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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP20 Kits (9) and MMP20 Proteins (7) and many more products for this protein.
Showing 10 out of 74 products:
Human Polyclonal MMP20 Primary Antibody for IF (p), IHC (p) - ABIN714761
Ogbureke, Koli, Saxena: Matrix Metalloproteinase 20 Co-expression With Dentin Sialophosphoprotein in Human and Monkey Kidneys. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2016
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Human Polyclonal MMP20 Primary Antibody for EIA, IHC (p) - ABIN358692
Llano, Pendás, Knäuper, Sorsa, Salo, Salido, Murphy, Simmer, Bartlett, López-Otín: Identification and structural and functional characterization of human enamelysin (MMP-20). in Biochemistry 1998
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DSPP (show DSPP Antibodies)-MMP20 pair may play a role in the normal turnover of cell surface proteins and/or repair of pericellular matrix proteins of the basement membranes in the metabolically active duct epithelial system of the nephrons.
Levels of matrix metalloproteinases MMP-19 (show MMP19 Antibodies) and MMP-20 expression are significantly increased in pancreatic ductal adenocarcinoma (PDAC).
The expression of MMP20 was lower in calcifying cystic odontogenic tumor when compared to all tumors and cysts.
The growth of choroidal neovascularization in AMD (show AMD1 Antibodies) would be affected by 2 genes: MMP20, a newly confirmed gene expressed in the retina, and ARMS2 (show ARMS2 Antibodies)/HTRA1 (show HTRA1 Antibodies), a well-known susceptibility gene for AMD (show AMD1 Antibodies).
Novel homozygous mutation MMP20 (c.1054G>A, p.Glu352Lys) genes were identified in amelogenesis imperfect consanguinity. Mutant MMP20 was expressed at a normal level but secreted only minimally with proteolytic function.
expression of MMP-20 and co-expression and potential interaction with DSPP (show DSPP Antibodies) in human major salivary gland tissues
In absolute mRNA levels, significant differences were found in expression of MMP2, MMP24, and MMP25 in gastric carcinoma compared with superficial gastritis.
The results identify MMP-20 as a broad activator of pro-KLKs, suggesting the potential for intersection of the KLK and MMP axes under pathological dysregulation of MMP-20 expression.
Polymorphisms of MMP7 (show MMP7 Antibodies) and MMP20 genes may be surrogate markers to predict long-term outcomes after kidney transplantation.
IL-2 (show IL2 Antibodies)-upregulated MT6 (show PRSS33 Antibodies) cell-surface expression correlates with CD16 (show CD16 Antibodies) downmodulation. MT6 (show PRSS33 Antibodies), sequestered in intracellular compartments in unstimulated NK cells, translocates to the effector-target cell interface of CD16 (show CD16 Antibodies)-mediated immunological synapses.
MMP20 in a common ancestor of tetrapods might have been recruited for the processing of AMEL (show AMELX Antibodies) and conserved over 350 million years of evolution.
this study shows that Mmp25-null mice exhibit a defective innate immune response characterized by low sensitivity to bacterial LPS (show TLR4 Antibodies), hypergammaglobulinemia, and reduced secretion of proinflammatory molecules
MMP-20 action guides the growth morphology of the forming hydroxyapatite crystals and enhances their crystallinity.
Matrix metalloproteinase-20 over-expression is detrimental to enamel development
MMP20 cleaves extracellular domains of cadherin adherens junction proteins, both E- and N-cadherin (show CDH2 Antibodies) transcripts are expressed at significantly higher levels in Mmp20 null mice; in Mmp20 ablated mice N-cadherin (show CDH2 Antibodies) expression persists during maturation stage
enamel of M180Tg/AmelxKO mice was thinner than WT, it had similar mechanical properties and decussating enamel prisms, which were abolished by the loss of MMP20 in the M180Tg/DKO mice.
MMP20 may influence ameloblast developmental progression through hydrolysis of cadherin extracellular domains with associated release of transcription factor(s).
Effect of kallikrein 4 (show KLK4 Antibodies) loss on enamel mineralization: comparison with mice lacking matrix metalloproteinase 20.
Runx2 (show RUNX2 Antibodies) regulates the expression of ODAM (show ODAM Antibodies) and nuclear ODAM (show ODAM Antibodies) serves an important regulatory function in the mineralization of enamel through the regulation of MMP-20 apart from a different, currently unidentified, function of extracellular ODAM (show ODAM Antibodies).
These data suggest MMP-25 is a direct transcriptional target for TGF-beta3 (show TGFB3 Antibodies) in mouse secondary palate development and could be a target for TGF-beta3 (show TGFB3 Antibodies) elsewhere as well.
expression of MMP-20 correlates with the stage-associated changes in the digestion of enamel proteins
MMP-20 is the enzyme that processes ameloblastin (show AMBN Antibodies) during the secretory stage of amelogenesis
MMP-20 processes dental sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.
, matrix metalloproteinase 20 (enamelysin)
, matrix metalloproteinase-20
, matrix metallopeptidase-like 1
, matrix metalloproteinase 20
, matrix metalloproteinase 25
, matrix metalloproteinase-25
, matrix metalloproteinase-like 1
, membrane-type 6 matrix metalloproteinase
, membrane-type matrix metalloproteinase 6
, membrane-type-6 matrix metalloproteinase
, matrix metallopeptidase 20 (enamelysin)
, matrix metallopeptidase 25
, matrix metallopeptidase 20
, matrix metalloproteinase