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Acts as a transcriptional coactivator for NOTCH proteins. Additionally we are shipping and many more products for this protein.
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Human Polyclonal MAML3 Primary Antibody for ICC, IF - ABIN151567
Köchert, Ullrich, Kreher, Aster, Kitagawa, Jöhrens, Anagnostopoulos, Jundt, Lamprecht, Zimber-Strobl, Stein, Janz, Dörken, Mathas: High-level expression of Mastermind-like 2 contributes to aberrant activation of the NOTCH signaling pathway in human lymphomas. in Oncogene 2011
Show all 2 Pubmed References
Mastermind-like 1 (MamL1 (show MAML1 Antibodies)) and mastermind-like 3 (MamL3) are essential for Notch (show NOTCH1 Antibodies) signaling in vivo.
These findings indicate that the miR (show MLXIP Antibodies)-2392-MAML3/WHSC1 (show WHSC1 Antibodies)-Slug (show SNAI2 Antibodies)/Twist1 (show TWIST1 Antibodies) regulatory axis plays a critical role in GC metastasis.
Results show that overexpression of MAML3 confers resistance to retinoic acid in multiple neuroblastoma (show ARHGEF16 Antibodies) cell lines.
These results suggest that PSK (show TAOK2 Antibodies) suppresses Hedgehog (show SHH Antibodies) signaling through down-regulation of MAML3 and RBPJ (show RBPJ Antibodies) transcription under hypoxia, inhibiting the induction of a malignant phenotype in pancreatic cancer. Our results may lead to development of new treatments for refractory pancreatic cancer using PSK (show TAOK2 Antibodies) as a Hedgehog (show SHH Antibodies) inhibitor
The present study further expands the genetic spectrum of small blue round cell tumors, with 2 novel fusions, BCOR (show BCOR Antibodies)-MAML3 and ZC3H7B (show ZC3H7B Antibodies)-BCOR (show BCOR Antibodies), identified
Suggest that hypoxia promotes SMO transcription through upregulation of MAML3 and RBPJ (show RBPJ Antibodies) to induce proliferation, invasiveness and tumorigenesis in pancreatic cancer.
Identification of new human proteins defines a family that consists of positive regulators for notch (show NOTCH1 Antibodies) signaling
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.
, mastermind-like 3
, glutamine repeat protein 1
, mastermind-like protein 3
, CAG repeat containing (glia-derived nexin I alpha)
, CAG repeat domain
, expanded repeat domain, CAG/CTG 3
, polyglutamine rich
, trinucleotide repeat containing 3
, mastermind-like protein 3-like