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Karyopherin (Importin) beta 1 Proteins (KPNB1)

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. Additionally we are shipping KPNB1 Antibodies (83) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KPNB1 3837 Q14974
KPNB1 16211 P70168
Rat KPNB1 KPNB1 24917 P52296
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Top KPNB1 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$498.21
Details
HOST_Sf-9 Cells Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$460.85
Details

KPNB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced KPNB1 Proteins

  1. Human KPNB1 Protein expressed in Escherichia coli (E. coli) - ABIN667986 : Moroianu, Blobel, Radu: Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes. in Proceedings of the National Academy of Sciences of the United States of America 1995 (PubMed)
    Show all 2 references for ABIN667986

More Proteins for Karyopherin (Importin) beta 1 (KPNB1) Interaction Partners

Xenopus laevis Karyopherin (Importin) beta 1 (KPNB1) interaction partners

  1. The Importin beta-dependent nuclear import of TopBP1 (show TOPBP1 Proteins) was required for the mitomycin C -induced Chk1 (show CHEK1 Proteins) phosphorylation.

  2. Data show that importin-beta binds to Apc (show APC Proteins) and negatively regulates the MT-assembly and spindle-promoting activity of Apc (show APC Proteins) in a Ran-regulatable manner.

  3. The initial step of chromatin seeding is negatively regulated by importin beta.

Human Karyopherin (Importin) beta 1 (KPNB1) interaction partners

  1. Patients with tumors highly expressing Kpnbeta1 have poorer overall survivals. Kpnbeta1 interacts with p65 (show GORASP1 Proteins) and enhances cell adhesion-mediated drug resistance.

  2. Collectively, these data show that KPNB1 is required for timely nuclear import of PER/CRY (show CRY2 Proteins) in the negative feedback regulation of the circadian clock.

  3. Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3 (show IGFBP3 Proteins)) and Regulates Its Interaction with Importin-beta.

  4. RBBP4 (show RBBP4 Proteins) functions as a novel regulatory factor to increase the efficiency of importin alpha (show KPNA4 Proteins)/beta-mediated nuclear import

  5. High expression of KPNB1 protein is associated with hepatocellular carcinoma.

  6. Data show that cytoskeleton associated protein 5 (chTOG) only weakly promotes importin-regulated microtubule nucleation, but acts synergistically with microtubule- associated protein TPX2.

  7. Data reveal a novel role for miR (show MLXIP Proteins)-9 in regulation of the NFAT (show NFATC1 Proteins) pathway by targeting KPNB1 and DYRK1B (show DYRK1B Proteins).

  8. Data show that importin-beta (impbeta) alters the nuclear pore's permeability in a Ran-dependent manner, suggesting that impbeta is a functional component of the nuclear pore complex (NPC (show NPC1 Proteins)).

  9. DZNep suppressed EZH2 (show EZH2 Proteins)/miR (show MLXIP Proteins)-30a,d/KPNB1 signaling.

  10. Importin (show KPNA4 Proteins) beta1 mediates the translocation of NF-kappaB (show NFKB1 Proteins) into the nuclei of myeloma cells, thereby regulating proliferation and blocking apoptosis, which provides new insights for targeted myeloma therapies.

Mouse (Murine) Karyopherin (Importin) beta 1 (KPNB1) interaction partners

  1. KPNb1 acts as a positive regulator in the NF-kappaB (show NFKB1 Proteins) pathway to enhance palmitate-induced inflammation response.

  2. KPNB1 may play a key role in the inflammation process of rheumatoid arthritis via STAT3 (show STAT3 Proteins) signal transduction pathway.

  3. The study revealed a regulatory role of the p97 (show EIF4G2 Proteins)-Npl4-Ufd1 (show UFD1L Proteins) complex in regulating a partial degradation of the NF-kappaB (show NFKB1 Proteins) subunit p100 (show PATL2 Proteins).

  4. Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin (show HTT Proteins) protein.

  5. translation of Importin (show KPNA4 Proteins) beta1 mRNA enables separation of cytoplasmic and nuclear transport functions of importins and is required for efficient retrograde signaling in injured axons.

  6. A critical function of RanBP2 is to capture recycling RanGTP-importin-beta complexes at cytoplasmic fibrils to allow for adequate classical nuclear localization signal-mediated cargo import.

  7. Ap4A hydrolase (show NUDT2 Proteins) was found to translocate into the nuclei of mast cells following immunological activation; found its immunologically dependent association with importin beta

  8. Data show that MRTF-A contains an unusually long bipartite nuclear localisation signal embedded within the RPEL domain, that uses the importin (show KPNA4 Proteins) (Imp (show BRAP Proteins))alpha/beta-dependent import pathway, and that import is inhibited by G-actin (show ACTB Proteins).

  9. results show the crystal structure of importin-beta complexed with the active form of SREBP-2 (show SREBF2 Proteins)

  10. Results suggest that the importin alpha (show KPNA4 Proteins)/beta system is involved in nuclear entry of mammalian clock components Cry2 (show CRY2 Proteins) and Per2 (show PER2 Proteins), which is indispensable to transcriptional oscillation of clock genes

KPNB1 Protein Profile

Protein Summary

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KPNB1

  • importin beta-1 subunit (AFUA_1G15720)
  • importin beta-1 subunit (AOR_1_1974174)
  • Importin beta-1 subunit (Bm1_57540)
  • importin beta-1 subunit (PMAA_065830)
  • importin beta-1 subunit (AFLA_083750)
  • importin beta-1 subunit (TSTA_085870)
  • importin beta-1 subunit (BDBG_07509)
  • importin beta-1 subunit (MCYG_00039)
  • karyopherin (importin) beta 1 (kpnb1)
  • importin beta 1 (LOC100533387)
  • karyopherin (importin) beta 1 (KPNB1)
  • karyopherin (importin) beta 1 (Kpnb1)
  • AA409963 protein
  • Afu1g15720 protein
  • AO090005001133 protein
  • IMB1 protein
  • Impnb protein
  • IPO1 protein
  • IPOB protein
  • NTF97 protein

Protein level used designations for KPNB1

Importin beta-1 subunit , importin beta-1 subunit , importin beta 1 , PTAC97 , importin 1 , importin 90 , importin subunit beta-1 , importin-90 , karyopherin subunit beta-1 , nuclear factor p97 , pore targeting complex 97 kDa subunit , SCG , importin beta , Importin beta , karyopherin,beta 1 , nuclear factor P97

GENE ID SPECIES
3509962 Aspergillus fumigatus Af293
5990046 Aspergillus oryzae RIB40
6106392 Brugia malayi
7023725 Talaromyces marneffei ATCC 18224
7910816 Aspergillus flavus NRRL3357
8104552 Talaromyces stipitatus ATCC 10500
8502478 Ajellomyces dermatitidis SLH14081
9223307 Arthroderma otae CBS 113480
100137718 Xenopus laevis
100533387 Aplysia californica
3837 Homo sapiens
491042 Canis lupus familiaris
507804 Bos taurus
16211 Mus musculus
24917 Rattus norvegicus
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