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MICU1 encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. Additionally we are shipping MICU1 Antibodies (31) and MICU1 Kits (4) and many more products for this protein.
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Results showed that the SNP on EF-hand Ca2 (show CA2 Proteins)+ binding domains of MICU1 gene had no effect in phenotypic characters of bipolar disorder patients
Our experiments provide novel details about how MCU (show MCU Proteins)/EMRE is regulated by MICU1 and an original approach to investigate MCU (show MCU Proteins)/EMRE activation in intact cells.
Data show that ribosomal protein S3 (RPS3 (show RPS3 Proteins)) knockdown decreased mitochondrial calcium uptake 1 protein (MICU1) expression.
Loss of heterozygosity of MICU1 gene on chromosome 10q is associated with pancreatic cancer.
Expression of MICU1 mutants lacking functional Ca2 (show CA2 Proteins)+-binding sites leads to a striking loss of Ca2 (show CA2 Proteins)+ uptake in HEK293 cells.
MICU1 EF hands determine MCU (show MCU Proteins) activity, but not binding.
MICU1 and MICU2 have roles in tuning the mitochondrial Ca2 (show CA2 Proteins)+ uniporter by exerting opposite effects on MCU (show MCU Proteins) activity
Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.
Prolonged MICU1 loss leads to an adaptive increase in matrix Ca(2 (show CA2 Proteins)+) binding, yet cells show impaired oxidative metabolism and sensitization to Ca(2 (show CA2 Proteins)+) overload.
CBARA1 is a marker for undifferentiated human embryonic stem cells that plays a role in maintaining stemness, cell cycle progression, and proliferation.
MICU1 regulation of mitochondrial Ca(2 (show CA2 Proteins)+) uptake dictates survival and liver regeneration.
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described.
, atopy-related autoantigen CALC
, calcium uptake protein 1, mitochondrial
, calcium-binding atopy-related autoantigen 1
, calcium binding atopy-related autoantigen 1
, calcium-binding atopy-related autoantigen 1 homolog