anti-Melanoma Cell Adhesion Molecule (MCAM) Antibodies

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Additionally we are shipping MCAM Kits (32) and MCAM Proteins (25) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MCAM 4162 P43121
MCAM 78967 Q9EPF2
MCAM 84004 Q8R2Y2
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Top anti-MCAM Antibodies at antibodies-online.com

Showing 10 out of 576 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of MCAM Antibody 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- CD146 antibody, Western blotting All lanes: Anti CD146  at 0.5ug/ml Lane 1: A375 Whole Cell Lysate at 40ug Lane 2: HELA Whole Cell Lysate at 40ug Lane 3: HEPG2 Whole Cell Lysate at 40ug Predicted bind size: 72KD Observed bind size: 100KD Anti- CD146 antibody, IHC(P) IHC(P): Human Lung Cancer Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details
Rat Mouse PE FACS Detection of MCAM/CD146 in PC-12 Rat Cell Line by Flow Cytometry. PC-12 rat adrenal pheochromocytoma cell line was stained with Mouse Anti-Rat MCAM/CD146 PE-conjugated Monoclonal Antibody. Detection of MCAM/CD146 in PC-12 Rat Cell Line by Flow Cytometry. PC-12 rat adrenal pheochromocytoma cell line was stained with Mouse Anti-Rat MCAM/CD146 PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$372.75
Details
Human Rabbit Un-conjugated FACS, IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human cervical carcinoma labeled with Anti-CD146/MCAM Polyclonal Antibody, Unconjugated (ABIN732143) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain labeled with Anti-CD146/MCAM Polyclonal Antibody, Unconjugated (ABIN732143) at 1:400 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$307.45
Details
Chicken Mouse Un-conjugated FACS, IHC (fro), IP 0.5 mg Log in to see 6 to 8 Days
$357.50
Details
Human Mouse Un-conjugated FACS, IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$430.10
Details
Human Mouse Un-conjugated IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$430.10
Details
Human Mouse FITC EIA, FACS, IHC (fro)   0.1 mg Log in to see 6 to 8 Days
$533.50
Details
Human Mouse PE FACS Detection of MCAM/CD146 in HeLa Human Cell Line by Flow Cytometry. HeLa human cervical epithelial carcinoma cell line was stained with Mouse Anti-Human MCAM/CD146 PE-conjugated Monoclonal Antibody. Detection of MCAM/CD146 in HeLa Human Cell Line by Flow Cytometry. HeLa human cervical epithelial carcinoma cell line was stained with Mouse Anti-Human MCAM/CD146 PE-conjugated Monoclonal Antibody. 25 Tests Log in to see 8 to 9 Days
$168.00
Details

MCAM Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-MCAM Antibodies

  1. Human Monoclonal MCAM Primary Antibody for FACS - ABIN4896788 : Fujinaga, Baker, Ryan, Markham, Seedorf, Balasubramaniam, Abman: Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants. in American journal of physiology. Lung cellular and molecular physiology 2009 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal MCAM Primary Antibody for FACS - ABIN4896787 : Liu, Shi, Deng, Tang, Zhang, Liu, Ding, Liu, Liu, Shi, Liu, Jin: High levels of β-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal MCAM Primary Antibody for IF, WB - ABIN968422 : Anfosso, Bardin, Francès, Vivier, Camoin-Jau, Sampol, Dignat-George: Activation of human endothelial cells via S-endo-1 antigen (CD146) stimulates the tyrosine phosphorylation of focal adhesion kinase p125(FAK). in The Journal of biological chemistry 1998 (PubMed)
    Show all 4 Pubmed References

  4. Dog (Canine) Monoclonal MCAM Primary Antibody for IHC (f), ICC - ABIN2749195 : Solovey, Gui, Chang, Enenstein, Browne, Hebbel: Identification and functional assessment of endothelial P1H12. in The Journal of laboratory and clinical medicine 2001 (PubMed)
    Show all 3 Pubmed References

  5. Dog (Canine) Monoclonal MCAM Primary Antibody for IHC (f), ICC - ABIN2749196 : Solovey, Lin, Browne, Choong, Wayner, Hebbel: Circulating activated endothelial cells in sickle cell anemia. in The New England journal of medicine 1997 (PubMed)
    Show all 3 Pubmed References

  6. Human Monoclonal MCAM Primary Antibody for FACS, IHC - ABIN1724844 : Wang, Yan: CD146, a multi-functional molecule beyond adhesion. in Cancer letters 2013 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal MCAM Primary Antibody for IHC, ELISA - ABIN1724898 : Jouve, Despoix, Espeli, Gauthier, Cypowyj, Fallague, Schiff, Dignat-George, Vély, Leroyer: The involvement of CD146 and its novel ligand Galectin-1 in apoptotic regulation of endothelial cells. in The Journal of biological chemistry 2013 (PubMed)
    Show all 2 Pubmed References

  8. Human Monoclonal MCAM Primary Antibody for FACS - ABIN4896789 : Pilz, Braun, Ulrich, Felka, Warstat, Ruh, Schewe, Abele, Larbi, Aicher: Human mesenchymal stromal cells express CD14 cross-reactive epitopes. in Cytometry. Part A : the journal of the International Society for Analytical Cytology 2011 (PubMed)
    Show all 2 Pubmed References

  9. Human Monoclonal MCAM Primary Antibody for FACS - ABIN4896790 : White, Rämer, Naresh, Meixlsperger, Pinaud, Rooney, Savoldo, Coutinho, Bödör, Gribben, Ibrahim, Bower, Nourse, Gandhi, Middeldorp, Cader, Murray, Münz, Allday: EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors. in The Journal of clinical investigation 2012 (PubMed)
    Show all 2 Pubmed References

