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The protein encoded by LDOC1 contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. Additionally we are shipping LDOC1 Antibodies (41) and many more products for this protein.
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Cigarette smoke-induced promoter methylation may contribute to LDOC1 downregulation, thereby conferring oncogenic features to oral cells.
LDOC1 inhibits proliferation and promotes apoptosis by repressing NF-kappaB (show NFKB1 Proteins) activation in papillary thyroid carcinoma
Silencing of LDOC1 is a frequent event in cervical cancer and may be of interest as a molecular marker in cervical cancer.
Silencing of BEX1 (show BEX1 Proteins) and LDOC1 by promoter hypermethylation might represent a critical event in the molecular pathogenesis of oral squamous cell carcinoma (OSCC) and the male predominance of OSCC occurrence.
Letter/Case Report: LDOC1/PARP1 (show PARP1 Proteins) are down-regulated in melanoma with repeated in-transit metastases.
The aim of this study was to evaluate the possible differential expression of LDOC1 mRNA in leucocytes of peripheral blood of Down's syndrome subjects. compared with the normal population.
Over expression of LDOC1 may explain the clinical manifestation found in patients with cryptochidism and Digeorge anomaly.
LDOC1 is dramatically down-regulated in mutated chronic lymphocytic leukemia cases compared with unmutated cases, and have identified a new splice variant, LDOC1S
These observations suggest that LDOC1 is a novel regulator of NF-kappaB (show NFKB1 Proteins) that can affect the PMA or TNF-alpha (show TNF Proteins)-mediated pathway to apoptosis through inhibition of NF-kappaB (show NFKB1 Proteins) activation in BxPC3 pancreatic cancer cells.
MZF-1 (show ZFP42 Proteins) was revealed to interact with LDOC1 and enhance the activity of LDOC1 for inducing apoptosis
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.
leucine zipper, down-regulated in cancer 1
, breast cancer, up-regulated 1
, leucine zipper protein down-regulated in cancer cells
, protein LDOC1
, Protein LDOC1