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KCNIP3 encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Additionally we are shipping Kv Channel Interacting Protein 3, Calsenilin Proteins (13) and Kv Channel Interacting Protein 3, Calsenilin Kits (10) and many more products for this protein.
Showing 10 out of 146 products:
Mammalian Monoclonal KCNIP3 Primary Antibody for ISt, IHC - ABIN1304731
Menegola, Trimmer: Unanticipated region- and cell-specific downregulation of individual KChIP auxiliary subunit isotypes in Kv4.2 knock-out mouse brain. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Show all 16 Pubmed References
Cow (Bovine) Polyclonal KCNIP3 Primary Antibody for IHC, WB - ABIN2777506
Zaidi, Thomson, Choi, Buxbaum, Wasco: Intracellular calcium modulates the nuclear translocation of calsenilin. in Journal of neurochemistry 2004
Show all 2 Pubmed References
Human Polyclonal KCNIP3 Primary Antibody for ELISA, WB - ABIN4287519
Rivas, Mellström, Torres, Cali, Ferrara, Terracciano, Zannini, Morreale de Escobar, Naranjo: The DREAM protein is associated with thyroid enlargement and nodular development. in Molecular endocrinology (Baltimore, Md.) 2009
targeting SmgGDS (show RAP1GDS1 Antibodies) induces nucleolar stress, resulting in profound loss of DREAM target gene expression required for G1, S and G2 progression, and ultimately resulting in cell cycle arrest.
Disruption of DREAM and RB-E2F (show E2F1 Antibodies) complexes by oncoproteins from DNA tumor viruses leads to upregulation of cell cycle genes and impairs growth-inhibiting pathways, including the p53 (show TP53 Antibodies)-mediated downregulation of cell cycle genes. [review]
This study shows the application of hydrogen-deuterium exchange mass spectrometry and site-directed mutagenesis to investigate the Ca(2 (show CA2 Antibodies)+) binding properties and the subsequent conformational changes of full-length DREAM. EF-hands undergo large conformation changes upon calcium binding even though the EF-1 (show EEF1D Antibodies) hand is not capable of binding to Ca(2 (show CA2 Antibodies)+).
Our approach yields high confidence ranked target gene maps for TP53 (show TP53 Antibodies), DREAM, MMB-FOXM1 (show FOXM1 Antibodies) and RB-E2F (show E2F1 Antibodies) and enables prediction and distinction of CC regulation. A web-based atlas at www.targetgenereg.org enables assessing the regulation of any human gene of interest.
downregulation of these genes through the p53 (show TP53 Antibodies)-p21 (show CDKN1A Antibodies)-DREAM-CDE/CHR pathway appears to be a principal mechanism for G2/M cell cycle arrest by p53 (show TP53 Antibodies).
Our results support the hypothesis that KChIPs enhances Kv4.2 (show KCND2 Antibodies) functional expression by a 1 : 1 suppression of the N-terminal FERN domain and by producing additional positive regulatory effects on functional channel expression.
GCM1 (show GCM1 Antibodies)-directed villous trophoblast differentiation is repressed by DREAM
p53 (show TP53 Antibodies) can repress transcription of cell cycle genes through a p21(WAF1/CIP1 (show CDKN1A Antibodies))-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements.
The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function.
expression of calsenilin leads to a disruption of presenilin 1 (show PSEN1 Antibodies)/gamma-secretase-mediated epsilon-cleavage of N-cadherin (show CDH2 Antibodies), which results in the significant accumulation of N-cadherin (show CDH2 Antibodies) C-terminal fragment 1
Genome-wide analysis of trigeminal neurons in daDREAM transgenic mice identified cathepsin L (show CTSL1 Antibodies) and the monoglyceride lipase (show MGLL Antibodies) as two new DREAM transcriptional targets related to pain.
association of PS1 (show PSEN1 Antibodies) carboxyl peptide (residues 445-467, HL9 (show DDC Antibodies)) with DREAM is calcium dependent and stabilized by a cluster of three aromatic residues: F462 and F465 from PS1 (show PSEN1 Antibodies) and F252 from DREAM.
The association of calcium-bound calmodulin (CaM) with DREAM is mediated by a short amphipathic amino acid sequence located between residues 29 and 44 on DREAM.
The protein DREAM decreases development of L-DOPA-induced dyskinesia in mice and reduces L-DOPA-induced expression of FosB (show FOSB Antibodies), phosphoacetylated histone H3 (show HIST3H3 Antibodies), and dynorphin-B in the striatum
NS5806 directly interacts with KChIP3 and modulates the interactions between this calcium-binding protein (show GUCA1B Antibodies) and the T1 domain of the Kv4.3 (show KCND3 Antibodies) channels through reorientation of helix 10 on KChIP3
studies define the critical opposing functions of DREAM and USF1 (show USF1 Antibodies) in inhibiting and inducing A20 (show TNFAIP3 Antibodies) expression
Expression of DREAM in neuroblastoma (show ARHGEF16 Antibodies) cells enhances cisplatin mediated caspase-3 (show CASP3 Antibodies) activity.
Restoring CANT1 (show CANT1 Antibodies) levels in neuroblastoma (show ARHGEF16 Antibodies) clones recovered the phenotype, thus confirming a key role of CANT1 (show CANT1 Antibodies), and of the regulation of its gene by DREAM, in the control of protein synthesis and degradation
In cardiomyocytes, [Ca2 (show CA2 Antibodies)+]i-activated calmodulin kinase II (CaMKII (show CAMK2 Antibodies)) activates downstreamregulatory element (DRE (show SUFUH Antibodies)) binding transcription factor DREAM, which consequently suppresses the expression of L-type calcium channel 1C-subunit gene (Cacna1c (show CACNA1C Antibodies)).
zebrafish calsenilin is involved in endocrine cell differentiation and morphogenesis within the pancreas
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.
A-type potassium channel modulatory protein 3
, DRE-antagonist modulator
, calsenilin, presenilin-binding protein, EF hand transcription factor
, kv channel-interacting protein 3
, potassium channel interacting protein 3
, calsenilin, presenilin binding protein, EF hand transcription factor
, A-type potassium channel modulating protein 3
, calsenilin presenilin-binding protein EF hand transcription factor
, calsenilin, presenilin-binding protein, EF hand transcription fa
, downstream regulatory element-antagonist modulator
, Kv channel interacting protein 3, calsenilin