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anti-Maternal Embryonic Leucine Zipper Kinase (MELK) Antibodies

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Additionally we are shipping MELK Kits (14) and MELK Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MELK 9833 Q14680
MELK 17279 Q61846
MELK 362510  
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Top anti-MELK Antibodies at antibodies-online.com

Showing 10 out of 119 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-MELK Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: HT1080 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Goat Un-conjugated EIA, WB 20 μg Log in to see 6 to 8 Days
$203.50
Details
Human Rabbit Un-conjugated EIA, WB The anti-MELK Pab is used in Western blot to detect MKEL in HEPG2 tissue lysate 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB The anti-MRLK Pab is used in Western blot to detect MRLK in mouse brain tissue lysate 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated ELISA, WB ABIN184576 (0.1µg/ml) staining of human testes lysate (RIPA buffer, 1.4E5 cells per lane). Detected by western blot using chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated WB The anti-MELK Pab (ABIN391224) is used in Western blot to detect MKEL in HEPG2 tissue lysate 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB The anti-MRLK Pab (ABIN391223) is used in Western blot to detect MRLK in mouse brain tissue lysate 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of MCF-7 cells using MELK mouse mAb (green) and negative control (red) . 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$253.00
Details
Human Rabbit Un-conjugated   100 μg Log in to see 3 to 4 Days
$257.40
Details

MELK Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-MELK Antibodies

  1. Human Monoclonal MELK Primary Antibody for ICC, FACS - ABIN969538 : Nakano, Joshi, Visnyei, Hu, Watanabe, Lam, Wexler, Saigusa, Nakamura, Laks, Mischel, Viapiano, Kornblum: Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway. in Neuro-oncology 2011 (PubMed)
    Show all 2 references for ABIN969538

  2. Human Polyclonal MELK Primary Antibody for WB - ABIN871726 : Seong, Gil, Kim, Kim, Ha: Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38). in The Biochemical journal 2002 (PubMed)
    Show all 2 references for ABIN871726

  3. Human Polyclonal MELK Primary Antibody for WB - ABIN391223 : Davezac, Baldin, Blot, Ducommun, Tassan: Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation. in Oncogene 2002 (PubMed)

  4. Human Polyclonal MELK Primary Antibody for - ABIN2017585 : Hu, Ru, Xiao, Chaturbedi, Hoa, Tian, Zhang, Ke, Yan, Nelson, Li, Gramer, Yu, Siegel, Zhang, Jia, Jadus, Limoli, Linskey, Xing, Zhou: Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity. in PLoS ONE 2013 (PubMed)

  5. Human Polyclonal MELK Primary Antibody for ELISA, WB - ABIN184576 : Nagase, Seki, Ishikawa, Tanaka, Nomura: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. in DNA research : an international journal for rapid publication of reports on genes and genomes 1996 (PubMed)

  6. Cow (Bovine) Polyclonal MELK Primary Antibody for EIA, WB - ABIN782869 : Lin, Park, Nishidate, Nakamura, Katagiri: Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. in Breast cancer research : BCR 2007 (PubMed)

  7. Cow (Bovine) Polyclonal MELK Primary Antibody for WB - ABIN2782538 : Marie, Okamoto, Uno, Hasegawa, Oba-Shinjo, Cohen, Camargo, Kosoy, Carlotti, Toledo, Moreira-Filho, Zago, Simpson, Caballero: Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas. in International journal of cancer. Journal international du cancer 2007 (PubMed)

More Antibodies against MELK Interaction Partners

Human Maternal Embryonic Leucine Zipper Kinase (MELK) interaction partners

  1. targeting MELK by the inhibition of both its catalytic activity and its protein stability might sensitize tumours to DNA-damaging agents or radiation therapy by lowering the DNA-damage threshold

  2. Together, these data indicate that MELK is a normally non-essential kinase, but is critical for basal-like breast cancer.

  3. EZH2 (show EZH2 Antibodies) protects glioma stem cells from radiation-induced cell death in a MELK/FOXM1 (show FOXM1 Antibodies)-dependent manner

  4. we report characterization of possible roles of MELK in acute myeloid leukemia (show BCL11A Antibodies)

  5. insight has been brought by the discovery of a protein complex of FOXM1 (show FOXM1 Antibodies) with the mitotic kinase MELK in cancer stem cells in brain cancers, as this protein complex appears to be cancer-specific

  6. advanced cancers with OTSSP167 started in 2013, as the first-in-class MELK inhibitor. This review summarizes the current molecular understanding of MELK and the recent preclinical studies about MELK as a cancer therapeutic target.

