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Kruppel-Like Factor 4 (Gut) Proteins (KLF4)

a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene [RGD, Feb 2006].. Additionally we are shipping KLF4 Antibodies (267) and KLF4 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KLF4 9314 O43474
KLF4 16600 Q60793
Rat KLF4 KLF4 114505  
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Top KLF4 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human HIS-CaM 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_HEK-293 Cells Human TAT tag   100 μg Log in to see 2 to 3 Days
$745.50
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$809.60
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_HEK-293 Human TAT tag   0.005 mg Log in to see 2 to 3 Days
$178.75
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$467.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

KLF4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,
Mouse (Murine)
,

Top referenced KLF4 Proteins

  1. Human KLF4 Protein expressed in Escherichia coli (E. coli) - ABIN667940 : Geiman, Ton-That, Johnson, Yang: Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction. in Nucleic acids research 2000 (PubMed)
    Show all 2 references for ABIN667940

  2. Human KLF4 Protein expressed in Human - ABIN2724292 : Boxer, Barajas, Tao, Zhang, Khavari: ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. in Genes & development 2014 (PubMed)
    Show all 2 references for ABIN2724292

  3. Human KLF4 Protein expressed in Wheat germ - ABIN1308754 : Rivero, Díaz-Guerra, Monsalve, Laborda, García-Ramírez: DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis. in Journal of molecular biology 2012 (PubMed)
    Show all 2 references for ABIN1308754

More Proteins for Kruppel-Like Factor 4 (Gut) (KLF4) Interaction Partners

Zebrafish Kruppel-Like Factor 4 (Gut) (KLF4) interaction partners

  1. zebrafih Klf4a is essential for the repression of intestinal cell proliferation

  2. Proper heart valve formation in zebrafish critically depends on protein kinase D2 (show PKD2 Proteins)-histone deacetylase 5 (show HDAC5 Proteins)-Kruppel-like factor signaling.

Human Kruppel-Like Factor 4 (Gut) (KLF4) interaction partners

  1. Findings suggest that, in obese status, the lower expression level of A2bAR, KLF4, and KLF15 of visceral adipose tissue may correlate with obese-dyslipidemia induced inflammation in Uygur population.

  2. Data demonstrated that miR (show MLXIP Proteins)-92a may play a positive role in the colorectal carcinogenesis by promoting the proliferation and migration of CRC (show CALR Proteins) cells through targeting KLF4 as well as downstream p21 (show CDKN1A Proteins).

  3. Study demonstrates that KLF4 plays a significant role in the pathogenesis of colorectal neoplasia.

  4. we show that the two PAX6 (show PAX6 Proteins) isoforms differentially and cooperatively regulate the expression of genes specific to the structure and functions of the corneal epithelium, particularly keratin 3 (KRT3) and keratin 12 (KRT12 (show KRT12 Proteins)). PAX6 (show PAX6 Proteins) isoform-a induced KRT3 expression by targeting its upstream region. KLF4 enhanced this induction. A combination of PAX6 (show PAX6 Proteins) isoform-b, KLF4, and OCT4 (show POU5F1 Proteins) induced KRT12 (show KRT12 Proteins) expression

  5. we sequenced KLF4 in approximately 1000 NSCL (show NHLH1 Proteins)/P cases and 300 controls. By one statistical test, missense variants of KLF4 as a group were enriched in cases versus controls. Moreover, two patient-derived KLF4 variants disrupted periderm differentiation upon forced expression in zebrafish embryos, suggesting that they have dominant-negative effect.

  6. A novel method using an inactivated viral particle to package and deliver four purified recombinant Yamanaka transcription factors (Sox2 (show SOX2 Proteins), Oct4 (show POU5F1 Proteins), Klf4, and c-Myc (show MYC Proteins)) resulting in reprogramming of human primary fibroblasts has been described.

  7. CXCR4 (show CXCR4 Proteins) was co-expressed with all investigated neural and embryonic stem cell markers in both primary and recurrent tissues, whereas CXCR7 was mostly found on stem cell marker-negative cells, but was co-expressed with KLF-4 on a distinct GBM cell subpopulation

  8. findings suggest that KLF4 may represent a potential biomarker for EC dysfunction

  9. KLF4 might play Janus-faced roles in oral squamous cell carcinoma, acting both as a tumor suppressor and as an oncogene (show RAB1A Proteins).

  10. The p53 (show TP53 Proteins)-KLF4-CEBPA (show CEBPA Proteins) axis is deregulated in AML (show RUNX1 Proteins) but can be functionally restored by conventional chemotherapy and novel p53 (show TP53 Proteins) activating treatments.

