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MICU1 Products

(Mitochondrial Calcium Uptake 1 (MICU1))
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013].

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Featured MICU1 Categories

MICU1 Antibodies

High quality antibodies with extensive validation data.

MICU1 ELISA Kits

Reliable ELISA kits for a wide range of species.

MICU1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MICU1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p), IF
Validations
  • (5)
Cat. No. ABIN7206382
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p), IF
Validations
  • (3)
Cat. No. ABIN7250269
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7178517
Quantity 100 μg
Datasheet Datasheet

Recommended MICU1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968632
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1124747
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1124748
Quantity 96 tests
Datasheet Datasheet

Recommended MICU1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348155
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348154
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093899
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our MICU1 products

Niemann, Zehm, Waterstradt, Tiedge, Baltrusch: "Cytosolic and mitochondrial Ca2+ concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation." in: Cell calcium, Vol. 82, pp. 102055, (2019) (PubMed).

Ji, Liu, Jing, Huang, Zhao, Cao, Li, Yin, Xing, Li: "MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca(2+)-Dependent Antioxidant Response." in: Diabetes, Vol. 66, Issue 6, pp. 1586-1600, (2017) (PubMed).

Liu, Liu, Holmström, Menazza, Parks, Fergusson, Yu, Springer, Halsey, Liu, Murphy, Finkel: "MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload." in: Cell reports, Vol. 16, Issue 6, pp. 1561-73, (2016) (PubMed).

Wang, Xie, Zhou, Yao, Zhu, Huang, Zhang, Wei, Xie, Zhou, Zheng: "Mitofusin-2 triggers mitochondria Ca2+ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells." in: Cancer letters, Vol. 358, Issue 1, pp. 47-58, (2015) (PubMed).

Lee, Min, Kim, Song, Lim, Kim, Shin, Kang, Kang, Youn, Lee, An, Park, Lim, Kim, Kim, Park, Kim, Wang, Kim, Eom: "Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter." in: EMBO reports, Vol. 16, Issue 10, pp. 1318-33, (2015) (PubMed).

Logan, Szabadkai, Sharpe, Parry, Torelli, Childs, Kriek, Phadke, Johnson, Roberts, Bonthron, Pysden, Whyte, Munteanu, Foley, Wheway, Szymanska, Natarajan, Abdelhamed, Morgan, Roper, Santen, Niks et al.: "Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling. ..." in: Nature genetics, Vol. 46, Issue 2, pp. 188-93, (2014) (PubMed).

Lam, Martell, Kamer, Deerinck, Ellisman, Mootha, Ting: "Directed evolution of APEX2 for electron microscopy and proximity labeling." in: Nature methods, Vol. 12, Issue 1, pp. 51-4, (2014) (PubMed).

de la Fuente, Matesanz-Isabel, Fonteriz, Montero, Alvarez: "Dynamics of mitochondrial Ca2+ uptake in MICU1-knockdown cells." in: The Biochemical journal, Vol. 458, Issue 1, pp. 33-40, (2014) (PubMed).

Synonyms and alternative names related to MICU1

mitochondrial calcium uptake 1 (MICU1), mitochondrial calcium uptake 1 (Micu1), C730016L05Rik, CALC, Calc, CBARA1, Cbara1, EFHA3

Protein level used designations for MICU1

  • ara CALC
  • atopy-related autoantigen CALC
  • calcium uptake protein 1, mitochondrial
  • calcium-binding atopy-related autoantigen 1
  • calcium binding atopy-related autoantigen 1
  • calcium-binding atopy-related autoantigen 1 homolog
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