Mitochondrial Calcium Uptake 1 Proteins (MICU1)

MICU1 encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. Additionally we are shipping MICU1 Antibodies (33) and MICU1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MICU1 10367 Q9BPX6
MICU1 216001 Q8VCX5
Rat MICU1 MICU1 365567 Q6P6Q9
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Top MICU1 Proteins at antibodies-online.com

Showing 7 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$229.85
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human GST tag   50 μg Log in to see 11 Days
$313.50
Details
Yeast Human His tag   50 μg Log in to see 8 to 11 Days
$341.00
Details

MICU1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

More Proteins for Mitochondrial Calcium Uptake 1 (MICU1) Interaction Partners

Human Mitochondrial Calcium Uptake 1 (MICU1) interaction partners

  1. Results showed that the SNP on EF-hand Ca2 (show CA2 Proteins)+ binding domains of MICU1 gene had no effect in phenotypic characters of bipolar disorder patients

  2. Our experiments provide novel details about how MCU (show MCU Proteins)/EMRE is regulated by MICU1 and an original approach to investigate MCU (show MCU Proteins)/EMRE activation in intact cells.

  3. Data show that ribosomal protein S3 (RPS3 (show RPS3 Proteins)) knockdown decreased mitochondrial calcium uptake 1 protein (MICU1) expression.

  4. Loss of heterozygosity of MICU1 gene on chromosome 10q is associated with pancreatic cancer.

  5. Expression of MICU1 mutants lacking functional Ca2 (show CA2 Proteins)+-binding sites leads to a striking loss of Ca2 (show CA2 Proteins)+ uptake in HEK293 cells.

  6. MICU1 EF hands determine MCU (show MCU Proteins) activity, but not binding.

  7. MICU1 and MICU2 have roles in tuning the mitochondrial Ca2 (show CA2 Proteins)+ uniporter by exerting opposite effects on MCU (show MCU Proteins) activity

  8. Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.

  9. Prolonged MICU1 loss leads to an adaptive increase in matrix Ca(2 (show CA2 Proteins)+) binding, yet cells show impaired oxidative metabolism and sensitization to Ca(2 (show CA2 Proteins)+) overload.

  10. CBARA1 is a marker for undifferentiated human embryonic stem cells that plays a role in maintaining stemness, cell cycle progression, and proliferation.

Mouse (Murine) Mitochondrial Calcium Uptake 1 (MICU1) interaction partners

  1. A MICU1 splice variant confers high sensitivity to the mitochondrial Ca(2 (show CA2 Proteins)+) uptake machinery of skeletal muscle.

  2. MICU1 was downregulated in db/db (show LEPR Proteins) mouse hearts, which contributes to myocardial apoptosis in diabetes. Importantly, the reconstitution of MICU1 in diabetic hearts significantly inhibited the development of diabetic cardiomyopathy, as evidenced by enhanced cardiac function and reduced cardiac hypertrophy and myocardial fibrosis in db/db (show LEPR Proteins) mice.

  3. MICU1 regulation of mitochondrial Ca(2 (show CA2 Proteins)+) uptake dictates survival and liver regeneration.

MICU1 Protein Profile

Protein Summary

This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with MICU1

  • mitochondrial calcium uptake 1 (MICU1)
  • mitochondrial calcium uptake 1 (Micu1)
  • C730016L05Rik protein
  • Calc protein
  • Cbara1 protein
  • EFHA3 protein

Protein level used designations for MICU1

ara CALC , atopy-related autoantigen CALC , calcium uptake protein 1, mitochondrial , calcium-binding atopy-related autoantigen 1 , calcium binding atopy-related autoantigen 1 , calcium-binding atopy-related autoantigen 1 homolog

GENE ID SPECIES
10367 Homo sapiens
216001 Mus musculus
365567 Rattus norvegicus
507899 Bos taurus
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