anti-Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) Antibodies

Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation (By similarity).. Additionally we are shipping Lrig1 Proteins (10) and Lrig1 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Lrig1 26018 Q96JA1
Lrig1 16206 P70193
Lrig1 312574  
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Top anti-Lrig1 Antibodies at antibodies-online.com

Showing 10 out of 68 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Goat PE FACS Detection of LRIG1 in D3 Mouse Cell Line by Flow Cytometry. D3 mouse embryonic stem cell line was stained with Goat Anti-Mouse LRIG1 PE-conjugated Antigen Affinity-purified Polyclonal Antibody. Detection of LRIG1 in D3 Mouse Cell Line by Flow Cytometry. D3 mouse embryonic stem cell line was stained with Goat Anti-Mouse LRIG1 PE-conjugated Antigen Affinity-purified Polyclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$299.25
Details
Human Sheep Un-conjugated FACS, IHC Detection of LRIG1 in LNCaP Human Cell Line by Flow Cytometry. LNCaP human prostate cancer cell line was stained with Sheep Anti-Human LRIG1 Antigen Affinity-purified Polyclonal Antibody. LRIG1 in Human Kidney. LRIG1 was detected in immersion fixed paraffin-embedded sections of human kidney using Sheep Anti-Human LRIG1 Antigen Affinity-purified Polyclonal Antibody. Specific staining was localized to the cytoplasm of epithelial cells in convoluted tubules. 100 μg Log in to see 8 to 9 Days
$372.75
Details
Mouse Rabbit Un-conjugated WB LRIG1 Antibody (C-term) (ABIN1881506) western blot analysis in mouse stomach tissue lysates (35 µg/lane). This demonstrates the LRIG1 antibody detected the LRIG1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Goat Un-conjugated FACS, ICC, WB Detection of LRIG1 in bEnd.3 Mouse Cell Line by Flow Cytometry. bEnd.3 mouse endothelioma cell line was stained with Goat Anti-Mouse LRIG1 Antigen Affinity-purified Polyclonal Antibody. LRIG1 in bEnd.3 Mouse Cell Line. LRIG1 was detected in immersion fixed bEnd.3 mouse endothelioma cell line using Goat Anti-Mouse LRIG1 Antigen Affinity-purified Polyclonal Antibody. Specific staining was localized to cytoplasm. 100 μg Log in to see 8 to 9 Days
$372.75
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-LRIG1 Polyclonal Antibody, Unconjugated (ABIN735263) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Lane 1: mouse brain lysates Lane 2: mouse embryo lysates probed with Anti LRIG1 Polyclonal Antibody, Unconjugated (ABIN735263) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 120kD. Observed band size: 120kD. 100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Mouse PE FACS Detection of LRIG1 in LNCaP Human Cell Line by Flow Cytometry. LNCaP human prostate cancer cell line was stained with Mouse Anti-Human LRIG1 PE-conjugated Monoclonal Antibody. Detection of LRIG1 in LNCaP Human Cell Line by Flow Cytometry. LNCaP human prostate cancer cell line was stained with Mouse Anti-Human LRIG1 PE-conjugated Monoclonal Antibody. 25 Tests Log in to see 8 to 9 Days
$199.50
Details
Human Mouse Allophycocyanin FACS Detection of LRIG1 in LNCaP Human Cell Line by Flow Cytometry. LNCaP human prostate cancer cell line was stained with Mouse Anti-Human LRIG1 APC-conjugated Monoclonal Antibody. Detection of LRIG1 in LNCaP Human Cell Line by Flow Cytometry. LNCaP human prostate cancer cell line was stained with Mouse Anti-Human LRIG1 APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$346.50
Details
Human Mouse Un-conjugated FACS, ICC, IHC Detection of LRIG1 in LNCaP Human Cell Line by Flow Cytometry. LNCaP human prostate cancer cell line was stained with Mouse Anti-Human LRIG1 Monoclonal Antibody. LRIG1 in SK-BR-3 Human Cell Line. LRIG1 was detected in immersion fixed SK-BR-3 human breast cancer cell line using Mouse Anti-Human LRIG1 Monoclonal Antibody. Specific staining was localized to cytoplasm and cell surfaces. 100 μg Log in to see 8 to 9 Days
$267.75
Details
Human Sheep Alexa Fluor 488 FACS Detection of LRIG1 in LNCaP Hman Cell Line by Flow Cytometry. LNCaP human prostate cancer cell line was stained with Sheep Anti-Human LRIG1 Alexa Fluor 488-conjugated Antigen Affinity-purified Polyclonal Antibody. Detection of LRIG1 in LNCaP Hman Cell Line by Flow Cytometry. LNCaP human prostate cancer cell line was stained with Sheep Anti-Human LRIG1 Alexa Fluor 488-conjugated Antigen Affinity-purified Polyclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$325.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

Lrig1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Lrig1 Antibodies

  1. Mouse (Murine) Polyclonal Lrig1 Primary Antibody for FACS, ICC - ABIN4900308 : Jensen, Driskell, Watt: Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis. in Nature protocols 2010 (PubMed)
    Show all 9 references for 4900308

  2. Mouse (Murine) Polyclonal Lrig1 Primary Antibody for WB - ABIN1881506 : Ye, Gao, Xu, Zeng, Ou, Mao, Wang, He, Wang, Yang, Guo, Lei: Upregulation of LRIG1 suppresses malignant glioma cell growth by attenuating EGFR activity. in Journal of neuro-oncology 2009 (PubMed)
    Show all 2 references for 1881506

  3. Mouse (Murine) Polyclonal Lrig1 Primary Antibody for FACS - ABIN4897517 : Wong, Stange, Page, Buczacki, Wabik, Itami, van de Wetering, Poulsom, Wright, Trotter, Watt, Winton, Clevers, Jensen: Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. in Nature cell biology 2012 (PubMed)

  4. Human Polyclonal Lrig1 Primary Antibody for FACS, IHC - ABIN4900286 : Oh, Lee, Choi, Suh, Shim, Song, Kim, Lee, Oh, Jeong, Cheong, Song, Kim: USP8 modulates ubiquitination of LRIG1 for Met degradation. in Scientific reports 2014 (PubMed)

More Antibodies against Lrig1 Interaction Partners

Human Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) interaction partners

  1. LRIG1 expression may represent a barrier to EMT (show ITK Antibodies)

  2. LRIG1 role in the atrophic epidermis

  3. Downregulation of LRIG1 expression in oral verrucous carcinoma tissue is reported.

  4. LRIG1, as a negative mediated gene of tumor, can inhibit biological function of PAs (show PASK Antibodies) via inhibiting PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and Ras/Raf (show RAF1 Antibodies)/ERK (show EPHB2 Antibodies) pathways, and it might be a new target for gene therapy ofPituitary adenomas

  5. LRIG1 and Fascin-1 (show FSCN1 Antibodies) were differently expressed in cancer and normal lung tissue in patients with NSCLC, which could be a biomarker for mediastinal lymph node metastasis in NSCLC patients.

  6. Results suggest that the LRIG1could negatively control MRP-1 (show MDM4 Antibodies) and the apoptosis to improve the sensitivity of VP16-related chemotherapy.

  7. ERa-dependent expression of LRIG1 dampens ErbB3 (show ERBB3 Antibodies) signaling in luminal breast cancer cells, and by blocking ERa activity with fulvestrant, LRIG1 is decreased thus permitting ErbB3 (show ERBB3 Antibodies) accumulation, enhanced ErbB3 (show ERBB3 Antibodies) signaling to cell survival pathways

  8. These findings demonstrate that LRIG1 is an independent prognostic factor in patients with non-small cell lung cancer

  9. LRIG1 expression was associated with pathological type, differentiation status, and stage of Non-small Cell Lung Cancer. The result showed that LRIG1 was an independent prognostic factor for OS of NSCLC patients.

  10. The inhibitory effects of LRIG1 are most likely mediated by suppression of the EGFR (show EGFR Antibodies)/PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) pathway and epithelial-mesenchymal transition (EMT (show ITK Antibodies)) process.

Mouse (Murine) Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) interaction partners

  1. LRIG1 role in the atrophic epidermis

  2. LRIG1+ cells were found to re-populate the neo-epidermis on day 14, suggesting an important homeostatic role of LRIG1 in skin

  3. a subset of human duodenal tumors exhibited features of LRIG1(-/-) adenomas, including loss of LRIG1, gastric metaplasia (MUCIN5AC and MUCIN6), and increased amphiregulin (show AREG Antibodies) and Egfr (show EGFR Antibodies) activity.

  4. LRIG1 regulates the postnatal development of ICC-DMP and ICC-SMP from smooth muscle progenitors in mice.

  5. Loss of one Apc (show APC Antibodies) allele in Lrig1(+) cells results in inducible stem cell-driven model that recapitulates features of familial adenomatous polyposis.

  6. At later stages, Lrig1 expression is sustained in non-sensory tissues, whereas Lrig2 levels are enhanced in neurons and sensory epithelia.

  7. LRIG1 orchestrates corneal-tissue transparency and cell fate during repair via STAT3 (show STAT3 Antibodies).

  8. A review summarizes the data that LRIG1 is a ERBB (show EGFR Antibodies) negative regulator and tumour suppressor.

  9. LRIG1 Loss of heterozygosity (LOH) is frequent across cancers and its loss is an early event in the development of human squamous carcinomas.

  10. The Lrig1, a negative-feedback regulator of the ErbB (show EGFR Antibodies) receptor family, is highly expressed by intestinal stem cells and controls the size of the intestinal stem-cell niche by regulating the amplitude of growth-factor signalling.

Lrig1 Antigen Profile

Protein Summary

Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation (By similarity).

Gene names and symbols associated with Lrig1

  • leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) antibody
  • leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) antibody
  • D6Bwg0781e antibody
  • Img antibody
  • LIG-1 antibody
  • LIG1 antibody

Protein level used designations for Lrig1

leucine-rich repeat protein LRIG1 , leucine-rich repeats and immunoglobulin-like domains protein 1 , ortholog of mouse integral membrane glycoprotein LIG-1 , integral membrane glycoprotein

GENE ID SPECIES
26018 Homo sapiens
16206 Mus musculus
312574 Rattus norvegicus
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