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Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Additionally we are shipping Kinesin Family Member 20A Kits (8) and Kinesin Family Member 20A Proteins (4) and many more products for this protein.
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Human Polyclonal KIF20A Primary Antibody for ELISA, WB - ABIN1531679
Horrevoets, Fontijn, van Zonneveld, de Vries, ten Cate, Pannekoek et al.: Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel ... in Blood 1999
Show all 3 references for ABIN1531679
Human Polyclonal KIF20A Primary Antibody for IF, IHC - ABIN1532703
Lai, Fernald, Zhao, Le Beau: cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin-like gene. in Gene 2000
Show all 2 references for ABIN1532703
Chicken Polyclonal KIF20A Primary Antibody for IHC, WB - ABIN2792240
Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006
Human Polyclonal KIF20A Primary Antibody for WB - ABIN523488
Lee, McCormick, Saya: Mad2 inhibits the mitotic kinesin MKlp2. in The Journal of cell biology 2010
Report expression of mt2 and smt-B upon cadmium exposure and cold shock in zebrafish (Danio rerio).
we identify KIF20A as a direct transcriptional target of FOXM1 (show FOXM1 Antibodies), involved in paclitaxel action and resistance
Our results provide insight into the link between regulation of KIF20A-mediated trafficking of IGF2BP3 (show IGF2BP3 Antibodies)-containing stress granules and modulation of the motility and invasiveness in pancreatic cancers.
Kif20a expression was upregulated in pancreatic ductal adenocarcinoma and pancreatic neuroendocrine cancer compared with normal pancreas. Kif20a silencing resulted in inhibition of proliferation, motility, and invasion of pancreatic cancer cell lines.
Authors propose that phosphoregulation of MKlp2 by Cdk1/cyclin B1 ensures that activation of MKlp2 kinesin and relocation of the CPC occur at the appropriate time and space for proper mitotic progression and genomic stability.
targeting Aurora B (show AURKB Antibodies) to the cell cortex (or the equatorial cortex) by MKlp2 is essential for the maintenance of the ingressing furrow for successful cytokinesis
Primary melanomas that were positive for KIF20A showed a significantly greater thickness than those that were negative, and patients with KIF20A+ melanoma tended to develop recurrence earlier.
Used proteomics to identify the genistein-induced protein alterations in gastric cancer cells and found the silencing of KIF20A inhibited cell viability and induced G2/M arrest,& also increased cancer cell sensitivity to genistein inhibition.
Collaboration of RAB6KIFL and disc large (show DLG4 Antibodies) homologue 5 is likely to be involved in pancreatic cancer.
Data demonstrate that Mklp2 and the chromosomal passenger complex mutually depend on each other for microtubule midzone localization, and that the association between the CPC and Mklp2 is negatively regulated by Cdk1 (show CDK1 Antibodies).
KIF20A (Rab6KIFL/MKlp2) is required for cytokinesis
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.
kinesin family member 20A
, metallothionein 2
, kinesin-like protein KIF20A-like
, RAB6 interacting, kinesin-like (rabkinesin6)
, kinesin-like protein KIF20A
, mitotic kinesin-like protein 2
, rab6-interacting kinesin-like protein
, kinesin-like protein 174