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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Additionally we are shipping IL27 Antibodies (165) and IL27 Proteins (27) and many more products for this protein.
Showing 10 out of 48 products:
Human IL27 ELISA Kit for Sandwich ELISA - ABIN414441
Li, Zhang, Ge, Zhou, Qi, Ma, Xue, Zhou, Yang: Elevated interleukin-27 enhances the polarization of Th1/Tc1 cells and the production of proinflammatory cytokines in primary immune thrombocytopenia. in Human immunology 2012
Rat (Rattus) IL27 ELISA Kit for Sandwich ELISA - ABIN416127
Gao, Pang, Zhang, Li, Tu, Zhang, Niu, Xiong, Xiao, Zhao, Gao, Wang: Poria Attenuates Idiosyncratic Liver Injury Induced by Polygoni Multiflori Radix Praeparata. in Frontiers in pharmacology 2016
Human IL27 ELISA Kit for Sandwich ELISA - ABIN365220
Le Texier, Thebault, Carvalho-Gaspar, Vignard, Merieau, Usal, Cuturi, Wood, Chiffoleau: Immunoregulatory function of IL-27 and TGF-?1 in cardiac allograft transplantation. in Transplantation 2012
IL-27 stimulation activated STAT1 (show STAT1 ELISA Kits) and STAT3 (show STAT3 ELISA Kits) in HeLa and T98G cells, suggesting that IL-27 engages the STAT1 (show STAT1 ELISA Kits)/3 pathway, which then leads to the upregulation of IL-6 (show IL6 ELISA Kits), IP-10 (show CXCL10 ELISA Kits), and MIG (show CXCL9 ELISA Kits)
IL-27 and IL-37 limit the induction of particular T cell subsets along with cytokine responses in S. stercoralis infections, which suggest the importance of IL-27 and IL-37 in immune modulation in a chronic helminth infection.
IL-27 is a pivotal regulator in endometriotic immune tolerance by triggering Th17 cells to produce IL-10 (show IL10 ELISA Kits).
HIV and Tat (show TAT ELISA Kits) inhibit LPS (show IRF6 ELISA Kits)-induced IL-27 production in human macrophages via distinct mechanisms: Tat (show TAT ELISA Kits) through the inhibition of cIAP-1 (show BIRC2 ELISA Kits)-TRAF-6 (show TRAF6 ELISA Kits) and subsequent inhibition of PI3K (show PIK3CA ELISA Kits) and p38 (show CRK ELISA Kits) MAPKs, whereas HIV through the inhibition of p38 MAPK (show MAPK14 ELISA Kits) activation.
IL27 (show EBI3 ELISA Kits) recapitulates IFN-gamma (show IFNG ELISA Kits) responses in hepatocellular carcinoma cells, but is inhibited by IL6 (show IL6 ELISA Kits)-type cytokines.
These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta (show IL1B ELISA Kits) secretion levels triggered by dual LPS (show IRF6 ELISA Kits)-ATP stimulation.
IL-27 enhanced the cytotoxicity and suppressed the proliferation of ovarian cancer cells
Study of the expression of IL-17 (show IL17A ELISA Kits) provides theoretical support for the clinical treatment and prognosis prediction of ovarian epithelial tumor.
the sIL (show PMEL ELISA Kits)-6R/p28 (show PSMD10 ELISA Kits) fusion protein (FP) upregulated IFN-lambda1 expression by increasing the binding abilities of c-Fos and activating transcription factor 1 (show AFT1 ELISA Kits) to the IFN-lambda1 promoter via the p38 MAPK (show MAPK14 ELISA Kits) signaling pathway; results demonstrate the important role of sIL (show PMEL ELISA Kits)-6R/p28 (show PSMD10 ELISA Kits) FP in mediating virus-induced type III IFN production.
These results identify IL-27 and its specific receptor IL27RA (show IL27RA ELISA Kits) as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection.
found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 (show IL6 ELISA Kits) is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27
We demonstrate that IL-27-deficiency is linked to increased mucosal presence of ILC2 in a model of inflammatory lung disease. Moreover, IL-27-treatment inhibited ILC2 proliferation and cytokine production and significantly reduced their accumulation in vivo.
These data suggest a novel role of the sympathetic neuroendocrine system for the modulation of IL-27-dependent acute inflammation.
results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.
These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta (show IL1B ELISA Kits) secretion levels triggered by dual LPS (show TLR4 ELISA Kits)-ATP stimulation.
findings show that PGE2 inhibits IL-27 production in macrophages and in splenic conventional dendritic cells; and identify a novel pathway consisting of signaling through EP2/EP4-->induction of cAMP-->downregulation of IFN regulatory factor 1 expression and binding to the p28 IFN-stimulated response element site
these data provide the first evidence that IL-27 signals directly to B (show TDO2 ELISA Kits) cells promote GCs (show UGCG ELISA Kits) and support the role of IL-27 in lupus.
this study shows that IL-27 plays an important role in immune response and pathogen clearance during infection with Candida parapsilosis
Inhibition of IL-27p28 also enhanced the suppressive capacity of adoptively transferred CD4 (show CD4 ELISA Kits)(+) nTregs by increasing the stability of Foxp3 (show FOXP3 ELISA Kits) expression.
These data provide evidence of a central role of IL-27 for the control of Th2-mediated allergic diseases.
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
, IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interleukin 27 p28 subunit
, interluekin 27