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May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. Additionally we are shipping LAG1 Homolog, Ceramide Synthase 5 Proteins (3) and many more products for this protein.
Showing 10 out of 68 products:
Human Polyclonal LASS5 Primary Antibody for WB - ABIN223496
Yamane, Miyazawa, Moriya, Abe, Yamane et al.: D,L-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (DL-PDMP) increases endoplasmic reticulum stress, autophagy and apoptosis accompanying ceramide accumulation via ceramide synthase 5 protein ... in Biochimie 2011
Cow (Bovine) Polyclonal LASS5 Primary Antibody for ELISA - ABIN314243
Min, Mesika, Sivaguru, Van Veldhoven, Alexander, Futerman, Alexander: (Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1. in Molecular cancer research : MCR 2007
LASS5 interacts with SDHB (show SDHB Antibodies) and synergistically represses p53 (show TP53 Antibodies) and p21 (show CDKN1A Antibodies) activity.
Studied the role of ceramide synthase 5 (LASS5 or CERS5) gene in atherosclerosis. Downregulation of LASS5 by siRNA was found to attenuate ceramide production and increase expression of some AMPK (show PRKAA1 Antibodies) target genes in HUVEC. Found that LASS5 was involved in negative regulation of atherosclerosis-related genes, such as AMPK (show PRKAA1 Antibodies)-alpha.
mRNA level of CerS5 is higher in cancerous cell lines and decreases following the induction of apoptosis.
Overexpression of CerS5 increased apoptosis in HeLa cells.
study identifies LASS5 as a genuine dihydroceramide synthase and demonstrates that mammalian dihydroceramide synthases do not require additional subunits for their activity
accumulation of C(16)-ceramide in mitochondria formed from the protein kinase C (show PKC Antibodies)-dependent salvage pathway results at least in part from the action of longevity-assurance homologue 5, and the generated ceramide modulates the p38 (show CRK Antibodies) cascade via PP1 (show PPA1 Antibodies)
Down-regulation of either acid sphingomyelinase (show SMPD1 Antibodies) or LASS 5-attenuated ceramide accumulation and H/R-induced Bax (show BAX Antibodies) translocation to mitochondria.
Ceramide synthase 5 is essential to maintain C16:0-ceramide pools and contributes to the development of diet-induced obesity.
Transfection of Lass5 cDNA into or pulse of Lass5 peptide onto B7-1 (show CD80 Antibodies) positive RMA-S cells overcomes the requirement of the B7-1 (show CD80 Antibodies)/CD28 (show CD28 Antibodies) signal for T effector response.
Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1 (show CERS1 Antibodies)-Cers6 (show CERS6 Antibodies)) activity in macrophages is responsible for the accumulation of ceramide.
Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes.
Lag1p family members trh1 (show CERS4 Antibodies) and trh4 regulate (dihydro)ceramide synthases responsible for production of sphingolipids containing different fatty acids
LASS5 is the major ceramide synthase gene product involved in sphingolipid production that may also regulate phosphatidylcholine (show SGMS2 Antibodies) metabolism in pulmonary epithelia
May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl- (C16) ceramide) in a fumonisin B1-independent manner (By similarity).
LAG1 homolog, ceramide synthase 5
, LAG1 longevity assurance homolog 5-like
, LAG1 longevity assurance homolog 5
, TRAM homolog 4
, longevity assurance homolog 5
, translocating chain-associating membrane protein homolog 4