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Matrix Gla Protein Proteins (MGP)

The protein encoded by MGP is secreted and likely acts as an inhibitor of bone formation. Additionally we are shipping Matrix Gla Protein Antibodies (56) and Matrix Gla Protein Kits (45) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MGP 4256 P08493
MGP 17313 P19788
MGP 25333 P08494
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Top Matrix Gla Protein Proteins at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$313.50
Details
HOST_Escherichia coli (E. coli) Rabbit His tag,GST tag 100 μg Log in to see 11 to 13 Days
$880.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,S tag 100 μg Log in to see 11 to 13 Days
$616.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Rat His tag,S tag   100 μg Log in to see 11 to 13 Days
$616.00
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,102.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,123.00
Details

MGP Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)
,
Rat (Rattus) ,
, ,

Top referenced Matrix Gla Protein Proteins

  1. Human MGP Protein expressed in Escherichia coli (E. coli) - ABIN667546 : Cancela, Hsieh, Francke, Price: Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene. in The Journal of biological chemistry 1990 (PubMed)
    Show all 2 references for ABIN667546

More Proteins for Matrix Gla Protein (MGP) Interaction Partners

Xenopus laevis Matrix Gla Protein (MGP) interaction partners

  1. Usefulnees of nonmammalian model systems to elucidate the complex regulation of MGP gene transcription.

  2. These data also indicate that MGP is under dual regulation by runx2 (show RUNX2 Proteins) through the use of various isoforms and context-dependent formation of transcriptional complexes.

Zebrafish Matrix Gla Protein (MGP) interaction partners

  1. MGP is a multi-functional inhibitor of normal and abnormal angiogenesis that may function by coordinating with both Notch and BMP signaling pathways

  2. In contrast with results obtained for previously studied marine fishes, in zebrafish and Senegal sole Mgp accumulates in both calcified tissues and non-mieralized vessel walls of the vascular system.

Human Matrix Gla Protein (MGP) interaction partners

  1. It is assumed that Lp-PLA2 (show Lp-PLA2 Proteins) is involved in vascular calcification and that dp-ucMGP is a more appropriate biomarker of residual risk than Lp-PLA2 (show Lp-PLA2 Proteins) itself.

  2. Data shoed increased GAS6 (show GAS6 Proteins) and decreased MGP levels in hemodialysis patients, as mediators of induction or prevention of vascular calcification.

  3. Altering NOTCH1 (show NOTCH1 Proteins) levels affected MGP mRNA and protein.

  4. Uncarboxylated MGP in synovial fluid might serve as a novel biomarker for assessing knee osteoarthritis progression.

  5. MGP expression is significantly lower in diseased relative to normal aortic valve interstitial cells. Lack of this important "anti-calcification" protein may contribute to calcification of the aortic valve.

  6. Higher plasma dephosphorylated uncarboxylated MGP (reflective of lower vitamin K status) was associated with higher odds of meniscus damage, osteophytes, bone marrow lesions, and subarticular cysts.

  7. High levels of desphospho-uncarboxylated MGP are independently and positively associated with arterial stiffness after adjustment for common cardiovascular risk factors, renal function, and age.

  8. The association has been found between the ischemic atherothrombotic stroke and polymorphic variants of genes MGP and VKORC1 (show VKORC1 Proteins).

  9. MGP expression is impaired in patients with ankylosing spondylitis

  10. The concentration of dephosphorylated-uncarboxylated Matrix Gla protein was higher in hemodialysis patients treated with vitamin K.

Mouse (Murine) Matrix Gla Protein (MGP) interaction partners

  1. loss of MGP causes dysregulation of early endothelial differentiation.

  2. Matrix Gla protein limits pulmonary arteriovenous malformations in ALK1 (show ACVRL1 Proteins) deficiency.

  3. expression of MGP and OCN increased gradually in the murine developing tibial epiphysis, and the two mineral-associated proteins may occur at the same location during a particular period, but at different levels.

  4. Elastin (show ELN Proteins) haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice.

  5. The arterial calcification, not MGP deficiency itself, causes the low bone mass phenotype in Mgp-/- mice.

  6. Two sides of MGP null arterial disease: chondrogenic lesions dependent on transglutaminase 2 (show TGM2 Proteins) and elastin (show ELN Proteins) fragmentation associated with induction of adipsin (show CFD Proteins).

  7. MGP is a multi-functional inhibitor of normal and abnormal angiogenesis that may function by coordinating with both Notch and BMP signaling pathways

  8. Mgp gene deletion may have a role in arteriovenous malformations

  9. MGP is a known inhibitor of mineralization, and mice deficient in Mgp show severe vascular calcification and premature bone mineralization.

  10. Inorganic phosphate(Pi) regulates MGP expression in growth plate chondrocytes, thereby suggesting a key role for Pi and ERK1/2 in the regulation of bone formation.

Pig (Porcine) Matrix Gla Protein (MGP) interaction partners

  1. High DNA methylation (show HELLS Proteins) resulting in the down regulation of matrix Gla protein is associated with osteochondrosis.

Cow (Bovine) Matrix Gla Protein (MGP) interaction partners

  1. Selective CaSR (show CASR Proteins) activation, either by extracellular calcium or AMG (show AMELX Proteins) 641, increased MGP expression in vivo in the arterial wall and in vitro in bovine vascular smooth muscle cells.

  2. the effect of MGP on calcification and osteogenic differentiation is determined by availability of BMP-2 (show BMP2 Proteins)

  3. MGP plays a role in endothelial cell function, by increasing transforming growth factor-beta1 activity and stimulating VEGF expression

  4. MGP has a novel binding activity for vitronectin (show VTN Proteins)

  5. Heat shock protein 70 (show HSP70 Proteins) enhances vascular bone morphogenetic protein-4 (show BMP4 Proteins) signaling by binding matrix Gla protein.

Matrix Gla Protein (MGP) Protein Profile

Protein Summary

The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Matrix Gla Protein Proteins (MGP)

  • matrix Gla protein (mgp-A)
  • matrix Gla protein (mgp)
  • matrix Gla protein (MGP)
  • matrix Gla protein (LOC100136171)
  • matrix Gla protein (LOC100136434)
  • Matrix Gla protein (mgp)
  • matrix Gla protein (Mgp)
  • matrix Gla protein-like (LOC100856382)
  • LOC100136434 protein
  • Mglap protein
  • mgp protein
  • mgp-A protein
  • NTI protein

Protein level used designations for Matrix Gla Protein Proteins (MGP)

matrix Gla protein , Matrix Gla protein , cell growth-inhibiting gene 36 protein , matrix gamma-carboxyglutamate (gla) protein

GENE ID SPECIES
373621 Xenopus laevis
402937 Danio rerio
465310 Pan troglodytes
574116 Macaca mulatta
611039 Canis lupus familiaris
100136171 Oncorhynchus mykiss
100136434 Salmo salar
100195997 Salmo salar
4256 Homo sapiens
17313 Mus musculus
25333 Rattus norvegicus
100008989 Oryctolagus cuniculus
100734539 Cavia porcellus
397206 Sus scrofa
282660 Bos taurus
395912 Gallus gallus
101106925 Ovis aries
100171893 Pongo abelii
102003225 Chinchilla lanigera
100856382 Canis lupus familiaris
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