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Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Additionally we are shipping MELK Kits (14) and MELK Proteins (6) and many more products for this protein.
Showing 10 out of 115 products:
Human Monoclonal MELK Primary Antibody for ICC, FACS - ABIN969538
Nakano, Joshi, Visnyei, Hu, Watanabe, Lam, Wexler, Saigusa, Nakamura, Laks, Mischel, Viapiano, Kornblum: Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway. in Neuro-oncology 2011
Show all 2 references for ABIN969538
Human Polyclonal MELK Primary Antibody for WB - ABIN871726
Seong, Gil, Kim, Kim, Ha: Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38). in The Biochemical journal 2002
Show all 2 references for ABIN871726
Human Polyclonal MELK Primary Antibody for WB - ABIN391224
Davezac, Baldin, Blot, Ducommun, Tassan: Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation. in Oncogene 2002
Human Polyclonal MELK Primary Antibody for - ABIN2017585
Hu, Ru, Xiao, Chaturbedi, Hoa, Tian, Zhang, Ke, Yan, Nelson, Li, Gramer, Yu, Siegel, Zhang, Jia, Jadus, Limoli, Linskey, Xing, Zhou: Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity. in PLoS ONE 2013
Human Polyclonal MELK Primary Antibody for ELISA, WB - ABIN184576
Nagase, Seki, Ishikawa, Tanaka, Nomura: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. in DNA research : an international journal for rapid publication of reports on genes and genomes 1996
Cow (Bovine) Polyclonal MELK Primary Antibody for EIA, WB - ABIN782869
Lin, Park, Nishidate, Nakamura, Katagiri: Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. in Breast cancer research : BCR 2007
Cow (Bovine) Polyclonal MELK Primary Antibody for WB - ABIN2782538
Marie, Okamoto, Uno, Hasegawa, Oba-Shinjo, Cohen, Camargo, Kosoy, Carlotti, Toledo, Moreira-Filho, Zago, Simpson, Caballero: Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas. in International journal of cancer. Journal international du cancer 2007
targeting MELK by the inhibition of both its catalytic activity and its protein stability might sensitize tumours to DNA-damaging agents or radiation therapy by lowering the DNA-damage threshold
Together, these data indicate that MELK is a normally non-essential kinase, but is critical for basal-like breast cancer.
EZH2 (show EZH2 Antibodies) protects glioma stem cells from radiation-induced cell death in a MELK/FOXM1 (show FOXM1 Antibodies)-dependent manner
we report characterization of possible roles of MELK in acute myeloid leukemia (show BCL11A Antibodies)
insight has been brought by the discovery of a protein complex of FOXM1 (show FOXM1 Antibodies) with the mitotic kinase MELK in cancer stem cells in brain cancers, as this protein complex appears to be cancer-specific
advanced cancers with OTSSP167 started in 2013, as the first-in-class MELK inhibitor. This review summarizes the current molecular understanding of MELK and the recent preclinical studies about MELK as a cancer therapeutic target.
MELK promotes cell migration and invasion via the FAK (show PTK2 Antibodies)/Paxillin (show PXN Antibodies) pathway, and plays an important role in the occurrence and development of gastric cancer.
our current knowledge of MELK function and recent discoveries in MELK signaling pathway were discussed.
The structural and biochemical analyses unravel the molecular mechanisms for the autophosphorylation/activation of MELK and the dependence of its catalytic activity on reducing agents.
glioblastoma cells have elevated MELK protein levels to better cope with replication stress during unperturbed S phase.
Phosphorylation of the activation loop of MPK38 induces its movement resulting in kinase activation.
These results indicate that Trx (show TXN Antibodies) functions as a physiological inhibitor of MPK38, which plays an important role in inducing ASK1 (show MAP3K5 Antibodies)-, TGF-beta (show TGFB1 Antibodies), and p53 (show TP53 Antibodies)-mediated activity
an important role for MPK38-mediated phosphorylation of PDK1 (show PDPK1 Antibodies) in the negative regulation of PDK1 (show PDPK1 Antibodies) activity.
MPK38 may act as a novel regulator for promoting p53 (show TP53 Antibodies) activity through direct phosphorylation of p53 (show TP53 Antibodies) at Ser (show SIGLEC1 Antibodies)(15).
Upregulation of maternal embryonic leucine zipper kinase is associated with mammary tumor.
MELK is necessary for proliferation of embryonic and postnatal MNP and suggest that it regulates the transition from GFAP (show GFAP Antibodies)-expressing progenitors to rapid amplifying progenitors in the postnatal brain.
The characterization of two novel E2F (show E2F1 Antibodies) target genes, chromosome condensation-related SMC-associated protein 1 (Cnap1 (show NCAPD2 Antibodies)) and maternal embryonic leucine zipper kinase (Melk) is reported.
MPK38 physically interacts with ASK1 (show MAP3K5 Antibodies) in vivo and acts as a positive upstream regulator of ASK1 (show MAP3K5 Antibodies)
Melk-like gene may play a role in primitive hematopoiesis by affecting the expression of genes critical for hematopoiesis.
Overexpression of xMELK leads to failure of cytokinesis and impairs accumulation RhoA- a pivotal regulator of cytokinesis.
These results demonstrate the presence of a mitochondrial targeting signal at the N-terminus of the MC domain of MELK. This mitochondrial targeting signal was also functional in human HeLa cells.[MELK]
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis.
maternal embryonic leucine zipper kinase
, maternal embryonic leucine zipper kinase-like
, pEg3 kinase
, protein kinase Eg3
, protein kinase PK38
, tyrosine-protein kinase MELK
, Protein kinase Eg3