You are viewing an incomplete version of our website. Please click to reload the website as full version.

Kelch-Like ECH-Associated Protein 1 Proteins (KEAP1)

KEAP1 encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Additionally we are shipping Kelch-Like ECH-Associated Protein 1 Antibodies (141) and Kelch-Like ECH-Associated Protein 1 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KEAP1 9817 Q14145
KEAP1 50868 Q9Z2X8
KEAP1 117519  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Kelch-Like ECH-Associated Protein 1 Proteins at antibodies-online.com

Showing 8 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,804.17
Details
HOST_Escherichia coli (E. coli) Human S tag,His tag   100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Escherichia coli (E. coli) Mouse S tag,His tag   100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

KEAP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , , ,
Mouse (Murine)
,
Rat (Rattus)

Top referenced Kelch-Like ECH-Associated Protein 1 Proteins

  1. Human KEAP1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004959 : Strachan, Morgan, Otis, Caltagarone, Gittis, Bowser, Jordan-Sciutto: Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein. in Biochemistry 2004 (PubMed)
    Show all 4 references for ABIN2004959

  2. Human KEAP1 Protein expressed in Human - ABIN2724103 : Lieder, Reisen, Geppert, Sollberger, Beer, auf dem Keller, Schäfer, Detmar, Schneider, Werner: Identification of UV-protective activators of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) by combining a chemical library screen with computer-based virtual screening. in The Journal of biological chemistry 2012 (PubMed)
    Show all 2 references for ABIN2724103

  3. Human KEAP1 Protein expressed in Wheat germ - ABIN1308530 : Yuan, Ji, Luo, Lu, Ma, Ma, Chen: Quinone reductase (QR) inducers from Andrographis paniculata and identification of molecular target of andrographolide. in Fitoterapia 2012 (PubMed)

More Proteins for Kelch-Like ECH-Associated Protein 1 (KEAP1) Interaction Partners

Human Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. Immunohistochemical assays were used to measure the expression of Keap1 protein in breast cancer tissue and adjacent normal tissue, and its clinical significance was explored. We observed that 24.6% breast cancer tissue samples were positive for Keap1, a significantly lower proportion than that seen with adjacent normal tissue specimens

  2. c-myc (show MYC Proteins) plays a key role in MBD1 (show DPEP1 Proteins) mediated epigenetic silencing of KEAP1.

  3. Results show up-regulation of TrkB (show NTRK2 Proteins) and down-regulation of Runx3 (show RUNX3 Proteins) and Keap1 in breast cancer cells and suggest that TrkB (show NTRK2 Proteins) plays a key role in tumorigenicity and metastasis of breast cancer cells through suppression of Runx3 (show RUNX3 Proteins) or Keap1.

  4. Inhibition of NRF2 (show GABPA Proteins) by KEAP1 overexpression compromises metabolic reprogramming of fibroblasts and results in reduced efficiency of induced pluripotent stem cells colony formation.

  5. Induction of GSH-related genes xCT and GCLM (show GCLM Proteins) were oxygen and Bach1 (show BACH1 Proteins)-insensitive during long-term culture under 5% O2, providing the first evidence that genes related to GSH synthesis mediate protection afforded by Nrf2 (show GABPA Proteins)-Keap1 defense pathway

  6. Up-regulation of KEAP1 is associated with carcinogenesis and progression of Salivary Adenoid Cystic Carcinoma.

  7. Studies demonstrate that Keap1-Nrf2 (show GABPA Proteins) pathway is important to orchestrate an elaborate genetic program that enhances the intrinsic cytoprotective functions, including drug metabolizing, antioxidant and antiinflammatory networks. [review]

  8. Studies propose that Keap1 activity and Nrf2 (show GABPA Proteins) are regulated by interactions of Trx1 (show MLL Proteins) system enzymes with oxidants. [review]

  9. Accumulating evidence suggests that dysregulation of Keap1-Nrf2 (show GABPA Proteins) pathway resulting in constitutively active Nrf2 (show GABPA Proteins) and increased expression of cytoprotective Nrf2 (show GABPA Proteins) target genes, has a pivotal role in cancer. [review]

  10. expression of Nrf2 (show GABPA Proteins)-Keap1 is abnormal in osteosarcoma tissue and shows significant clinical relevance for determining the prognosis of osteosarcoma

Cow (Bovine) Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. the potency of 15d-PGJ2 as a signalling molecule (show GDF5 Proteins) in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin

Mouse (Murine) Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. Caffeic acid induces Nrf2 (show NFE2L2 Proteins) activation by decreasing the expression of its inhibitor protein Keap1 and blocking the binding of Nrf2 (show NFE2L2 Proteins) with Keap1.

