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May act as a transcriptional repressor. Additionally we are shipping and many more products for this protein.
Showing 10 out of 42 products:
Human Polyclonal MORC2 Primary Antibody for IP, WB - ABIN153176
Shao, Li, Zhang, Liu, Liu, Zhao, Shen, Li: Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX. in Nucleic acids research 2010
these results demonstrate a cytosolic function of MORC2 in lipogenesis, adipogenic differentiation, and lipid homeostasis by regulating the activity of ACLY (show ACLY Antibodies).[Morc2]
Differential viral accessibility shows that loss of MORC2 results in chromatin decompaction at HUSH complex target loci, concomitant with a loss of H3K9me3 deposition and transcriptional derepression. The ATPase (show DNAH8 Antibodies) activity of MORC2 is critical for HUSH-mediated silencing. The most common alteration affecting the ATPase (show DNAH8 Antibodies) domain in CMT patients (p.Arg252Trp) hyperactivates HUSH-mediated repression in neuronal cells.
have identified a new locus in which MORC2 mutations are the likely pathogenic cause of CMT2 and pyramidal signs in these families.
identified two different mutations in the MORC2 gene in patients from three unrelated families presenting with an axonal motor and sensory neuropathy.
MORC2 down-regulates the ArgBP2 (show Sorbs2 Antibodies) via histone methylation in gastric cancer cells.
MORC2 down-regulated p21 (show CDKN1A Antibodies) by recruiting HDAC1 (show HDAC1 Antibodies) to the p21 (show CDKN1A Antibodies) promoter, in a p53 (show TP53 Antibodies)-independent manner. MORC2 expression correlated negatively with p21 (show CDKN1A Antibodies) expression in gastric tumors in patients.
PAK1 (show PAK1 Antibodies)-mediated MORC2 phosphorylation promotes gastric tumorigenesis
these results demonstrate a cytosolic function of MORC2 in lipogenesis, adipogenic differentiation, and lipid homeostasis by regulating the activity of ACLY (show ACLY Antibodies).
the PAK1 (show PAK1 Antibodies)-MORC2 axis is critical for orchestrating the interplay between chromatin dynamics and the maintenance of genomic integrity through sequentially integrating multiple essential enzymatic processes.
Analysis of MORC2 functional domains, subcellular localization and mRNA and protein expression demonstrates its role of nuclear localization in association with a proline-rich domain regulating gene transcriptional repression in cancer cells.
May act as a transcriptional repressor. Down-regulates CA9 expression.
MORC family CW-type zinc finger protein 2A
, zinc finger CW-type coiled-coil domain protein 1
, zinc finger, CW-type with coiled-coil domain 1
, microrchidia 2A
, MORC family CW-type zinc finger 2
, MORC family CW-type zinc finger protein 2
, zinc finger, CW type with coiled-coil domain 1