well as vascular dysfunction associated with hypertension, partially, modulating the RhoA (show RHOA Proteins)-Rho kinase (show ROCK2 Proteins) pathway.

Cow (Bovine) Interleukin 10 (IL10) interaction partners

  1. This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.

  2. IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.

  3. Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll (show TLR4 Proteins) like receptor activation.

  4. Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3 (show SOCS3 Proteins), which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.

Horse (Equine) Interleukin 10 (IL10) interaction partners

  1. The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.

  2. The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (show TH1L Proteins) biased, interferon-gamma (show IFNG Proteins) production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.

  3. serum IL-6 (show IL6 Proteins):IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia

  4. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (show IL6 Proteins), IL-10 and TNF-alpha (show TNF Proteins), in horses with recurrent airway obstruction during exacerbation and in remission is reported.

Rabbit Interleukin 10 (IL10) interaction partners

  1. ICAM1 (show ICAM1 Proteins) and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 (show JUN Proteins) may be responsible for this upregulation.

Pig (Porcine) Interleukin 10 (IL10) interaction partners

  1. These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.

  2. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (show TGFB1 Proteins), IL-10, and IL-6 (show IL6 Proteins) in ovarian follicles are reported.

  3. Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma (show IFNG Proteins)+CD4 (show CD4 Proteins)+ regulatory T cells to control transplant arteriosclerosis.

  4. Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK (show MAPK14 Proteins) activation.

  5. Boar seminal plasma contained TGF- beta1 (show TGFB1 Proteins) and IL-10 but with high individual variation.

  6. Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.

  7. These results suggest that TNF-alpha (show TNF Proteins) and IL-10, but not IL-6 (show IL6 Proteins), are involved in the late reparatory phases of the experimental disk lesion.

  8. The present study shows that elevated levels of serum CRP (show CRP Proteins) and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)

  9. Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.

  10. Twenty one polymorphisms in the IL10 gene have been found, including single nucleotide polymorphisms and insertion deletion polymorphisms. The chromosomal location has been mapped by FISH and radiation hybrid mapping.

Rhesus Monkey Interleukin 10 (IL10) interaction partners

  1. IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS (show NTS Proteins), which may contribute to differences in the clinical presentation of NTS (show NTS Proteins) infection in the setting of malaria.

  2. Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.

  3. IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha (show TNF Proteins) cytokine production.

IL-10 (IL10) Protein Profile

Protein Summary

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Gene names and symbols associated with Interleukin 10 Proteins (IL10)

  • interleukin 10 (IL10)
  • interleukin 10 (Il10)
  • CSIF protein
  • GVHDS protein
  • Il-10 protein
  • IL10A protein
  • IL10X protein
  • TGIF protein

Protein level used designations for Interleukin 10 Proteins (IL10)

T-cell growth inhibitory factor , cytokine synthesis inhibitory factor , interleukin-10 , CSIF , IL-10 , uncharacterized protein LOC100715618 , Cytokine synthesis inhibitory factor , Interleukin-10

3586 Homo sapiens
16153 Mus musculus
25325 Rattus norvegicus
281246 Bos taurus
100034187 Equus caballus
443342 Ovis aries
403628 Canis lupus familiaris
428264 Gallus gallus
100860746 Capra hircus
100715618 Cavia porcellus
100008701 Oryctolagus cuniculus
397106 Sus scrofa
493683 Felis catus
694931 Macaca mulatta
100386149 Callithrix jacchus
469657 Pan troglodytes
101271889 Orcinus orca
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