  7. MELK promotes cell migration and invasion via the FAK (show PTK2 Antibodies)/Paxillin (show PXN Antibodies) pathway, and plays an important role in the occurrence and development of gastric cancer.

  8. our current knowledge of MELK function and recent discoveries in MELK signaling pathway were discussed.

  9. The structural and biochemical analyses unravel the molecular mechanisms for the autophosphorylation/activation of MELK and the dependence of its catalytic activity on reducing agents.

  10. glioblastoma cells have elevated MELK protein levels to better cope with replication stress during unperturbed S phase.

Mouse (Murine) Maternal Embryonic Leucine Zipper Kinase (MELK) interaction partners

  1. MELK promotes cell migration and invasion via the FAK (show PTK2 Antibodies)/Paxillin (show PXN Antibodies) pathway, and plays an important role in the occurrence and development of gastric cancer.

  2. Phosphorylation of the activation loop of MPK38 induces its movement resulting in kinase activation.

  3. These results indicate that Trx (show TXN Antibodies) functions as a physiological inhibitor of MPK38, which plays an important role in inducing ASK1 (show MAP3K5 Antibodies)-, TGF-beta (show TGFB1 Antibodies), and p53 (show TP53 Antibodies)-mediated activity

  4. an important role for MPK38-mediated phosphorylation of PDK1 (show PDPK1 Antibodies) in the negative regulation of PDK1 (show PDPK1 Antibodies) activity.

  5. MPK38 may act as a novel regulator for promoting p53 (show TP53 Antibodies) activity through direct phosphorylation of p53 (show TP53 Antibodies) at Ser (show SIGLEC1 Antibodies)(15).

  6. Upregulation of maternal embryonic leucine zipper kinase is associated with mammary tumor.

  7. MELK is necessary for proliferation of embryonic and postnatal MNP and suggest that it regulates the transition from GFAP (show GFAP Antibodies)-expressing progenitors to rapid amplifying progenitors in the postnatal brain.

  8. The characterization of two novel E2F (show E2F1 Antibodies) target genes, chromosome condensation-related SMC-associated protein 1 (Cnap1 (show NCAPD2 Antibodies)) and maternal embryonic leucine zipper kinase (Melk) is reported.

  9. MPK38 physically interacts with ASK1 (show MAP3K5 Antibodies) in vivo and acts as a positive upstream regulator of ASK1 (show MAP3K5 Antibodies)

Zebrafish Maternal Embryonic Leucine Zipper Kinase (MELK) interaction partners

  1. Melk-like gene may play a role in primitive hematopoiesis by affecting the expression of genes critical for hematopoiesis.

Xenopus laevis Maternal Embryonic Leucine Zipper Kinase (MELK) interaction partners

  1. Overexpression of xMELK leads to failure of cytokinesis and impairs accumulation RhoA- a pivotal regulator of cytokinesis.

  2. These results demonstrate the presence of a mitochondrial targeting signal at the N-terminus of the MC domain of MELK. This mitochondrial targeting signal was also functional in human HeLa cells.[MELK]

MELK Antigen Profile

Protein Summary

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis.

Gene names and symbols associated with MELK

  • maternal embryonic leucine zipper kinase (MELK) antibody
  • maternal embryonic leucine zipper kinase (melk) antibody
  • maternal embryonic leucine zipper kinase (cgd5_2270) antibody
  • maternal embryonic leucine zipper kinase (Melk) antibody
  • AI327312 antibody
  • fb71b01 antibody
  • fe01f04 antibody
  • HPK38 antibody
  • Melk antibody
  • mKIAA0175 antibody
  • MPK38 antibody
  • wu:fb71b01 antibody
  • wu:fe01f04 antibody
  • xmelk antibody

Protein level used designations for MELK

maternal embryonic leucine zipper kinase , maternal embryonic leucine zipper kinase-like , pEg3 kinase , protein kinase Eg3 , protein kinase PK38 , tyrosine-protein kinase MELK , zMelk , Protein kinase Eg3

GENE ID SPECIES
428391 Gallus gallus
465095 Pan troglodytes
549144 Xenopus (Silurana) tropicalis
3373320 Cryptosporidium parvum Iowa II
100123808 Nasonia vitripennis
100386947 Callithrix jacchus
100586707 Nomascus leucogenys
9833 Homo sapiens
481608 Canis lupus familiaris
520088 Bos taurus
17279 Mus musculus
362510 Rattus norvegicus
30724 Danio rerio
397927 Xenopus laevis
Selected quality suppliers for anti-MELK (MELK) Antibodies
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