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Karyopherin (Importin) beta 1 (KPNB1) ELISA Kits

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. Additionally we are shipping KPNB1 Antibodies (66) and KPNB1 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human KPNB1 KPNB1 3837 Q14974
Anti-Mouse KPNB1 KPNB1 16211 P70168
Anti-Rat KPNB1 KPNB1 24917 P52296
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More ELISA Kits for KPNB1 Interaction Partners

Xenopus laevis Karyopherin (Importin) beta 1 (KPNB1) interaction partners

  1. The Importin beta-dependent nuclear import of TopBP1 (show TOPBP1 ELISA Kits) was required for the mitomycin C -induced Chk1 (show CHEK1 ELISA Kits) phosphorylation.

  2. Data show that importin-beta binds to Apc (show APC ELISA Kits) and negatively regulates the MT-assembly and spindle-promoting activity of Apc (show APC ELISA Kits) in a Ran-regulatable manner.

  3. The initial step of chromatin seeding is negatively regulated by importin beta.

Human Karyopherin (Importin) beta 1 (KPNB1) interaction partners

  1. Patients with tumors highly expressing Kpnbeta1 have poorer overall survivals. Kpnbeta1 interacts with p65 (show GORASP1 ELISA Kits) and enhances cell adhesion-mediated drug resistance.

  2. Collectively, these data show that KPNB1 is required for timely nuclear import of PER/CRY (show CRY2 ELISA Kits) in the negative feedback regulation of the circadian clock.

  3. Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3 (show IGFBP3 ELISA Kits)) and Regulates Its Interaction with Importin-beta.

  4. RBBP4 (show RBBP4 ELISA Kits) functions as a novel regulatory factor to increase the efficiency of importin alpha (show KPNA4 ELISA Kits)/beta-mediated nuclear import

  5. High expression of KPNB1 protein is associated with hepatocellular carcinoma.

  6. Data show that cytoskeleton associated protein 5 (chTOG (show CKAP5 ELISA Kits)) only weakly promotes importin (show KPNA4 ELISA Kits)-regulated microtubule nucleation, but acts synergistically with microtubule- associated protein TPX2 (show TPX2 ELISA Kits).

  7. Data reveal a novel role for miR (show MLXIP ELISA Kits)-9 in regulation of the NFAT (show NFATC1 ELISA Kits) pathway by targeting KPNB1 and DYRK1B (show DYRK1B ELISA Kits).

  8. Data show that importin-beta (impbeta) alters the nuclear pore's permeability in a Ran-dependent manner, suggesting that impbeta is a functional component of the nuclear pore complex (NPC (show NPC1 ELISA Kits)).

  9. DZNep suppressed EZH2 (show EZH2 ELISA Kits)/miR (show MLXIP ELISA Kits)-30a,d/KPNB1 signaling.

  10. Importin (show KPNA4 ELISA Kits) beta1 mediates the translocation of NF-kappaB (show NFKB1 ELISA Kits) into the nuclei of myeloma cells, thereby regulating proliferation and blocking apoptosis, which provides new insights for targeted myeloma therapies.

Mouse (Murine) Karyopherin (Importin) beta 1 (KPNB1) interaction partners

  1. KPNb1 acts as a positive regulator in the NF-kappaB (show NFKB1 ELISA Kits) pathway to enhance palmitate-induced inflammation response.

  2. KPNB1 may play a key role in the inflammation process of rheumatoid arthritis via STAT3 (show STAT3 ELISA Kits) signal transduction pathway.

  3. The study revealed a regulatory role of the p97-Npl4-Ufd1 complex in regulating a partial degradation of the NF-kappaB subunit p100.

  4. Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin (show HTT ELISA Kits) protein.

  5. translation of Importin (show KPNA4 ELISA Kits) beta1 mRNA enables separation of cytoplasmic and nuclear transport functions of importins and is required for efficient retrograde signaling in injured axons.

  6. A critical function of RanBP2 (show RANBP2 ELISA Kits) is to capture recycling RanGTP-importin-beta complexes at cytoplasmic fibrils to allow for adequate classical nuclear localization signal-mediated cargo import.

  7. Ap4A hydrolase (show NUDT2 ELISA Kits) was found to translocate into the nuclei of mast cells following immunological activation; found its immunologically dependent association with importin beta

  8. Data show that MRTF-A (show MKL1 ELISA Kits) contains an unusually long bipartite nuclear localisation signal embedded within the RPEL domain, that uses the importin (show KPNA4 ELISA Kits) (Imp (show BRAP ELISA Kits))alpha/beta-dependent import pathway, and that import is inhibited by G-actin (show ACTB ELISA Kits).

  9. results show the crystal structure of importin-beta complexed with the active form of SREBP-2 (show SREBF2 ELISA Kits)

  10. Results suggest that the importin alpha (show KPNA4 ELISA Kits)/beta system is involved in nuclear entry of mammalian clock components Cry2 (show CRY2 ELISA Kits) and Per2 (show PER2 ELISA Kits), which is indispensable to transcriptional oscillation of clock genes

KPNB1 Antigen Profile

Antigen Summary

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KPNB1

  • importin beta-1 subunit (AFUA_1G15720) antibody
  • importin beta-1 subunit (AOR_1_1974174) antibody
  • Importin beta-1 subunit (Bm1_57540) antibody
  • importin beta-1 subunit (PMAA_065830) antibody
  • importin beta-1 subunit (AFLA_083750) antibody
  • importin beta-1 subunit (TSTA_085870) antibody
  • importin beta-1 subunit (BDBG_07509) antibody
  • importin beta-1 subunit (MCYG_00039) antibody
  • karyopherin (importin) beta 1 (kpnb1) antibody
  • importin beta 1 (LOC100533387) antibody
  • karyopherin (importin) beta 1 (KPNB1) antibody
  • karyopherin (importin) beta 1 (Kpnb1) antibody
  • AA409963 antibody
  • Afu1g15720 antibody
  • AO090005001133 antibody
  • IMB1 antibody
  • Impnb antibody
  • IPO1 antibody
  • IPOB antibody
  • NTF97 antibody

Protein level used designations for KPNB1

Importin beta-1 subunit , importin beta-1 subunit , importin beta 1 , PTAC97 , importin 1 , importin 90 , importin subunit beta-1 , importin-90 , karyopherin subunit beta-1 , nuclear factor p97 , pore targeting complex 97 kDa subunit , SCG , importin beta , Importin beta , karyopherin,beta 1 , nuclear factor P97

GENE ID SPECIES
3509962 Aspergillus fumigatus Af293
5990046 Aspergillus oryzae RIB40
6106392 Brugia malayi
7023725 Talaromyces marneffei ATCC 18224
7910816 Aspergillus flavus NRRL3357
8104552 Talaromyces stipitatus ATCC 10500
8502478 Ajellomyces dermatitidis SLH14081
9223307 Arthroderma otae CBS 113480
100137718 Xenopus laevis
100533387 Aplysia californica
3837 Homo sapiens
491042 Canis lupus familiaris
507804 Bos taurus
16211 Mus musculus
24917 Rattus norvegicus
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