  2. Hepatocyte-specific deletion of Keap1 triggering constitutive Nrf2 (show NFE2L2 Proteins) activation shifts hepatic metabolism towards increased lipid catabolism, reduced liponeogenesis and activation of the pentose phosphate pathway.

  3. findings reveal that Keap1 regulates cell migration by affecting the subcellular localization and activity of cortactin (show CTTN Proteins) independently of its role in oxidant stress responses.

  4. chronic hyperglycemic conditions, Keap1 inhibition increased Nrf2 (show NFE2L2 Proteins) nuclear translocation, increased antioxidant gene expression, and reduced ROS (show ROS1 Proteins) production to normoglycemic levels.

  5. conclusion, increased Keap1/Nrf2 (show NFE2L2 Proteins) signaling in the liver is accompanied by repressed gluconeogenesis and lipogenesis that can, at least partially, explain the ameliorated diabetic phenotype in the Keap1-hypo mice.

  6. Keap1 utilizes multiple cysteine residues specifically and/or collaboratively as sensors for the detection of a wide range of environmental stresses.

  7. iron deficiency induced the nuclear translocation of Nrf2 (show NFE2L2 Proteins) via Keap1 degradation by autophagy and subsequently upregulated expression of HO-1 (show HMOX1 Proteins).

  8. These results strongly suggest that p62 plays a crucial role in preventing fenofibrate-induced cell death.

  9. Keap1 knockdown caused severe disruption in both the redox cycle and the cell cycle of replicating hepatocytes.

  10. LXR (show NR1H3 Proteins) agonist can enhance the functional survival of transplanted AD-MSCs in infarcted myocardium, at least partially, via modulation of the TLR4 (show TLR4 Proteins)/NF-kappaB (show NFKB1 Proteins) and Keap-1/Nrf-2 (show NFE2L2 Proteins) signaling pathways.

Zebrafish Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2 (show NFE2L2 Proteins), indicating that the presence of either Cys (show DNAJC5 Proteins)-273 or Cys (show DNAJC5 Proteins)-288 is sufficient for fish Keap1 molecules to fully function

  2. study reports that the Keap1-Nrf2 (show NFE2L2 Proteins) system comprises discrete sensor sites, including the Keap1 cysteines Cys (show DNAJC5 Proteins)-151 and Cys (show DNAJC5 Proteins)-273, for a variety of Nrf2 (show NFE2L2 Proteins)-activating compounds

Kelch-Like ECH-Associated Protein 1 (KEAP1) Protein Profile

Protein Summary

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Gene names and symbols associated with KEAP1

  • kelch-like ECH-associated protein 1 (KEAP1)
  • kelch-like ECH-associated protein 1 (keap1)
  • kelch-like ECH-associated protein 1 (LOC100346935)
  • kelch-like ECH-associated protein 1 (Keap1)
  • Kelch-like ECH-associated protein 1 (Keap1)
  • kelch-like ECH-associated protein 1a (keap1a)
  • fb36f11 protein
  • Inrf2 protein
  • keap1 protein
  • KLHL19 protein
  • mKIAA0132 protein
  • wu:fb36f11 protein

Protein level used designations for KEAP1

kelch-like ECH-associated protein 1 , cytosolic inhibitor of Nrf2 , kelch-like family member 19 , kelch-like protein 19 , NRF2 cytosolic inhibitor , ring canal protein

GENE ID SPECIES
455706 Pan troglodytes
493386 Xenopus (Silurana) tropicalis
100346935 Oryctolagus cuniculus
9817 Homo sapiens
476713 Canis lupus familiaris
100136900 Sus scrofa
532791 Bos taurus
50868 Mus musculus
117519 Rattus norvegicus
496326 Xenopus laevis
100173389 Pongo abelii
321837 Danio rerio
Selected quality suppliers for Kelch-Like ECH-Associated Protein 1 Proteins (KEAP1)
Did you look for something else?