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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP12 Kits (50) and MMP12 Proteins (30) and many more products for this protein.
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Human Polyclonal MMP12 Primary Antibody for EIA, IHC (p) - ABIN358685
Nar, Werle, Bauer, Dollinger, Jung: Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor. in Journal of molecular biology 2001
Show all 4 references for ABIN358685
Human Polyclonal MMP12 Primary Antibody for IF, IHC (p) - ABIN390136
Shapiro, Kobayashi, Ley: Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. in The Journal of biological chemistry 1993
Show all 3 references for ABIN390136
Human Polyclonal MMP12 Primary Antibody for WB - ABIN223237
Ikonomidis, Jones, Barbour, Stroud, Clark, Kaplan, Zeeshan, Bavaria, Gorman, Spinale, Gorman: Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves. in The Journal of thoracic and cardiovascular surgery 2007
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MMP12 causes arterial stiffening in mice and suggest that it functions similarly in humans.
These results suggest that MMP-12 production during emphysema exacerbation results in increased mortality and disease progression.
study found significant increases of MMP-3 (show MMP3 Antibodies) and MMP-12 mRNA levels and MMP12 zymographic activities in response to Cryptococcus neoformans infection but not C. gattii infection
The results suggest that pulmonary C fiber involvement in long-term airway inflammation and airway hyperresponsiveness occurred at least partially via modulating MMP-12, and the activation of PAR2 (show F2RL1 Antibodies) might be related to MMP-12 production.
MMP-12 up-regulation mediated by SARM (show SARM1 Antibodies)-TRIF (show RNF138 Antibodies) signaling pathway contributes to IFN-gamma (show IFNG Antibodies)-independent airway inflammation and AHR (show AHR Antibodies) post RSV infection in nude mice.
MMP-12 and MMP-13 (show MMP13 Antibodies) alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.
Post-MI, MMP-12i impaired CD44 (show CD44 Antibodies)-HA interactions to suppress neutrophil apoptosis and prolong inflammation, which worsened LV function.
MMP12 upregulated in regenerating motor neurons of the mouse and rat facial nucleus; findings point to a role of MMP12 in the neuronal initiation of the synaptic stripping process
abnormal neuronal expression of matrix metalloproteinase-12 may contribute to axonal degeneration in Niemann-Pick type C disease
the results of this study show a close correlation between vascular injury markers, Arg 1 (show ARG1 Antibodies)+ macrophage accumulation and fibrosis and suggest an important role of MMP-12 in regulating these processes.
Productive complex between MMP-12 and synthetic triple-helical collagen V, are revealed through paramagnetic NMR.
These results proved that MMP-12 expression was increased in cutaneous melanoma and associated with tumor progression. It also provided the first evidence that MMP-12 level could be an independent prognostic marker for patients with cutaneous melanoma
Patients with Primary Open-Angle Glaucoma are characterized by an increased mRNA expression of MMP1 (show MMP1 Antibodies), MMP9 (show MMP9 Antibodies), MMP12, TIMP1 (show TIMP1 Antibodies) and IL-1b (show IL1B Antibodies) genes as compared to the control group .
fluid shear stress induces the synthesis of Insulin growth factor-2 and vascular endothelial growth factor (VEGF) B and D, which in turn transactivate MMP-12.
AG and GG genotypes of the MMP12 rs2276109 variant were significantly under-represented among patients with non-contact anterior cruciate ligament rupture compared to controls.
findings showed that there was an important joint effect of the MMP-12 polymorphisms and Type 2 Diabetes Mellitus on the risk of Ischemic Stroke and therefore it can be considered as a potential marker of cerebrovascular disorders in diabetic patients.
HnRNP K (show HNRNPK Antibodies) can induce MMP12 expression and enzyme activity through activating MMP12 promoter, which promotes cell migration and invasion in nasopharyngeal carcinoma cells.
We identified a novel association with an MMP12 locus in large artery atherosclerosis (rs660599; p = 2.5x10), with independent replication in a second population
Thrombin (show F2 Antibodies)-activated microglia expression of tumor necrosis factor (show TNF Antibodies)-a (show GTF3A Antibodies), interleukin-1b and MMP-12 was significantly reduced through contact-dependent and paracrine mechanisms when the HAESCs were co-cultured with microglia cells
Gene expression profiling performed on tissues obtained from pulmonary sarcoidosis patients identified MMP12 as a potential pathogenic mediator of lung damage and/or remodeling and may serve as a marker for this disease.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
matrix metallopeptidase 12 (macrophage elastase)
, matrix metalloproteinase 12
, macrophage elastase
, macrophage metalloelastase
, matrix metalloproteinase-12
, matrix metalloproteinase 12 (macrophage elastase)
, macrophage metalloelastase MMP-12