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LECT2 encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. Additionally we are shipping LECT2 Antibodies (49) and LECT2 Kits (14) and many more products for this protein.
Showing 9 out of 9 products:
Localized LECT2 amyloidosis of the adrenal gland with coexisting MGUS: a diagnostic challenge.
LECT2 immunostain is useful in confirming subtype of amyloid within the liver in ALECT2..
There were no mutations detected in the LECT2 gene, although all renal leukocyte chemotactic factor 2 amyloidosis patients tested were homozygous for the G nucleotide in a non-synonymous SNP at position 172.
LECT2 is regulated by beta-catenin (show CTNNB1 Proteins) in HCC (show FAM126A Proteins) in both mice and men, but serum LECT2 reflects beta-catenin (show CTNNB1 Proteins) activity only in mice. Serum LECT2 could be a potential biomarker of HCC (show FAM126A Proteins) in patients.
First Nations people from British Columbia who presented with chronic kidney disease, were found to be due to LECT2 amyloidosis.
The study indicates that serum LECT2 levels are increased by obesity and fatty liver, and suggests that LECT2 is a novel obesity-related protein.
The data from this study show that weak LECT2 staining should be regarded as indeterminate or a negative result and does not per se allow diagnosis of specific amyloid type. The diagnosis of LECT2 renal amyloidosis (show LYZ Proteins) may require LMD/MS confirmation.
These results demonstrate the involvement of LECT2 in glucose metabolism and suggest that LECT2 may be a therapeutic target for obesity-associated insulin (show INS Proteins) resistance.
These findings reveal a novel, specific inhibitory function of LECT2 in hepatocellular carcinoma by the direct binding and inactivation of MET.
preliminary X-ray analysis of human leukocyte cell-derived chemotaxin 2 (LECT2).
LECT2 improves protective immunity in bacterial sepsis, possibly as a result of enhanced macrophages functions via the CD209a receptor.
Zinc stabilizes the LECT2 structure.
Data suggest the involvement of LECT2 in the regulation of fatal SEA (show Slc25a1 Proteins)-induced toxicity in d-GalN (show GAL Proteins)-sensitized mice.
Our results suggest that LECT2 regulates neuritic extension through microtubular morphallaxis through the control of katanin-P60 (show STIP1 Proteins) levels.
Our results show that LECT2 regulates the extension of axons and dendrites and the expressions of NGF (show NGFB Proteins), BDNF (show BDNF Proteins) and NT-3 (show NTF3 Proteins) during neuronal development.
LECT2, which encodes a protein with chemotactic properties for human neutrophils, is a direct target gene of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in the liver.
LECT2 directly suppresses the development of collagen antibody induced arthritis
This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis.
, leukocyte cell-derived chemotaxin-2
, chondromodulin II
, cell-derived chemotaxin 2
, myeloid protein (mim-1)
, myeloid protein 1