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a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene [RGD, Feb 2006].. Additionally we are shipping KLF4 Antibodies (260) and KLF4 Kits (5) and many more products for this protein.
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Human KLF4 Protein expressed in Escherichia coli (E. coli) - ABIN667940
Geiman, Ton-That, Johnson, Yang: Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction. in Nucleic acids research 2000
Show all 2 references for ABIN667940
Human KLF4 Protein expressed in Wheat germ - ABIN1308754
Rivero, Díaz-Guerra, Monsalve, Laborda, García-Ramírez: DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis. in Journal of molecular biology 2012
Show all 2 references for ABIN1308754
zebrafih Klf4a is essential for the repression of intestinal cell proliferation
Proper heart valve formation in zebrafish critically depends on protein kinase D2 (show PKD2 Proteins)-histone deacetylase 5 (show HDAC5 Proteins)-Kruppel-like factor signaling.
The p53 (show TP53 Proteins)-KLF4-CEBPA (show CEBPA Proteins) axis is deregulated in AML (show RUNX1 Proteins) but can be functionally restored by conventional chemotherapy and novel p53 (show TP53 Proteins) activating treatments.
Several novel and known AKT (show AKT1 Proteins) phosphorylation sites are identified within OCT4 (show POU5F1 Proteins), SOX2 (show SOX2 Proteins) and KLF4.
KLF4 is probably repressed by histone acetylation in lung cancer.
The dysregulated KLF4/HNF-6 (show ONECUT1 Proteins) pathway drives dedifferentition and progression of HCC (show FAM126A Proteins).
Overexpression of KLF4 inhibited virus-induced activation of ISRE and IFN-b promoter in cells, while knockdown of KLF4 potentiated viral infection-triggered induction of IFNB1 (show IFNB1 Proteins) and downstream genes and attenuated viral replication.
these are the first two cases reported of the simultaneous occurrence of secretory meningiomas with mutation of KLF4 in collision with a glioblastoma and an anaplastic astrocytoma, respectively
KLF4-regulated drug resistance might, at least partially, positively regulate high-mobility group box 1 (HMGB1 (show HMGB1 Proteins)), which is a significant contributor to chemoresistance in osteosarcoma cells
Authors demonstrate that F-box only protein 22 (FBXO22 (show FBXO22 Proteins)) interacts with and thereby destabilizes KLF4 via polyubiquitination. As a result, FBXO22 (show FBXO22 Proteins) could promote HCC (show FAM126A Proteins) cells proliferation.
Angiotensin II can modulate epigenetic regulation in podocytes and renin (show REN Proteins)-angiotensin blockade inhibits these actions in part via KLF4 in proteinuric kidney diseases.
Arginine methylation of KLF4 by PRMT5 (show PRMT5 Proteins) inhibits KLF4 ubiquitylation by VHL (show VHL Proteins) and thereby reduces KLF4 turnover.
Klf4 is transcribed both maternally and zygotically and the transcript is ubiquitous in embryos during germ-layer formation
Results suggest that Kruppel-like factor 4 is not required for retinal cell differentiation or survival. Data support a hypothesis that KLF4 suppresses axon growth during development.
KLF4 is a master regulator of EndMT in CCM pathology; thus, the inhibition of Klf4 expression may have a therapeutic role in limiting CCM appearance and progression.
Authors show that absence of Klf4 accelerates carcinogenesis and correlates with the absence of cytokeratin 1 (show KRT1 Proteins) expression. Results suggest a potential role for KLF4 as a tumor suppressor gene for the tongue epithelium.
KLF-4 was downregulated in the TGF-beta (show TGFB1 Proteins)-induced EMT (show ITK Proteins) model in LA-4 cells. KLF-4 overexpression markedly reduced the PAI-1 (show SERPINE1 Proteins) expression and inhibited the TGF-beta (show TGFB1 Proteins)-induced EMT (show ITK Proteins) .
Data show that CCAAT-enhancer-binding protein-alpha (C/EBPalpha (show CEBPA Proteins)) directly regulates Kruppel-like factor 4 (Klf4) expression and increasing the levels of histone demethylase Lsd1 (show KDM1A Proteins) and transcription factor Brd4 (show BRD4 Proteins) in B cell.
Data indicate that miR (show MLXIP Proteins)-25 is a novel negative regulator of adipocyte differentiation and it suppressed 3T3-L1 adipogenesis by targeting KLF4 and C/EBPalpha (show CEBPA Proteins), which provides novel insights into the molecular mechanism of miRNA-mediated cellular differentiation.
transcriptional cooperation between GR and Klf4 may determine cell-type specific gene expression regulation
unravels a novel mechanism how matrix stiffness regulates cellular proliferation and highlights the importance of matrix stiffness-modulated Klf5 (show KLF5 Proteins)/Klf4 in the regulation of renal physiologic functions and fibrosis progression
endothelial-specific loss of Mekk3 (show MAP3K3 Proteins), Klf2 (show KLF2 Proteins) or Klf4 markedly prevents cerebral cavernous malformation lesion formation, reverses the increase in Rho activity, and rescues lethality
miR (show MYLIP Proteins)-92a coregulates KLF4 and KLF2 (show KLF2 Proteins) expression in arterial endothelium and contributes to phenotype heterogeneity associated with regional atherosusceptibility and protection in vivo.
a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene
Krueppel-like factor 4
, Kruppel-like transcription factor 4a
, Kruppel-like factor 4 (gut)
, Kruppel-like factor 4
, endothelial Kruppel-like zinc finger protein
, epithelial zinc finger protein EZF
, gut-enriched krueppel-like factor
, Kruppel-like transcription factor
, blood island enriched kruppel like factor
, Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF)