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Leukocyte Cell Derived Chemotaxin 1 Proteins (LECT1)

LECT1 encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. Additionally we are shipping Leukocyte Cell Derived Chemotaxin 1 Antibodies (25) and Leukocyte Cell Derived Chemotaxin 1 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LECT1 11061 O75829
LECT1 16840 Q9Z1F6
Rat LECT1 LECT1 81512 O70367
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Top Leukocyte Cell Derived Chemotaxin 1 Proteins at antibodies-online.com

Showing 6 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$774.40
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HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
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HOST_Human Cells Human Fc Tag   100 μg Log in to see 16 Days
$327.80
Details

LECT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

More Proteins for Leukocyte Cell Derived Chemotaxin 1 (LECT1) Interaction Partners

Human Leukocyte Cell Derived Chemotaxin 1 (LECT1) interaction partners

  1. Data suggest ChM1 as potential tumor suppressor in gastric cancer and useful biomarker for the treatment and prognosis. Its expression was downregulated in cancer tissue, and correlated with advanced stages, lymph node metastasis, and poorer prognosis.

  2. intact 20-25 kDa ChM-I is stored as a component of extracellular matrix in the avascular cartilage zones, but it is inactivated by a single N-terminal proteolytic cleavage in the hypertrophic zone of growth-plate cartilage

  3. the inner meniscus contained larger amounts of ChM-I, and that the inner meniscus-derived ChM-I inhibited endothelial cell proliferation.

  4. Degenerative intervertebral disc cells express ChM-I. Administration of bFGF (show FGF2 Proteins) down-regulates the expression of ChM-I. Expression is correlated with the degree of degeneration.

  5. Inhibition of YY1 (show YY1 Proteins) in combination with forced expression of p300 (show EP300 Proteins) and Sp3 restored the expression of ChM-I in cells with a hypomethylated promoter region, but not in cells with hypermethylation.

  6. Data suggest that chondromodulin-I impairs the VEGF-A (show VEGFA Proteins)-stimulated motility of endothelial cells by destabilizing lamellipodial extensions.

  7. Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3

  8. chondromodulin-I has a pivotal role in maintaining valvular normal function by preventing angiogenesis that may lead to valvular heart diseases

  9. Cell-specific epigenetic regulation of ChM-I gene expression

  10. new hypoxia-inducible and SOX9 (show SOX9 Proteins)-regulated genes, Gdf10 (show GDF10 Proteins) and Chm-I. In addition, Mig6 (show ERRFI1 Proteins) and InhbA (show INHBA Proteins) were induced by hypoxia, predominantly via HIF-2alpha (show EPAS1 Proteins)

Mouse (Murine) Leukocyte Cell Derived Chemotaxin 1 (LECT1) interaction partners

  1. These findings indicated that Chm-I was an indispensable factor for ectopic cartilage regeneration and the maintenance of cartilage homeostasis.

  2. intact 20-25 kDa ChM-I is stored as a component of extracellular matrix in the avascular cartilage zones, but it is inactivated by a single N-terminal proteolytic cleavage in the hypertrophic zone of growth-plate cartilage

  3. the inhibitory action of ChM-I on trophoblast migration and invasion, implying the potential role of the ChM-I expression in decidual cells for the regulated tissue remodeling and angiogenesis at feto-maternal interface.

  4. chondromodulin 1 stabilizes the chondrocyte phenotype by supporting chondrogenesis but inhibiting chondrocyte hypertrophy and endochondral ossification.

  5. Role of ChM-I in cartilage and eye development

  6. chondromodulin I is a bone remodeling factor

  7. Chondromodulin I suppresses T cell responses and synovial cell proliferation, implying that this cartilage matrix protein (show MATN1 Proteins) has a therapeutic potential in rheumatoid arthritis.

  8. chondromodulin-I has a pivotal role in maintaining valvular normal function by preventing angiogenesis that may lead to valvular heart diseases

  9. The expression domains of ChM-I and TeM (show TNMD Proteins) during vertebrate development incorporate the typical avascular regions of the mesenchymal tissues.

  10. results suggest that Chm-I is involved in hypertrophic maturation of periosteal chondrocytes. Although a direct effect of Chm-I on bones is still unclear, bony callus formation was increased while external cartilaginous callus decreased in Chm1(-/-) mice

Leukocyte Cell Derived Chemotaxin 1 (LECT1) Protein Profile

Protein Summary

This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with LECT1

  • leukocyte cell derived chemotaxin 1 (lect1)
  • leukocyte cell derived chemotaxin 1 (LECT1)
  • leukocyte cell derived chemotaxin 1 (LOC100226280)
  • chondromodulin-I precursor (CHM-I)
  • leukocyte cell derived chemotaxin 1 (Lect1)
  • Bricd3 protein
  • Chm-1 protein
  • ChM-I protein
  • CHM1 protein
  • chondromodulin-I protein
  • Lect1 protein
  • MGC53801 protein
  • MGC82444 protein
  • MYETS1 protein

Protein level used designations for LECT1

leukocyte cell derived chemotaxin 1 , chondromodulin-I , chondromodulin-1-like , chondromodulin-1 , leukocyte cell-derived chemotaxin 1 , BRICHOS domain containing 3 , chondromodulin I , multiple myeloma tumor suppressor 1 , SCGP , small cartilage-derived glycoprotein , Chondromodulin 1 , chM-I

GENE ID SPECIES
379773 Xenopus laevis
446632 Xenopus laevis
694189 Macaca mulatta
735744 Pan troglodytes
100037893 Xenopus (Silurana) tropicalis
100226280 Taeniopygia guttata
100408687 Callithrix jacchus
100455694 Pongo abelii
100008692 Oryctolagus cuniculus
11061 Homo sapiens
395600 Gallus gallus
281683 Bos taurus
16840 Mus musculus
81512 Rattus norvegicus
609613 Canis lupus familiaris
100734572 Cavia porcellus
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