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Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 3 Proteins (LILRB3)

LILRB3 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. Additionally we are shipping Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 3 Antibodies (35) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat LILRB3 LILRB3 65146  
LILRB3 11025 O75022
LILRB3 18733 P97484
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Top Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 3 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$809.60
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$936.27
Details

LILRB3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) , ,
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Top referenced Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 3 Proteins

  1. Mouse (Murine) LILRB3 Protein expressed in Human Cells - ABIN2008283 : Wende, Volz, Ziegler: Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. in Immunogenetics 2000 (PubMed)
    Show all 3 references for ABIN2008283

  2. Human LILRB3 Protein expressed in Human Cells - ABIN2004950 : Arm, Nwankwo, Austen: Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. in Journal of immunology (Baltimore, Md. : 1950) 1997 (PubMed)
    Show all 3 references for ABIN2004950

More Proteins for Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 3 (LILRB3) Interaction Partners

Human Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 3 (LILRB3) interaction partners

  1. RPS9 (show RPS9 Proteins)/LILRB3 (rs11666543) was associated with Takayasu arteritis.

  2. Blockade of LILRB1 (show LILRB1 Proteins) and LILRB3 receptors by monoclonal antibodies or short interfering RNA (siRNA) abrogated the specific antigen-presenting properties of dendritic cells, implying an important regulatory role of these molecules.

  3. Coligation of LIR3 to LIR7 (show LILRA2 Proteins) or to FcepsilonRI (show FCER1G Proteins) by means of a second monoclonal antibody significantly inhibited net histamine release, cysLT production, and IL-4 (show IL4 Proteins) generation. LIR3 is counter-regulatory for both adaptive and innate receptors suggests.

  4. Progenitor mast cells expressed cell surface inhibitory LILRB3. Mature cord-blood-derived mast cells had detectable mRNA encoding multiple LILRs, none were expressed on the cell surface.

  5. LILRB3 is expressed on cultured osteoclast precursor cells derived from peripheral blood monocytes and plays a regulatory role in the development of osteoclasts.

Mouse (Murine) Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 3 (LILRB3) interaction partners

  1. neural plasticity in adult visual cortex is actively repressed and can be enhanced by blocking PirB function.

  2. The Nogo-B (show RTN4 Proteins)-PirB axis controls macrophage-mediated vascular remodeling.

  3. PIRB and LILRB2 (show LILRB2 Proteins) were expressed in mouse and human platelets, respectively.

  4. NogoA (show RTN4 Proteins) receptors, NogoR1 and PirB, are expressed in the ventricular zone where neural stem cells reside.

  5. PirB expression is up-regulated after transient focal cerebral ischaemia. It may play pathologic roles in the inhibition of axonal regeneration after stroke.

  6. PirB normally regulates spine and excitatory synapse density and consequently the threshold for new learning throughout life.

  7. Data indicate a critical role for PIR-B and PIR-A in eosinophil development.

  8. In mice, the deleterious effect of Abeta (show APP Proteins) oligomers on hippocampal long-term potentiation required PirB, and in a transgenic model of Alzheimer's disease, PirB not only contributed to memory deficits present in adult mice, but also mediated loss of synaptic plasticity in juvenile visual cortex.

  9. a key role for PIR-B in IPF, likely via the regulation of macrophage activation

  10. findings, coupled with previous studies, may imply that PirB is probably a critical molecule in inhibition of axonal regeneration by myelin inhibitors after ON injury

Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 3 (LILRB3) Protein Profile

Protein Summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with LILRB3

  • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 (Lilrb3)
  • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like (Lilrb3l)
  • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 (LILRB5)
  • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 (LILRB3)
  • paired Ig-like receptor B (Pirb)
  • CD85A protein
  • Gp91 protein
  • HL9 protein
  • ILT-5 protein
  • ILT5 protein
  • LILRA6 protein
  • LILRB3 protein
  • LIR-3 protein
  • LIR3 protein
  • NILR-1 protein
  • Pir-A1 protein
  • Pir-A2 protein
  • PIR-B protein
  • PIRB protein

Protein level used designations for LILRB3

paired-Ig-like receptor B , type 1 one-pass transmembrane Ig-like receptor , Ig-superfamily activating receptor , leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 , paired Ig-like receptor-A1 , paired Ig-like receptor-A2 , paired Ig-like receptor-B , six Ig-like domains/type I transmembrane , CD85 antigen-like family member A , immunoglobulin-like transcript 5 , leukocyte immunoglobulin-like receptor 3 , leukocyte immunoglobulin-like receptor subfamily B member 3 , leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 , monocyte inhibitory receptor HL9 , cell-surface glycoprotein p91 , paired immunoglobulin-like receptor B

GENE ID SPECIES
65146 Rattus norvegicus
361493 Rattus norvegicus
484306 Canis lupus familiaris
790139 Bos taurus
11025 Homo sapiens
18733 Mus musculus
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