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LIM Homeobox Transcription Factor 1, beta Proteins (LMX1B)

LMX1B encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. Additionally we are shipping LIM Homeobox Transcription Factor 1, beta Antibodies (80) and LIM Homeobox Transcription Factor 1, beta Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LMX1B 16917 O88609
Rat LMX1B LMX1B 114501  
LMX1B 4010 O60663
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Top LIM Homeobox Transcription Factor 1, beta Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,107.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
Details

LMX1B Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for LIM Homeobox Transcription Factor 1, beta (LMX1B) Interaction Partners

Mouse (Murine) LIM Homeobox Transcription Factor 1, beta (LMX1B) interaction partners

  1. Otx2 (show OTX2 Proteins) critically depends on Lmx1b for the formation of mdDA neurons.

  2. results demonstrate an important role for the intersection of Lmx1b and Hoxb8 (show HOXB8 Proteins)::cre expression in the development of nociceptive dorsal horn circuits critical for mechanical and thermal pain processing.

  3. Co-immunoprecipitation experiments show that both wild-type and Icst LMX1B are found in complexes with LIM domain binding protein 1 (LDB1 (show LDB1 Proteins)), resulting in lower levels of functional LMX1B in Icst heterozygotes than null heterozygotes

  4. We posit that microRNA modulation of the Lmx1b/Wnt (show WNT2 Proteins) axis in the early midbrain/isthmus could determine midbrain size and allocation of dopamine progenitors.

  5. Cell biological and biophysical experiments with primary podocytes isolated after 1 week of Lmx1b inactivation indicated dysregulation of actin cytoskeleton organization

  6. Lmx1b, a key transcription factor for the specification of 5-HT (show DDC Proteins) and dopaminergic transmitter phenotypes during embryogenesis, determines some peptide phenotypes in these neurons as well.

  7. Data indicate that tryptophan hydroxylase 2 Tph2 (show TPH2 Proteins)-/- and LIM homeobox transcription factor 1 beta Lmx1b-/- females displayed a change in sexual preference.

  8. A protein complex was identified containing PSPC1 (show PSPC1 Proteins), PSF (show Il3 Proteins) and LMX1B, suggesting the existence of this complex in mesodiencephalic dopaminergic neurons.

  9. Lmx1b genes are associated with skeletal development.

  10. This study demonistrated that Lmx1b promotes a neuronal glutamate (show GRIN1 Proteins) phenotype and suppresses a GABA one in the embryonic trigeminal brainstem complex

Human LIM Homeobox Transcription Factor 1, beta (LMX1B) interaction partners

  1. 38 different LMX1B polymorphisms have been found in 55 families with Nail (show CD244 Proteins)-Patella Syndrome raising the hypothesis of a genetic heterogeneity.

  2. Lmx1a (show LMX1A Proteins) and Lmx1b expression persists in mature dopaminergic neurons of the substantia nigra pars (show EPRS Proteins) compacta and the ventral tegmental area. [Review]

  3. these results reveal a sustained and essential requirement of Lmx1b for the function of midbrain dopamine neurons

  4. A heterozygous microdeletion of the entire LMX1B gene using multiplex ligation-dependent probe amplification (MLPA) in a Chinese family with nail (show CD244 Proteins) patella syndrome, is reported.

  5. Results demonstrate that loss of function may not be the only way that mutated LMX1b causes haploinsufficiency. Mutated LMX1b may interfere withdownsteam transcription events.

  6. In a large family with the two disorders with two novel frameshift TSC1 (show TSC1 Proteins) and LMX1B mutations, we describe the phenotypes

  7. LMX1B is a novel oncogene (show RAB1A Proteins) in ovarian cancer pathogenesis.

  8. this study identified two novel mutations of the LMX1B gene in three unrelated families with autosomaldominant Focal Segmental Glomerulosclerosis and no extrarenal features.

  9. LMX1B is important in regulating type IV collagen (show COL4 Proteins) gene expression in the GBM of the developing kidney and also has a likely role in regulating additional genes important in podocyte function and maintenance

  10. Data report on the association of LMX1B with autism, though it should be viewed with some caution considering the modest associations we report.

Zebrafish LIM Homeobox Transcription Factor 1, beta (LMX1B) interaction partners

  1. Lmx1b and FoxC have roles in regulating podocin expression in podocytes

  2. lmx1b paralogues may contribute to the generation of diencephalic dopaminergic precursors

  3. Results suggest that zebrafish lmx1b.1 and lmx1b.2 promote the survival of periocular mesenchymal cells that influence multiple signaling events required for proper ocular development.

  4. Imx1b.1 regulation of wnt (show WNT2 Proteins) proteins, pax8 (show PAX8 Proteins) and fibroblast growth factor 8 (fgf8 (show FGF8 Proteins)) maintains cell survival in the isthmocerebellar region

Xenopus laevis LIM Homeobox Transcription Factor 1, beta (LMX1B) interaction partners

  1. The spontaneous calcium spike activity in the hindbrain of developing Xenopus laevis larvae modulates the specification of serotonergic neurons via regulation of expression of the Lmx1b transcription factor.

  2. We have over-expressed lmx1b mRNA alone or in combination with potential interacting molecules and analysed the effects on embryonic kidney structures.

LIM Homeobox Transcription Factor 1, beta (LMX1B) Protein Profile

Protein Summary

This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with LMX1B

  • LIM homeobox transcription factor 1, beta (LMX1B)
  • LIM homeobox transcription factor 1 beta (Lmx1b)
  • LIM homeobox transcription factor 1, beta b (lmx1bb)
  • LIM homeobox transcription factor 1, beta, gene 1 (lmx1b.1)
  • LMX protein
  • LMX1 protein
  • LMX1.1 protein
  • LMX1.2 protein
  • lmx1b protein
  • lmx1b.1 protein
  • NPS1 protein
  • Xlmx1b protein

Protein level used designations for LMX1B

LIM homeobox transcription factor 1, beta , LIM homeo box transcription factor 1B , LIM homeobox transcription factor 1-beta , LIM/homeobox protein 1.2 , LIM/homeobox protein LMX1B , LMX-1.2 , LIM homeobox protein , LIM/homeobox protein 1 , LIM/homeobox protein LMX-1.2 , homeobox protein LMX-1 , homeodomain protein (lmx) , LIM homeobox transcription factor 1, beta 1 , alo , LIM homeobox protein 1b , LIM homeobox transcription factor 1-beta.1

GENE ID SPECIES
100604654 Nomascus leucogenys
16917 Mus musculus
114501 Rattus norvegicus
396312 Gallus gallus
4010 Homo sapiens
403499 Canis lupus familiaris
554360 Danio rerio
399182 Xenopus laevis
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