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CTIF is a component of the CBP80 (NCBP1\; MIM 600469)/CBP20 (NCBP2\; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. Additionally we are shipping KIAA0427 Antibodies (8) and many more products for this protein.
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association of SNPs in LCP1 (show LCP1 Proteins) and CTIF with hearing
Study reveals that Ago2 (show EIF2C2 Proteins), but not Ago2F2V2, inhibits the binding of CBP80 (show NCBP1 Proteins)/20 to cap structure.
a new MIF4G domain-containing protein (show MIF4GD Proteins), CTIF that interacts directly with CBP80 (show NCBP1 Proteins) and is part of the CBP80 (show NCBP1 Proteins)/20-dependent translation initiation complex [CBP80/20-dependent translation initiation factor, CTIF]
CTIF is a component of the CBP80 (NCBP1\; MIM 600469)/CBP20 (NCBP2\; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009