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LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain.
our similar early study and recent confirming experiments using the same reagents reported by Sheng et al. failed to reproduce the phenotype of the loss of dopaminergic neurons, although the mRNA of LRRK2 was molecularly disrupted
results demonstrate that zLRRK2 is an ortholog of hLRRK2 and that the deletion of WD40 domain (show DCAF12L2 Antibodies) of zLRRK2 provides a disease model for PD
This study demostrated that G2019S LRRK2 mutation parkinson disease and REM (show REM1 Antibodies) sleep behavior disorder.
This is the first study indicating that Sp1 (show PSG1 Antibodies) signaling plays an important role in the regulation of human LRRK2 gene expression.
Induced pluripotent stem cells - derived sensory neurons with Parkinson's Disease-related LRRK2 G2019S mutation exhibited normal neurite length but had large microtubule-containing neurite aggregations.
This study demonstrated that The sleep phenotype in leucine-rich repeat kinase 2 mutations parallels that of idiopathic PD, except for absent rapid eye movement sleep behavior disorder here in the presymptomatic and symptomatic stages.
This study showed the presence of six LRRK2 p.G2019S and nine GBA (show GBA Antibodies) p.N370S mutation carriers in Parkinson disease.
The assays offer a high-throughput method of monitoring LRRK2 kinase activity.
Results indicate that non-manifesting carriers of the G2019S mutation in the leucine-rich repeat kinase 2 gene have a specific cognitive profile with executive functions
The LRRK2 p.G2019S mutation is not an important causal factor of Parkinson Disease in Colombia having similar frequencies to those reported in other Latin American populations
Fibroblasts isolated from skin biopsy specimens from patients with genetic forms of Parkinson's disease, carriers of mutations in LRRK2 and PARK2 (show PARK2 Antibodies) genes, and from a healthy volunteer were reprogrammed into induced pluripotent stem cells.
novel insights into the multiple mechanisms that dictate the association between LRRK2 and mitophagy in sporadic Parkinson's disease
14-3-3theta can regulate LRRK2 and reduce the toxicity of mutant LRRK2 through a reduction of kinase activity.
LRRK2 has a role in microglia activation and sustainment of neuroinflammation.
p21-activated kinase 6 (PAK6 (show PAK6 Antibodies)) as a novel interactor of leucine-rich repeat kinase 2 (LRRK2), a kinase involved in Parkinson's disease
The data implicate gain of LRRK2 function in the pathogenesis of Parkinson disease
LRRK2 regulates lysosome size, number and function in primary astrocytes and results show that expression of Parkinson's disease associated LRRK2 variants results in enlarged lysosomes
Present results suggest that LRRK2 may play novel roles in both the immune system and the pathogenesis of various diseases.
Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression
In the substantia nigra of LRRK2 transgenic mice, mRNA of three genes that promote cell death was upregulated, while the mRNA expression of seven genes that contribute to neurogenesis/neuroprotection was downregulated.
G2019S mutation carrying LRRK2 microglia show retarded ADP-induced motility and delayed isolation of injury. LRRK2 knockdown microglia are highly motile compared with control cells. Lrrk2 phosphorylates and inhibits focal adhesion kinase.
The Lrrk2 (-/-) mice developed lower levels of experimental autoimmune uveitis, delayed type hypersensitivity responses and cytokine production by lymphocytes than did their WT controls.
show that the LRRK2 sequence and expression patterns are conserved between pig and human
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
leucine-rich repeat serine/threonine-protein kinase 2
, leucine-rich repeat kinase 2
, leucine-rich repeat serine/threonine-protein kinase 2-like
, augmented in rheumatoid arthritis 17