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IL28B encodes a cytokine distantly related to type I interferons and the IL-10 family. Additionally we are shipping Interleukin 28B (Interferon, lambda 3) Kits (19) and Interleukin 28B (Interferon, lambda 3) Proteins (12) and many more products for this protein.
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Human Polyclonal IL28B Primary Antibody for EIA, WB - ABIN952885
Lindh, Lagging, Norkrans, Hellstrand: Observed and calculated interleukin-28B genotype frequencies in hepatitis C virus infection. in Hepatology (Baltimore, Md.) 2010
Show all 4 references for ABIN952885
IL-28B down-regulates Tregs following subunit vaccine ESAT6-Ag85B-Mpt64(190-198)-Mtb8.4-HspX (show HSP Antibodies) vaccination but does not improve the protective immune responses.
the role of IFN-lambda in IDO (show IDO1 Antibodies) regulation was investigated after influenza infection of respiratory epithelial cells.
Data indicate that rotavirus infection induces production of interferon (show IFNA Antibodies)-lambda (IFN-lambda) and interleukin 22 (IL-22 (show IL22 Antibodies)) by intestinal epithelial cells.
Acritical role of IL-28 cytokines is in controlling T cell responses in vivo through the modulation of lung CD11c (show ITGAX Antibodies)(+) DC function in experimental allergic asthma.
IFN-alpha (show IFNA Antibodies), IFN-beta (show IFNB1 Antibodies), and IFN-gamma (show IFNG Antibodies) were observed in the anterior segment of injected eyes through 72 hours and mRNA levels of IFN-beta (show IFNB1 Antibodies) and IFN-gamma (show IFNG Antibodies) were increased in virus-infected eyes 48 to 120 hours after herpes simplex infection
the duration of IFNlambda signaling to JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) is different from that of IFNalpha
intranasal influenza A virus infection leads to the robust type III IFN induction in the lungs of both WT and IFNAR (show IFNAR1 Antibodies)-/- mice
IL-28A (show IL28A Antibodies) emerges as a key regulatory cytokine with pathogenic function in T-cell-mediated liver injury
Type III interferon (show IFNA Antibodies)/IL-28 targets a specific subset of cells and contributes to the antiviral response evoked by Toll (show TLR4 Antibodies)-like receptors, largely mediated by inducing an antiviral state in epithelial cells.
IL-28B can induce 100% protection from mortality after a lethal influenza challenge
Results show that detection of SNPs in IL28B combined with increased IP-10 (show CXCL10 Antibodies) levels increase predictability of sustained virological Response in patients treated with pegylated interferon (show IFNA Antibodies) 2alpha a plus ribavirin.
In patients infected with HCV-3 [hepatitis-C virus genotype-3], IFNlambda3 [interferon lambda-3] rs12979860, SNP[ single nucleotide polymorphisms ] has less impact on SVR [sustained virologic response ].
the association of amino acid substitutions in the HCV core protein and the IFNL3 and IFNL4 polymorphisms with the severity of liver disease, particularly in hepatocellular carcinoma development
IL28B and OAS (show SMOC1 Antibodies) polymorphisms are associated with different clinical outcomes in chronic hepatitis B children treated with interferon (show IFNA Antibodies).
There is no significant correlation between IL28B polymorphism and treatment response to IFNalpha.
unfavorable genotypes of IL28B gene rs12979860 and rs8099917 SNPs have no influence on the risk of progression to the end stage of liver disease in the Iranian population. In addition, there was no relationship between genotypes and serum level of IL28 with response to combination therapy.
this study shows that the IL28B gene polymorphism and serum levels play a role in the pathogenesis of Hashimoto's thyroiditis in Turkey
this study shows that the IL28B gene polymorphism may influence glucose homeostasis in Type 2 diabetes patients
Results identified three SNPs (S320F, H245Y, and H77Y) as highly deleterious in KIR2DL3 (show KIR2DL3 Antibodies) and nine SNPs (R157Q, H156Y, S63L, R157 W, F179 V, H128R, T101 M, R180C and F176I) in case of IFNL3, in coding region only with high conservation ranks highlighting the functional SNPs on phenotypic variability and disease susceptibility on HCV clearance candidate genes.
In hemodialysis patients, the IFNL3 polymorphisms do not affect development of antibodies to HBV surface antigen in response to HBV infection or vaccination, but might be involved in the resolution of HCV infection.
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
, interferon alpha
, interferon lambda-3
, interleukin 28
, cytokine Zcyto22
, interferon lambda-4
, interferon, lambda 4
, interleukin 28B (interferon, lambda 3)
, interleukin 28C