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Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Additionally we are shipping MCAM Proteins (31) and MCAM Kits (26) and many more products for this protein.
Showing 10 out of 474 products:
Human Monoclonal MCAM Primary Antibody for EIA, FACS - ABIN119672
Möbius-Winkler, Hilberg, Menzel, Golla, Burman, Schuler, Adams: Time-dependent mobilization of circulating progenitor cells during strenuous exercise in healthy individuals. in Journal of applied physiology (Bethesda, Md. : 1985) 2009
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Human Monoclonal MCAM Primary Antibody for IF, WB - ABIN968422
Anfosso, Bardin, Francès, Vivier, Camoin-Jau, Sampol, Dignat-George: Activation of human endothelial cells via S-endo-1 antigen (CD146) stimulates the tyrosine phosphorylation of focal adhesion kinase p125(FAK). in The Journal of biological chemistry 1998
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Human Monoclonal MCAM Primary Antibody for FACS - ABIN4896787
Fujinaga, Baker, Ryan, Markham, Seedorf, Balasubramaniam, Abman: Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants. in American journal of physiology. Lung cellular and molecular physiology 2009
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Human Polyclonal MCAM Primary Antibody for EIA, WB - ABIN453743
Malyszko, Malyszko, Kozminski, Pawlak, Mysliwiec: Adipokines, linking adipocytes and vascular function in hemodialyzed patients, may also be possibly related to CD146, a novel adhesion molecule. in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2008
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Human Monoclonal MCAM Primary Antibody for FACS - ABIN4896789
Pilz, Braun, Ulrich, Felka, Warstat, Ruh, Schewe, Abele, Larbi, Aicher: Human mesenchymal stromal cells express CD14 cross-reactive epitopes. in Cytometry. Part A : the journal of the International Society for Analytical Cytology 2011
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Human Monoclonal MCAM Primary Antibody for IHC, ELISA - ABIN1724898
Wang, Yan: CD146, a multi-functional molecule beyond adhesion. in Cancer letters 2013
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Human Monoclonal MCAM Primary Antibody for FACS, IHC - ABIN1724844
Jouve, Despoix, Espeli, Gauthier, Cypowyj, Fallague, Schiff, Dignat-George, Vély, Leroyer: The involvement of CD146 and its novel ligand Galectin-1 in apoptotic regulation of endothelial cells. in The Journal of biological chemistry 2013
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Human Monoclonal MCAM Primary Antibody for FACS - ABIN4896783
Albert, Veréb, Csomós, Moe, Johnsen, Olstad, Nicolaissen, Rajnavölgyi, Fésüs, Berta, Petrovski: Cultivation and characterization of cornea limbal epithelial stem cells on lens capsule in animal material-free medium. in PLoS ONE 2012
Chicken Monoclonal MCAM Primary Antibody for FACS, IHC (fro) - ABIN371423
Vainio, Dunon, Aïssi, Dangy, McNagny, Imhof: HEMCAM, an adhesion molecule expressed by c-kit+ hemopoietic progenitors. in The Journal of cell biology 1997
Rat (Rattus) Monoclonal MCAM Primary Antibody for FACS - ABIN4896084
Shen, Chung, Irhimeh, Li, Lee, Gillies: Systemic administration of erythropoietin inhibits retinopathy in RCS rats. in PLoS ONE 2014
CD146 regulates convergent extension movement during gastrulation
In addition to the physiological angiogenesis during development, gicerin morphants efficiently blocked the tumor angiogenesis in zebrafish.
