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IL28B encodes a cytokine distantly related to type I interferons and the IL-10 family. Additionally we are shipping Interleukin 28B (Interferon, lambda 3) Kits (23) and Interleukin 28B (Interferon, lambda 3) Proteins (14) and many more products for this protein.
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results suggest that IL-28B induces more mature NK cells to defend against viruses, in addition to its direct antiviral activity
IL-28B down-regulates Tregs following subunit vaccine ESAT6-Ag85B-Mpt64(190-198)-Mtb8.4-HspX (show HSP Antibodies) vaccination but does not improve the protective immune responses.
the role of IFN-lambda in IDO (show IDO1 Antibodies) regulation was investigated after influenza infection of respiratory epithelial cells.
Data indicate that rotavirus infection induces production of interferon (show IFNA Antibodies)-lambda (IFN-lambda) and interleukin 22 (IL-22 (show IL22 Antibodies)) by intestinal epithelial cells.
Acritical role of IL-28 cytokines is in controlling T cell responses in vivo through the modulation of lung CD11c (show ITGAX Antibodies)(+) DC function in experimental allergic asthma.
IFN-alpha (show IFNA Antibodies), IFN-beta (show IFNB1 Antibodies), and IFN-gamma (show IFNG Antibodies) were observed in the anterior segment of injected eyes through 72 hours and mRNA levels of IFN-beta (show IFNB1 Antibodies) and IFN-gamma (show IFNG Antibodies) were increased in virus-infected eyes 48 to 120 hours after herpes simplex infection
the duration of IFNlambda signaling to JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) is different from that of IFNalpha
intranasal influenza A virus infection leads to the robust type III IFN induction in the lungs of both WT and IFNAR (show IFNAR1 Antibodies)-/- mice
IL-28A (show IL28A Antibodies) emerges as a key regulatory cytokine with pathogenic function in T-cell-mediated liver injury
Type III interferon (show IFNA Antibodies)/IL-28 targets a specific subset of cells and contributes to the antiviral response evoked by Toll (show TLR4 Antibodies)-like receptors, largely mediated by inducing an antiviral state in epithelial cells.
The results obtained suggest that both studied IL28B gene SNPs (single nucleotide polymorphisms), as well as the IL10 (show IL10 Antibodies) gene rs1800872 SNP are associated with predisposition to tick-borne encephalitis in Russian population.
IL-28B genotyping may be useful for directing patients towards lower cost therapies, and rationing use of costly direct antivirals for use in those individuals showing genetic risk.
the IFNL3 rs 12979860 CC genotype may be negatively associated with hepatic steatosis in Asian chronic hepatitis C patients.
IL-28B rs12979860 genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients.
Data show that the genotype distributions of IFNL3 and IFNL4 variants (rs4803217, rs368234815, rs117648444, and rs12979860) were in Hardy-Weinberg equilibrium.
In Taiwan, chronic hepatitis C (CHC (show CLTC Antibodies)) patients have a lower frequency of favorable IL28B TT genotype than healthy controls. Among patients with CHC (show CLTC Antibodies), the frequency of TT genotype is higher in HCV genotype 2 patients than in HCV genotype 1 patients. In addition, CHC (show CLTC Antibodies) patients with TT genotype, particularly females, have a lower likelihood of advanced fibrosis.
IFNL3 SNPs genotyped have shown no association with ribavirin treatment in hepatitis C patients with genotype 3.
monocytes from carriers of an IL-28B T/T genotype display a reduced ability to stimulate NK cell activity
alterations in IL28B SNP genotype may occur after living donor liver transplantation, leading to modifications in the host genome or donor proteome by HCV.
Results show that detection of SNPs in IL28B combined with increased IP-10 (show CXCL10 Antibodies) levels increase predictability of sustained virological Response in patients treated with pegylated interferon (show IFNA Antibodies) 2alpha a plus ribavirin.
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
, interferon alpha
, interferon lambda-3
, interleukin 28
, cytokine Zcyto22
, interferon lambda-4
, interferon, lambda 4
, interleukin 28B (interferon, lambda 3)
, interleukin 28C