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Kruppel-Like Factor 4 (Gut) Proteins (KLF4)

a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene [RGD, Feb 2006].. Additionally we are shipping KLF4 Antibodies (231) and KLF4 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KLF4 9314 O43474
KLF4 16600 Q60793
Rat KLF4 KLF4 114505  
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Top KLF4 Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human HIS-CaM 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_HEK-293 Cells Human TAT tag   100 μg Log in to see 2 to 3 Days
$745.50
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$809.60
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_Escherichia coli (E. coli) Human HIS-CaM   10 μg Log in to see 15 to 19 Days
$314.16
Details
HOST_HEK-293 Human TAT tag   0.005 mg Log in to see 2 to 3 Days
$178.75
Details
HOST_HEK-293 Cells Human TAT tag   25 μg Log in to see 15 to 19 Days
$314.16
Details

KLF4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,
Mouse (Murine)
,

Top referenced KLF4 Proteins

  1. Human KLF4 Protein expressed in Escherichia coli (E. coli) - ABIN667940 : Geiman, Ton-That, Johnson, Yang: Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction. in Nucleic acids research 2000 (PubMed)
    Show all 2 references for ABIN667940

  2. Human KLF4 Protein expressed in Wheat germ - ABIN1308754 : Rivero, Díaz-Guerra, Monsalve, Laborda, García-Ramírez: DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis. in Journal of molecular biology 2012 (PubMed)
    Show all 2 references for ABIN1308754

More Proteins for Kruppel-Like Factor 4 (Gut) (KLF4) Interaction Partners

Zebrafish Kruppel-Like Factor 4 (Gut) (KLF4) interaction partners

  1. zebrafih Klf4a is essential for the repression of intestinal cell proliferation

  2. Proper heart valve formation in zebrafish critically depends on protein kinase D2 (show PKD2 Proteins)-histone deacetylase 5 (show HDAC5 Proteins)-Kruppel-like factor signaling.

Human Kruppel-Like Factor 4 (Gut) (KLF4) interaction partners

  1. The p53 (show TP53 Proteins)-KLF4-CEBPA (show CEBPA Proteins) axis is deregulated in AML (show RUNX1 Proteins) but can be functionally restored by conventional chemotherapy and novel p53 (show TP53 Proteins) activating treatments.

  2. Several novel and known AKT (show AKT1 Proteins) phosphorylation sites are identified within OCT4 (show POU5F1 Proteins), SOX2 (show SOX2 Proteins) and KLF4.

  3. KLF4 is probably repressed by histone acetylation in lung cancer.

  4. The dysregulated KLF4/HNF-6 (show ONECUT1 Proteins) pathway drives dedifferentition and progression of HCC (show FAM126A Proteins).

  5. Overexpression of KLF4 inhibited virus-induced activation of ISRE and IFN-b promoter in cells, while knockdown of KLF4 potentiated viral infection-triggered induction of IFNB1 (show IFNB1 Proteins) and downstream genes and attenuated viral replication.

  6. these are the first two cases reported of the simultaneous occurrence of secretory meningiomas with mutation of KLF4 in collision with a glioblastoma and an anaplastic astrocytoma, respectively

  7. KLF4-regulated drug resistance might, at least partially, positively regulate high-mobility group box 1 (HMGB1 (show HMGB1 Proteins)), which is a significant contributor to chemoresistance in osteosarcoma cells

  8. Authors demonstrate that F-box only protein 22 (FBXO22 (show FBXO22 Proteins)) interacts with and thereby destabilizes KLF4 via polyubiquitination. As a result, FBXO22 (show FBXO22 Proteins) could promote HCC (show FAM126A Proteins) cells proliferation.

  9. Angiotensin II can modulate epigenetic regulation in podocytes and renin (show REN Proteins)-angiotensin blockade inhibits these actions in part via KLF4 in proteinuric kidney diseases.

  10. Arginine methylation of KLF4 by PRMT5 (show PRMT5 Proteins) inhibits KLF4 ubiquitylation by VHL (show VHL Proteins) and thereby reduces KLF4 turnover.