CD146 protein expression has a role in vascular development in zebrafish
METCAM/MUC18 positively promotes tumorigenesis of human breast cancer SK-BR-3 cells via increasing the signal in survival and proliferation pathways.
sCD146 levels are elevated in patients with systemic sclerosis, but decreased sCD146 levels are observed in SSc (show CYP11A1 Antibodies) patients with pulmonary arterial hypertension
Nestin (show NES Antibodies) and CD146 are expressed in breast cancer cells with highly aggressive potency. They might contribute to disease relapse in breast cancer by activating the epithelial-mesenchymal transition pathway and assist tumor neovascularization.
highlight MCAM and LAMA4 (show LAMa4 Antibodies) as prime candidates for RCC (show XRCC1 Antibodies) prognosis and therapeutic targeting
The results demonstrated isolation of specific scFv with frequency of 40 % which showed significant binding with the epitope in both ELISA and fluorescence-activated cell sorting (FACS) analyses. The antibody inhibited the migration (76 %) and invasion (67 %) of MUC18 positive cell line. The results suggest the specific anti-MUC18 scFv as an effective antibody for breast cancer immunotherapy
We provide the first report that pro-angiogenic genes PECAM1 (show PECAM1 Antibodies), PTGS1 (show PTGS1 Antibodies), FGD5 (show FGD5 Antibodies), and MCAM may play a vital role in pathological dermal angiogenesis disorders of psoriasis.
Results showed that increased human METCAM/MUC18 expression in ovarian cancer SK-OV-3 cells suppressed tumorigenesis and ascites formation in nude mice, suggesting that human METCAM/MUC18 plays a suppressor role in the progression of ovarian cancer, perhaps by reducing proliferation and angiogenesis.
CD146 dexpression efines a subpopulation of human mesenchymal stem cells capable of bone formation and in vivo trans-endothelial migration.
Results showed that CD146 promoted metastasis of hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cells and predicted poor prognosis of HCC (show FAM126A Antibodies) patients. CD146 induced epithelial mesenchymal transition through probably IL-8 (show IL8 Antibodies) up-regulation and STAT1 (show STAT1 Antibodies) down-regulation.
Data indicate that CD146 antigen is an effective cell surface marker for enriching tumor-propagating cells (TPCs) in primary sarcomas.
Microphthalmia-associated transcription factor (show MITF Antibodies) regulates skin melanoblast migration by repressing the melanoma cell adhesion molecule
Data show that CD146 was significantly higher expressed on tumor endothelium than on the liver.
Conditional knockout of the cd146 gene in the murine endothelium or disruption of netrin-CD146 interaction by a specific anti-CD146 antibody blocks or reduces netrin-1 (show NTN1 Antibodies)-induced angiogenesis.
MCAM is expressed by encephalitogenic CD8 (show CD8A Antibodies)+ T lymphocytes in experimental autoimmune encephalomyelitis. Blocking or depleting MCAM in vivo reduces chronic neurological deficits in active, transfer, and spontaneous progressive EAE models.
Study demonstrate for the fi rst (show SLC22A12 Antibodies) time that host CD146 contributes to hematogenous melanoma cell metastasis through a novel mechanism involving the VEGF (show VEGFA Antibodies)/FAK (show PTK2 Antibodies)/Ve-cadherin (show CDH5 Antibodies) network.
Suggest endothelial CD146 as a target for specific drug delivery in hepatocellular carcinoma.
CD146 plays a dual role on endothelium, facilitating leukocyte extravasations and angiogenesis, thus promoting inflammation.
CD146 deletion in the nervous system impairs appetite, locomotor activity and spatial learning in mice.
Identified a novel negative regulator of angiogenesis, microRNA 329 (miR (show MLXIP Antibodies)-329), that directly targeted CD146 and inhibited CD146-mediated angiogenesis in vitro and in vivo.
Alterations in CD146 are involved in the basic etiology of COPD (show ARCN1 Antibodies)/pulmonary emphysema.
expression of FLK1 (show KDR Antibodies), CD146 and microvessel density of angiogenesis at the first week of reperfused acute myocardial infarction.
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
cell surface glycoprotein MUC18
, melanoma adhesion molecule
, cell adhesion molecule
, similar to melanoma cell adhesion molecule
, melanoma cell adhesion molecule
, cell surface glycoprotein MUC18-like
, S-endo 1 endothelial-associated antigen
, cell surface glycoprotein P1H12
, melanoma-associated antigen A32
, melanoma-associated antigen MUC18
, l-gicerin protein