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Negatively regulates growth hormone (GH) receptor cell surface expression in liver. Additionally we are shipping LEPROTL1 Antibodies (3) and many more products for this protein.
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the increased expression of FGF21 (show FGF21 Proteins) during chronic undernutrition inhibits GH action on chondrocytes by activating LEPROT (show LEPR Proteins) and LEPROTL1.
both LEPROT and LEPROTL1 expression were regul (show LEPR Proteins)ated in liver by physiologic and pathologic changes in glucose homeo (show IGF1 Proteins)stasis
Transgenic mice expressing either human LEPROT or human LEPROTL1 displayed growth retardation, reduced plasma IGF1 (show IGF1 Proteins) levels, and impaired hepatic sensitivity to GH, as measured by STAT5 (show STAT5A Proteins) phosphorylation and Socs2 (show SOCS2 Proteins) mRNA expression.
Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.
leptin receptor overlapping transcript-like 1
, Leptin receptor overlapping transcript-like 1