Xenopus laevis Kruppel-Like Factor 4 (Gut) (KLF4) interaction partners

  1. Klf4 is transcribed both maternally and zygotically and the transcript is ubiquitous in embryos during germ-layer formation

Mouse (Murine) Kruppel-Like Factor 4 (Gut) (KLF4) interaction partners

  1. Results suggest that Kruppel-like factor 4 is not required for retinal cell differentiation or survival. Data support a hypothesis that KLF4 suppresses axon growth during development.

  2. KLF4 is a master regulator of EndMT in CCM pathology; thus, the inhibition of Klf4 expression may have a therapeutic role in limiting CCM appearance and progression.

  3. Authors show that absence of Klf4 accelerates carcinogenesis and correlates with the absence of cytokeratin 1 (show KRT1 Proteins) expression. Results suggest a potential role for KLF4 as a tumor suppressor gene for the tongue epithelium.

  4. KLF-4 was downregulated in the TGF-beta (show TGFB1 Proteins)-induced EMT (show ITK Proteins) model in LA-4 cells. KLF-4 overexpression markedly reduced the PAI-1 (show SERPINE1 Proteins) expression and inhibited the TGF-beta (show TGFB1 Proteins)-induced EMT (show ITK Proteins) .

  5. Data show that CCAAT-enhancer-binding protein-alpha (C/EBPalpha (show CEBPA Proteins)) directly regulates Kruppel-like factor 4 (Klf4) expression and increasing the levels of histone demethylase Lsd1 (show KDM1A Proteins) and transcription factor Brd4 (show BRD4 Proteins) in B cell.

  6. Angiotensin II can modulate epigenetic regulation in podocytes and renin (show REN Proteins)-angiotensin blockade inhibits these actions in part via KLF4 in proteinuric kidney diseases.

  7. Data indicate that miR (show MLXIP Proteins)-25 is a novel negative regulator of adipocyte differentiation and it suppressed 3T3-L1 adipogenesis by targeting KLF4 and C/EBPalpha (show CEBPA Proteins), which provides novel insights into the molecular mechanism of miRNA-mediated cellular differentiation.

  8. transcriptional cooperation between GR and Klf4 may determine cell-type specific gene expression regulation

  9. unravels a novel mechanism how matrix stiffness regulates cellular proliferation and highlights the importance of matrix stiffness-modulated Klf5 (show KLF5 Proteins)/Klf4 in the regulation of renal physiologic functions and fibrosis progression

  10. endothelial-specific loss of Mekk3 (show MAP3K3 Proteins), Klf2 (show KLF2 Proteins) or Klf4 markedly prevents cerebral cavernous malformation lesion formation, reverses the increase in Rho activity, and rescues lethality

Pig (Porcine) Kruppel-Like Factor 4 (Gut) (KLF4) interaction partners

  1. miR (show MYLIP Proteins)-92a coregulates KLF4 and KLF2 (show KLF2 Proteins) expression in arterial endothelium and contributes to phenotype heterogeneity associated with regional atherosusceptibility and protection in vivo.

KLF4 Protein Profile

Protein Summary

a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene

Gene names and symbols associated with KLF4

  • Kruppel-like factor 4 (gut) (KLF4)
  • Kruppel-like factor 4a (klf4a)
  • Kruppel-like factor 4 (klf4)
  • Kruppel-like factor 4 (gut) (klf4)
  • Kruppel-like factor 4 (gut) (Klf4)
  • biklf protein
  • biklf-A protein
  • EZF protein
  • Gklf protein
  • KLF4 protein
  • Zie protein

Protein level used designations for KLF4

Krueppel-like factor 4 , Kruppel-like transcription factor 4a , Kruppel-like factor 4 (gut) , Kruppel-like factor 4 , endothelial Kruppel-like zinc finger protein , epithelial zinc finger protein EZF , gut-enriched krueppel-like factor , Kruppel-like transcription factor , blood island enriched kruppel like factor , Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF)

GENE ID SPECIES
100302636 Ovis aries
100054047 Equus caballus
562155 Danio rerio
711169 Macaca mulatta
100217346 Salmo salar
100379626 Felis catus
9314 Homo sapiens
379518 Xenopus laevis
770254 Gallus gallus
16600 Mus musculus
114505 Rattus norvegicus
520842 Bos taurus
595111 Sus scrofa
100735339 Cavia porcellus
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