Xenopus laevis Kruppel-Like Factor 4 (Gut) (KLF4) interaction partners

  1. Klf4 is transcribed both maternally and zygotically and the transcript is ubiquitous in embryos during germ-layer formation

Mouse (Murine) Kruppel-Like Factor 4 (Gut) (KLF4) interaction partners

  1. Data show that the reprogramming factors OCT4 (show POU5F1 Proteins), SOX2 (show SOX2 Proteins), KLF4, and MYC (show MYC Proteins) (OSKM) drive cells along two distinct and parallel pathways, one pluripotent and one endodermal.

  2. Study demonstrates that KLF4 plays a significant role in the pathogenesis of colorectal neoplasia.

  3. our study provides valuable information on the molecular interactions between OSKM(Oct4 (show POU5F1 Proteins), Sox2 (show SOX2 Proteins), Klf4, and Myc (show MYC Proteins)) and cofactors and molecular mechanisms for the functional importance of Set1a in ESCs (show NR2E3 Proteins) and early development

  4. Data show that R-Smad Proteins SMAD1 and SMAD5, which transduce bone morphogenetic protein (BMP) signals, recognize enhancer regions together with Kruppel-like factors KLF4 and KLF5 in naive embryonic stem cell (mESCs).

  5. Results suggest that Kruppel-like factor 4 is not required for retinal cell differentiation or survival. Data support a hypothesis that KLF4 suppresses axon growth during development.

  6. KLF4 is a master regulator of EndMT in CCM pathology; thus, the inhibition of Klf4 expression may have a therapeutic role in limiting CCM appearance and progression.

  7. Authors show that absence of Klf4 accelerates carcinogenesis and correlates with the absence of cytokeratin 1 (show KRT1 Proteins) expression. Results suggest a potential role for KLF4 as a tumor suppressor gene for the tongue epithelium.

  8. KLF-4 was downregulated in the TGF-beta (show TGFB1 Proteins)-induced EMT (show ITK Proteins) model in LA-4 cells. KLF-4 overexpression markedly reduced the PAI-1 (show SERPINE1 Proteins) expression and inhibited the TGF-beta (show TGFB1 Proteins)-induced EMT (show ITK Proteins) .

  9. Data show that CCAAT-enhancer-binding protein-alpha (C/EBPalpha (show CEBPA Proteins)) directly regulates Kruppel-like factor 4 (Klf4) expression and increasing the levels of histone demethylase Lsd1 (show KDM1A Proteins) and transcription factor Brd4 (show BRD4 Proteins) in B cell.

  10. Angiotensin II can modulate epigenetic regulation in podocytes and renin (show REN Proteins)-angiotensin blockade inhibits these actions in part via KLF4 in proteinuric kidney diseases.

Pig (Porcine) Kruppel-Like Factor 4 (Gut) (KLF4) interaction partners

  1. miR (show MYLIP Proteins)-92a coregulates KLF4 and KLF2 (show KLF2 Proteins) expression in arterial endothelium and contributes to phenotype heterogeneity associated with regional atherosusceptibility and protection in vivo.

KLF4 Protein Profile

Protein Summary

a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene

Gene names and symbols associated with KLF4

  • Kruppel-like factor 4 (gut) (KLF4)
  • Kruppel-like factor 4a (klf4a)
  • Kruppel-like factor 4 (klf4)
  • Kruppel-like factor 4 (gut) (klf4)
  • Kruppel-like factor 4 (gut) (Klf4)
  • biklf protein
  • biklf-A protein
  • EZF protein
  • Gklf protein
  • KLF4 protein
  • Zie protein

Protein level used designations for KLF4

Krueppel-like factor 4 , Kruppel-like transcription factor 4a , Kruppel-like factor 4 (gut) , Kruppel-like factor 4 , endothelial Kruppel-like zinc finger protein , epithelial zinc finger protein EZF , gut-enriched krueppel-like factor , Kruppel-like transcription factor , blood island enriched kruppel like factor , Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF)

GENE ID SPECIES
100302636 Ovis aries
100054047 Equus caballus
562155 Danio rerio
711169 Macaca mulatta
100217346 Salmo salar
100379626 Felis catus
9314 Homo sapiens
379518 Xenopus laevis
770254 Gallus gallus
16600 Mus musculus
114505 Rattus norvegicus
520842 Bos taurus
595111 Sus scrofa
100735339 Cavia porcellus
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