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In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Additionally we are shipping IL27 Receptor alpha Proteins (14) and IL27 Receptor alpha Kits (2) and many more products for this protein.
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Human Polyclonal IL27 Receptor alpha Primary Antibody for IHC, ELISA - ABIN1003238
Sprecher, Grant, Baumgartner, Presnell, Schrader, Yamagiwa, Whitmore, OHara, Foster: Cloning and characterization of a novel class I cytokine receptor. in Biochemical and biophysical research communications 1998
Show all 2 references for ABIN1003238
Human Polyclonal IL27 Receptor alpha Primary Antibody for IHC, ELISA - ABIN1003239
Chen, Ghilardi, Wang, Baker, Xie, Gurney, Grewal, de Sauvage: Development of Th1-type immune responses requires the type I cytokine receptor TCCR. in Nature 2000
Show all 2 references for ABIN1003239
Findings demonstrated that IL-27 (show IL27 Antibodies) and IL-27R were elevated in multiple sclerosis lesions and that local IL-27 (show IL27 Antibodies) can modulate immune properties of astrocytes and infiltrating immune cells
The significant expression of IL-27 (show IL27 Antibodies) in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor (show EBI3 Antibodies) pair is detrimental in TB.
natural sIL (show PMEL Antibodies)-27Ralpha binds rIL (show PDLIM4 Antibodies)-27, inhibits IL-27 (show IL27 Antibodies) binding to its cell surface receptor, and is a potent inhibitor of IL-27 (show IL27 Antibodies) signaling, as shown by its ability to specifically block IL-27 (show IL27 Antibodies)-mediated STAT (show STAT1 Antibodies) activation, at low molar excess over IL-27 (show IL27 Antibodies).
Aberrant hypermethylation and reduced expression of IL27RA is associated with myelodysplastic syndromes.
TCCR/WSX-1 is closely associated with angiogenesis and could serve as a novel therapeutic target in patients with age-related macular degeneration.
Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity.
WSX-1 is essential for transcriptional activation of STAT1 (show STAT1 Antibodies) and for augmenting the induction of T-bet expression during initiation of Th1 (show TH1L Antibodies) cell differentiation.
WSX-1 together with the cytokine receptor (show EBI3 Antibodies) gp130 (show IL6ST Antibodies) constitutes a functional signal-transducing receptor for IL-27 (show IL27 Antibodies).
IL-27R possesses hematopoietic cell-transforming properties
These results indicate that humanin protects neurons by binding to a complex or complexes involving CNTFR (show CNTFR Antibodies)/WSX-1/gp130 (show IL6ST Antibodies).
The combination of mutant p53 (show TP53 Antibodies) & IL27RA(-/-) causes spontaneous liver inflammation, steatosis, and fibrosis, whereas either gene alone has no effects on the liver.
IL-10 (show IL10 Antibodies) production by CD4 (show CD4 Antibodies)(+) YFP(+) T cells is controlled systemically during malaria infection through IL-27 (show IL27 Antibodies) receptor signaling that is supported after CD4 (show CD4 Antibodies)(+) T cell priming by ICOS (show ICOS Antibodies) signaling.
The significant expression of IL-27 (show IL27 Antibodies) in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor (show LEPR Antibodies) pair is detrimental in TB.
IL-27R-mediated regulation of IL-17 (show IL17A Antibodies) controls the development of respiratory syncytial virus-associated pathogenesis.
CCL4 (show CCL4 Antibodies) and CCL5 (show CCL5 Antibodies) expression was higher in livers of infected WSX-1(-/-) mice than infected WT mice, and hepatic CD4 (show CD4 Antibodies) T cells from WSX-1(-/-) mice expressed higher levels of CCR5 (show CCR5 Antibodies) than cells from WT mice
The loss of IL-27R signaling across the whole mouse resulted in reduced viral control and a slight increase in the number of virus-specific CD4 (show CD4 Antibodies) T cells at early stages of viral infection.
Diminution of the Th1 (show HAND1 Antibodies) response in infected Il27ra mice in vivo by neutralization of IL-12p40 attenuated CCR5 (show CCR5 Antibodies) expression.
These findings establish a novel antiatherogenic role for IL-27 (show IL27 Antibodies) receptor signaling, which acts to suppress the production of proinflammatory cytokines and chemokines and to curb the recruitment of inflammatory myeloid cells into atherosclerotic aortas.
In Th1 (show HAND1 Antibodies)-dependent autoinflammatory lesions, IL-27Ralpha has a biphasic role in vivo, initially pathogenic, but ultimately playing a protective role by regulating immune responses and attenuating disease.
Data show that the deletion of Il27ra ameliorates pathology in the pristane-induced SLE model.
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.
interleukin 27 receptor, alpha
, class I cytokine receptor
, interleukin-27 receptor subunit alpha
, type-I T cell cytokine receptor
, IL-27 receptor subunit alpha
, IL-27R subunit alpha
, T-cell cytokine receptor type 1
, cytokine receptor WSX-1
, cytokine receptor-like 1
, type I T-cell cytokine receptor
, T cell cytokine receptor
, T cell cytokine receptor; cytokine receptor family, class 1 (WSXWS), member 1
, cytokine receptor family, class 1 (WSXWS), member 1