  10. Human Monoclonal MCAM Primary Antibody for FACS - ABIN2478527 : Harper, MacInnes, Campbell, Hall: Increased birth weight in northerly islands: is fish consumption a red herring? in BMJ (Clinical research ed.) 1991 (PubMed)
    Show all 4 Pubmed References

More Antibodies against MCAM Interaction Partners

Human Melanoma Cell Adhesion Molecule (MCAM) interaction partners

  1. CD146 was expressed in all cases of Ph-positive B- cell acute lymphoblastic leukemia and in the vast majority of T-cell acute lymphoblastic leukemia

  2. Our results suggest that MCAM may serve as a novel therapeutic target to overcome chemoresistance in SCLC.

  3. Authors show that KDM3A (show KDM3A Antibodies) regulates MCAM expression both through a direct mechanism, involving modulation of H3K9 methylation at the MCAM promoter, and an indirect mechanism, via the Ets1 (show ETS1 Antibodies) transcription factor.

  4. increment of CD146 expression indicates gradual change of cultured annulus fibrosus cells to express a contractile phenotype and that transforming growth factor beta1 enhances this cellular commitment

  5. CD146 positivity in immunohistological analysis of 11 MRT patient samples was associated with poor patient outcomes. These results suggest that CD146 defines a distinct sub-population in MRT with high tumorigenic capacity and that this marker represents a promising therapeutic target.

  6. Promoter methylation of MCAM, ERalpha and ERbeta have a potential to be utilized as biomarker for the early detection of prostate cancer (PC) as their sensitivity and specificity seem to be better than serum PSA.

  7. MCAM promotes tamoxifen resistance by transcriptionally suppressing ERalpha (show ESR1 Antibodies) expression and activating the AKT (show AKT1 Antibodies) pathway, followed by induction of epithelial-mesenchymal transition.

  8. High MCAM expression is associated with lung metastasis in malignant melanoma.

  9. Results provide evidence that MUC18 promotes viral infections both in vivo and in vitro.

  10. soluble CD146 is released from the peripheral vasculature in response to venous stretch and may reflect systemic congestion in chronic heart failure patients

Mouse (Murine) Melanoma Cell Adhesion Molecule (MCAM) interaction partners

  1. Activation of the proteolytic processing of short isoform CD146, in particular by soluble CD146, constitutes a promising pathway to improve endothelial progenitors' regenerative properties for the treatment of cardiovascular diseases.

  2. Study shows that Mcam is upregulated in cells that have a migratory phenotype upon MEIS1 (show MEIS1 Antibodies) overexpression and identi fi ed a MEIS1 (show MEIS1 Antibodies) consensus site 113 kb upstream of the Mcam tran- scriptional start site.

  3. Different intrinsic co-factors in different K1735 sublines, which modulate the functions of MCAM/MUC18 in the cells that interact differently to the tumor microenvironment, may render sublines manifest differently in tumorigenicity and metastasis in vivo.

  4. Results provide evidence that MUC18 promotes viral infections both in vivo and in vitro.

  5. Microphthalmia-associated transcription factor (show MITF Antibodies) regulates skin melanoblast migration by repressing the melanoma cell adhesion molecule

  6. Data show that CD146 was significantly higher expressed on tumor endothelium than on the liver.

  7. Conditional knockout of the cd146 gene in the murine endothelium or disruption of netrin-CD146 interaction by a specific anti-CD146 antibody blocks or reduces netrin-1 (show NTN1 Antibodies)-induced angiogenesis.

  8. MCAM is expressed by encephalitogenic CD8 (show CD8A Antibodies)+ T lymphocytes in experimental autoimmune encephalomyelitis. Blocking or depleting MCAM in vivo reduces chronic neurological deficits in active, transfer, and spontaneous progressive EAE models.

  9. Study demonstrate for the fi rst (show SLC22A12 Antibodies) time that host CD146 contributes to hematogenous melanoma cell metastasis through a novel mechanism involving the VEGF (show VEGFA Antibodies)/FAK (show PTK2 Antibodies)/Ve-cadherin (show CDH5 Antibodies) network.

  10. Suggest endothelial CD146 as a target for specific drug delivery in hepatocellular carcinoma.

Pig (Porcine) Melanoma Cell Adhesion Molecule (MCAM) interaction partners

  1. expression of FLK1 (show KDR Antibodies), CD146 and microvessel density of angiogenesis at the first week of reperfused acute myocardial infarction.

MCAM Antigen Profile

Protein Summary

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Gene names and symbols associated with MCAM

  • melanoma cell adhesion molecule (MCAM) antibody
  • melanoma cell adhesion molecule (Mcam) antibody
  • 1-gicerin antibody
  • AV025631 antibody
  • CD146 antibody
  • CD149 antibody
  • MCAM antibody
  • Muc18 antibody
  • s-endo antibody
  • s-gicerin antibody

Protein level used designations for MCAM

Gicerin , S-endo 1 endothelial-associated antigen , cell surface glycoprotein MUC18 , cell surface glycoprotein P1H12 , melanoma adhesion molecule , melanoma-associated antigen A32 , melanoma-associated antigen MUC18 , gicerin , l-gicerin , l-gicerin protein , HEMCAM , melanoma cell adhesion molecule , cell surface glycoprotein MUC18-like

GENE ID SPECIES
4162 Homo sapiens
78967 Rattus norvegicus
84004 Mus musculus
281301 Bos taurus
448832 Gallus gallus
489368 Canis lupus familiaris
733617 Sus scrofa
744688 Pan troglodytes
100071414 Equus caballus
100454353 Pongo abelii
100470323 Ailuropoda melanoleuca
100718224 Cavia porcellus
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