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MICU1 encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. Additionally we are shipping MICU1 Antibodies (33) and MICU1 Kits (4) and many more products for this protein.
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Results showed that the SNP on EF-hand Ca2 (show CA2 Proteins)+ binding domains of MICU1 gene had no effect in phenotypic characters of bipolar disorder patients
Our experiments provide novel details about how MCU (show MCU Proteins)/EMRE is regulated by MICU1 and an original approach to investigate MCU (show MCU Proteins)/EMRE activation in intact cells.
Data show that ribosomal protein S3 (RPS3 (show RPS3 Proteins)) knockdown decreased mitochondrial calcium uptake 1 protein (MICU1) expression.
Loss of heterozygosity of MICU1 gene on chromosome 10q is associated with pancreatic cancer.
Expression of MICU1 mutants lacking functional Ca2 (show CA2 Proteins)+-binding sites leads to a striking loss of Ca2 (show CA2 Proteins)+ uptake in HEK293 cells.
MICU1 EF hands determine MCU (show MCU Proteins) activity, but not binding.
MICU1 and MICU2 have roles in tuning the mitochondrial Ca2 (show CA2 Proteins)+ uniporter by exerting opposite effects on MCU (show MCU Proteins) activity
Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.
Prolonged MICU1 loss leads to an adaptive increase in matrix Ca(2 (show CA2 Proteins)+) binding, yet cells show impaired oxidative metabolism and sensitization to Ca(2 (show CA2 Proteins)+) overload.
CBARA1 is a marker for undifferentiated human embryonic stem cells that plays a role in maintaining stemness, cell cycle progression, and proliferation.
A MICU1 splice variant confers high sensitivity to the mitochondrial Ca(2 (show CA2 Proteins)+) uptake machinery of skeletal muscle.
MICU1 was downregulated in db/db (show LEPR Proteins) mouse hearts, which contributes to myocardial apoptosis in diabetes. Importantly, the reconstitution of MICU1 in diabetic hearts significantly inhibited the development of diabetic cardiomyopathy, as evidenced by enhanced cardiac function and reduced cardiac hypertrophy and myocardial fibrosis in db/db (show LEPR Proteins) mice.
MICU1 regulation of mitochondrial Ca(2 (show CA2 Proteins)+) uptake dictates survival and liver regeneration.
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described.
, atopy-related autoantigen CALC
, calcium uptake protein 1, mitochondrial
, calcium-binding atopy-related autoantigen 1
, calcium binding atopy-related autoantigen 1
, calcium-binding atopy-related autoantigen 1 homolog