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Mitochondrial Antiviral Signaling Protein Proteins (MAVS)

MAVS encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. Additionally we are shipping MAVS Antibodies (185) and MAVS Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MAVS 9677 Q6PFW1
MAVS 228607 Q8VCF0
Rat MAVS MAVS 311430 Q66HG9
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Top MAVS Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MAVS Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,

Top referenced MAVS Proteins

  1. Human MAVS Protein expressed in Escherichia coli (E. coli) - ABIN1098533 : Seth, Sun, Ea, Chen: Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. in Cell 2005 (PubMed)
    Show all 2 references for ABIN1098533

More Proteins for Mitochondrial Antiviral Signaling Protein (MAVS) Interaction Partners

Pig (Porcine) Mitochondrial Antiviral Signaling Protein (MAVS) interaction partners

  1. The authors determined that porcine reproductive and respiratory syndrome virus 3C protease cleaved MAVS at Glu268.

  2. Real-time quantitative PCR analysis indicated that Tibetan porcine IPS-1 (show ISYNA1 Proteins) mRNA was most abundant in the liver and kidney.

Human Mitochondrial Antiviral Signaling Protein (MAVS) interaction partners

  1. This study identified new functional alterations in antiviral signalling based on MAVS polymorphisms

  2. Data show that the NS3 protein of dengue virus bound to 14-3-3 epsilon protein (14-3-3varepsilon) and prevented translocation of retinoic acid-inducible gene-I protein (RIG-I (show DDX58 Proteins)) to the adaptor MAVS protein and thereby blocked antiviral signaling.

  3. These results demonstrate that poliovirus infection actively suppresses the host type I interferon (show IFNA Proteins) response by blocking activation of IRF-3 (show IRF3 Proteins) and suggests that this is not mediated by cleavage of MDA-5 (show IFIH1 Proteins) or IPS-1.

  4. Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 (show DEFB103A Proteins) suppresses the polyI:C-induced TLR3 (show TLR3 Proteins) response mediated by TICAM1 (TRIF (show TICAM1 Proteins)), while exacerbating the cytoplasmic response through MDA5 (IFIH1 (show IFIH1 Proteins)) and MAVS (IPS1/CARDIF).

  5. Results show MAVS-transmembrane domain is shown to oligomerize in response to changes in the outer mitochondrial lipid membrane properties caused by treatment with mitochondrial reactive oxygen species inducers or by Sendai virus infection.

  6. MARCH5 (show MARCH5 Proteins) binds MAVS only during viral stimulation when MAVS forms aggregates, and these interactions require the RING domain of MARCH5 (show MARCH5 Proteins) and the CARD domain of MAVS.

  7. An autoinhibitory mechanism modulates MAVS activity in unstimulated cells and, on viral infection, individual regions of MAVS are released following MAVS filament formation to activate antiviral signalling cascades.

  8. indicate comparable activation of the IFN response by pex (show PHEX Proteins)- and mito-mitochondrial antiviral-signaling protein in hepatocytes and efficient counteraction of both MAVS species by the HCV nonstructural protein 3 (show HSPB3 Proteins) protease

  9. MAVS50, exposing a degenerate TRAF (show TRAF1 Proteins)-binding motif within its N-terminus, effectively competed with full-length MAVS for recruiting TRAF2 (show TRAF2 Proteins) and TRAF6 (show TRAF6 Proteins)

  10. IPS-1 induces anticancer activity through upregulation of pro-apoptotic gene TRAIL and downregulation of the anti-apoptotic genes BCL2 (show BCL2 Proteins), BIRC3 (show BIRC3 Proteins) and PRKCE (show PRKCE Proteins) via IRF3 (show IRF3 Proteins) and IRF7 (show IRF7 Proteins) in type I interferon (show IFNA Proteins)-dependent and -independent manners.

Mouse (Murine) Mitochondrial Antiviral Signaling Protein (MAVS) interaction partners

  1. Rotavirus infection in macrophages depend on MAVS but not involve the NLRP3 (show NLRP3 Proteins) inflammasome nor JNK (show MAPK8 Proteins) and p38 (show CRK Proteins) signal pathway.

  2. MARCH5 (show MARCH5 Proteins) binds MAVS only during viral stimulation when MAVS forms aggregates, and these interactions require the RING domain of MARCH5 (show MARCH5 Proteins) and the CARD domain of MAVS.

  3. An autoinhibitory mechanism modulates MAVS activity in unstimulated cells and, on viral infection, individual regions of MAVS are released following MAVS filament formation to activate antiviral signalling cascades.

  4. indicate comparable activation of the IFN response by pex (show PHEX Proteins)- and mito-mitochondrial antiviral-signaling protein in hepatocytes and efficient counteraction of both MAVS species by the HCV nonstructural protein 3 (show HSPB3 Proteins) protease

  5. Transmembrane motif T6BM2-mediated TRAF6 (show TRAF6 Proteins) binding is required for MAVS-related antiviral response.

  6. Data show that intracellular adaptor protein Cardif-/- natural killer cells (NK cells) are more apoptotic and less proliferative.

  7. Elucidate the structural mechanism of MAVS polymerization, and explain how an alpha-helical domain uses distinct chemical interactions to form self-perpetuating filaments.

  8. MAVS plays an essential role in host immunity against metapneumovirus infection.

  9. results indicate that Lyn (show LYN Proteins) plays a positive regulatory role in RIG-I (show DDX58 Proteins)-mediated interferon (show IFNA Proteins) expression as a downstream component of IPS-1 (show ISYNA1 Proteins)

  10. In lung epithelial cells, retinoic acid-inducible gene-1 (show RARRES3 Proteins) (RIG-I (show DDX58 Proteins)) was identified as the major RIG-I (show DDX58 Proteins)-like receptor required for RSV-induced protease expression via MAVS.

MAVS Protein Profile

Protein Summary

This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MAVS

  • mitochondrial antiviral signaling protein (MAVS)
  • diphosphoinositol pentakisphosphate kinase 1 (PPIP5K1)
  • mitochondrial antiviral signaling protein (Mavs)
  • cardif protein
  • D430028G21Rik protein
  • HISPPD2A protein
  • hsVIP1 protein
  • IP6K protein
  • IPS-1 protein
  • IPS1 protein
  • VIP1 protein
  • Visa protein

Protein level used designations for MAVS

virus-induced signaling adapter , mitochondrial antiviral-signaling protein , mitochondrial IFN-beta promoter stimulator 1 , IP6 kinase , VIP1 homolog , histidine acid phosphatase domain containing 2A , histidine acid phosphatase domain-containing protein 2A , inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 , inositol pyrophosphate synthase 1 , insP6 and PP-IP5 kinase 1 , CARD adapter inducing interferon beta , CARD adaptor inducing IFN-beta , IFN-B promoter stimulator 1 , interferon beta promoter stimulator protein 1 , putative NF-kappa-B-activating protein 031N , virus-induced signaling adaptor , virus-induced-signaling adapter , IFN-beta promoter stimulator-1 , mitochondrial anti-viral signaling protein , IPS-1 , interferon-beta promoter stimulator protein 1

GENE ID SPECIES
470026 Pan troglodytes
485789 Canis lupus familiaris
717616 Macaca mulatta
100037290 Sus scrofa
9677 Homo sapiens
57506 Homo sapiens
228607 Mus musculus
311430 Rattus norvegicus
618508 Bos taurus
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