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interacts with PPARalpha and with various nuclear hormone receptors [RGD, Feb 2006].. Additionally we are shipping Mitochondrial Trans-2-Enoyl-CoA Reductase Antibodies (34) and many more products for this protein.
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Human MECR Protein expressed in Escherichia coli (E. coli) - ABIN667794
Chen, Pudas, Sharma, Smart, Juffer, Hiltunen, Wierenga, Haapalainen: Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties. in Journal of molecular biology 2008
Show all 2 references for ABIN667794
overexpression of MECR, the last step in the mitochondrial fatty acid synthesis (mtFASII) pathway, causes modulation of gene expression through the PPAR (show PPARA Proteins) pathway.
The crystal structure of this dimeric enzyme (at 2.4 A resolution) suggests that the binding site for the recognition helix of the acyl carrier protein is in a groove between the two adjacent monomers.
The results showed a ventricular dilatation behind impaired heart function upon Mecr overexpression, concurrent with appearance of dysmorphic mitochondria
interacts with PPARalpha and with various nuclear hormone receptors
, homolog of yeast 2-enoyl thioester reductase
, mitochondrial 2-enoyl thioester reductase
, nuclear receptor binding factor 1
, nuclear receptor-binding factor 1
, trans-2-enoyl-CoA reductase, mitochondrial