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The protein encoded by KDM5A is a ubiquitously expressed nuclear protein. Additionally we are shipping KDM5A Proteins (4) and KDM5A Kits (1) and many more products for this protein.
Showing 10 out of 72 products:
Human Monoclonal KDM5A Primary Antibody for ELISA, WB - ABIN395221
Ge, Li, Wang, Liu, Zhu, Björkholm, Gruber, Xu: Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
Show all 5 references for ABIN395221
Human Polyclonal KDM5A Primary Antibody for IHC (p), IP - ABIN258184
Tsai, Nguyen, Shi, Barton: p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo. in Molecular and cellular biology 2008
Show all 4 references for ABIN258184
Human Monoclonal KDM5A Primary Antibody for FACS, IF - ABIN3201015
Christensen, Agger, Cloos, Pasini, Rose, Sennels, Rappsilber, Hansen, Salcini, Helin: RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. in Cell 2007
Show all 3 references for ABIN3201015
Treatment-induced temozolimide resistance in glioblastoma cells involves KDM5A mediated epigenetic mechanisms.
Characterization of a Linked Jumonji (show JARID2 Antibodies) Domain of the KDM5/JARID1 Family of Histone H3 (show HIST3H3 Antibodies) Lysine 4 Demethylases.
KDM5A is regulated by its reader domain through a positive-feedback mechanism
Data indicate that lysine (K)-specific demethylase 5A RBP2 (JARID1A; KDM5A) epigenetically downregulated micrRNA-21 (miR (show MLXIP Antibodies)-21) in blast transformation of chronic myeloid leukemia (show BCL11A Antibodies) (CML (show BCR Antibodies)).
LSD1 (show KDM1A Antibodies) is a more sensitive molecular marker than RBP2 on thyroid cancer diagnosis.
MiR (show MLXIP Antibodies)-212 directly regulates the expression of RBP2 and inhibits cell growth in gastric cancer, which may provide new clues to treatment.
RBP2 is critical for breast cancer metastasis to the lung in multiple in vivo models. Mechanistically, RBP2 promotes metastasis as a pleiotropic positive regulator of many metastasis genes, including TNC (show TNC Antibodies).
RBP2 is overexpressed in HCC (show FAM126A Antibodies) and negatively regulated by hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-212. The hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-212-RBP2-CDKI (show CDKN1C Antibodies) pathway may be important in the pathogenesis of HCC (show FAM126A Antibodies).
Overexpression of RBP2 and activation of VEGF might play important roles in human gastric cancer development and progression.
RBP2 is overexpressed in gastric cancer, and its inhibition triggers senescence of malignant cells at least partially by derepressing its target genes cyclin-dependent kinase (show CDK1 Antibodies) inhibitors.
Kdm5a associates with p50 (show LSP1 Antibodies) and binds to the Socs1 (show SOCS1 Antibodies) promoter region in resting natural killer cells.
Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C (show EHMT2 Antibodies) and the H3K4 demethylase (show MBD2 Antibodies) Jarid1a/KDM5A.
In terminally differentiated cells, common KDM5A and E2F4 (show E2F4 Antibodies) gene targets were bound by the pRB (show PGR Antibodies)-related protein p130, a DREAM complex component.
Study reports that RBP2 (show RBP2 Antibodies) is a demethylase (show MBD2 Antibodies) that specifically catalyzes demethylation on histone H3 (show HIST3H3 Antibodies) lysine 4, whose methylation is normally associated with transcriptionally active genes.
JARID1a formed a complex with CLOCK-BMAL1 (show ARNTL Antibodies) which was recruited to Per2 (show PER2 Antibodies) promoter;it increased histone acetylation by inhibiting histone deacetylase 1 (show HDAC1 Antibodies) function and enhanced transcription by CLOCK-BMAL1 (show ARNTL Antibodies); JARID1a depletion shortened period of circadian rhythms
KDM5A interacts physically with RBP-J (show RBPJ Antibodies)
mutation can downregulate cardiac cell proliferation by repressing cyclin D1 (show CCND1 Antibodies) expression in the same way as jumonji (show JARID2 Antibodies)
A functional interplay between the PRC2 complex and the H3K4me3 demethylase (show MBD2 Antibodies) Rbp2 (Jarid1a) in mouse embryonic stem (ES) cells.
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein.
jumonji, AT rich interactive domain 1A (Rbp2 like)
, lysine-specific demethylase 5A
, jumonji, AT rich interactive domain 1A
, lysine (K)-specific demethylase 5A
, JARID1A variant protein-like
, jumonji AT-rich interactive domain 1A
, retinoblastoma binding protein 2
, Jumonji, AT rich interactive domain 1A (RBP2-like)
, histone demethylase JARID1A
, jumonji/ARID domain-containing protein 1A
, retinoblastoma-binding protein 2