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Monoglyceride Lipase Proteins (MGLL)

MGLL encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. Additionally we are shipping MGLL Antibodies (126) and MGLL Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MGLL 11343 Q99685
MGLL 23945 O35678
MGLL 29254 Q8R431
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Top MGLL Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,806.83
Details
Yeast Mouse His tag   1 mg Log in to see 56 to 66 Days
$2,806.83
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$5,769.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$467.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Human Un-conjugated   2 μg Log in to see 6 Days
$168.54
Details

MGLL Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine) ,

Rat (Rattus)

Top referenced MGLL Proteins

  1. Human MGLL Protein expressed in Escherichia coli (E. coli) - ABIN667833 : Nomura, Long, Niessen, Hoover, Ng, Cravatt: Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. in Cell 2010 (PubMed)
    Show all 2 references for ABIN667833

  2. Human MGLL Protein expressed in Wheat germ - ABIN1310880 : Bolen, Naren, Yarlagadda, Beranova-Giorgianni, Chen, Norman, Baker, Rowland, Best, Sano, Tsukahara, Liliom, Igarashi, Tigyi: The phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulation. in Journal of lipid research 2011 (PubMed)

More Proteins for Monoglyceride Lipase (MGLL) Interaction Partners

Human Monoglyceride Lipase (MGLL) interaction partners

  1. Monoacylglycerol lipase sulfenylation might act as an intrinsic neuroprotective mechanism by potentiating 2-AG signaling at CB1 (show CNR1 Proteins) receptors.

  2. The study identified monoacylglycerol lipase as a YAP (show YAP1 Proteins) transcriptional target and an inhibitor of anchorage-dependent cell growth.

  3. Molecular dynamics and nudged elastic band simulations were used to explore the conformational transition pathway of the helix alpha4 of human monoacylglycerol lipase.

  4. role of monoacylglycerol lipase (MAGL) in the cancer progress

  5. Our findings establish that MAGL promotes metastases in nasopharyngeal carcinoma

  6. In subcutaneous adipose tissue, DAGL-a mRNA was upregulated and fatty acid amide hydrolase (FAAH (show FAAH Proteins)) and monoacylglycerol lipase (MAGL) mRNAs were down-regulated in obese subjects, but the diets had no influence.

  7. In obese humans, FAAH (show FAAH Proteins) or MGL (show CLEC10A Proteins) activity in adipocytes is not affected by diabetes, dyslipidaemia or other markers of metabolic dysfunction.

  8. Mutation of Cys242 was also found to impair inhibition of monoacylglycerol lipase.

  9. MGL (show CLEC10A Proteins) interaction with a phospholipid membrane bilayer induces regional changes in the enzyme's conformation that favor its recruiting lipophilic substrate from membrane stores to the active site resulting in enhanced MGL (show CLEC10A Proteins) catalytic activity.

  10. Data indicate that N,N-dimethyl-5-(4-phenoxyphenyl)-2H-tetrazole-2-carboxamide inhibited monoacylglycerol lipase (MAGL) with IC50 0.028 muM.

Mouse (Murine) Monoglyceride Lipase (MGLL) interaction partners

  1. MGL (show CLEC10A Proteins) in astrocytes is an important regulator of 2-arachidonoylglyerol levels, arachidonic acid availability, and neuroinflammation.

  2. Genetic and pharmacological ablation of Magl attenuated centrally-mediated fever response.

  3. the results indicate that global MGL (show CLEC10A Proteins) deletion leads to systemic changes that produce a leaner (show CACNA1A Proteins) phenotype and an improved serum metabolic profile.

  4. This study showed that Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CBR (show CBR1 Proteins) signaling and anxiety-like behavior.

  5. Suggest that organophosphate agents induce plasma hypertriglyceridemia in mouse through single or dual inhibition of FAAH (show FAAH Proteins) or/and MAGL, apparently leading to overstimulation of cannabinoid signal regulating energy metabolism.

  6. Inactivation of Monoacylglycerol lipase robustly suppressed production and accumulation of beta-amyloid (Abeta (show APP Proteins)) associated with reduced expression of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1 (show BACE Proteins)) in a mouse model of Alzheimer's disease.

  7. Data indicate that nerve growth factor (NGF) controls monoacylglycerol lipase (MGL) degradation in vitro and in vivo.

  8. The results therefore suggest a role for intestinal MGL (show CLEC10A Proteins) in whole body energy balance via regulation of food intake as well as metabolic rate.

  9. MGL (show CLEC10A Proteins) regulates 2-arachidonoylglycerol signaling rather broadly within a certain range of neural tissue, although MGL (show CLEC10A Proteins) expression is heterogeneous and limited to a subset of nerve terminals and astrocytes.

  10. results indicate that genetic deletion of MAGL causes profound changes in eCB signaling, long-term synaptic plasticity, and learning behavior.

MGLL Protein Profile

Protein Summary

This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with Monoglyceride Lipase Proteins (MGLL)

  • monoglyceride lipase (mgll)
  • monoglyceride lipase (MGLL)
  • monoglyceride lipase (13L)
  • monoglyceride lipase (YMTVg13L)
  • Monoglyceride lipase (EHI_044210)
  • Monoglyceride lipase (EHI_045330)
  • monoglyceride lipase (TATV_DAH68_039)
  • Monoglyceride lipase (mgll)
  • monoglyceride lipase (Mgll)
  • AA589436 protein
  • cb909 protein
  • HU-K5 protein
  • HUK5 protein
  • Magl protein
  • MGC84195 protein
  • Mgl protein
  • mgll protein
  • wu:fc66g01 protein
  • zgc:56561 protein

Protein level used designations for Monoglyceride Lipase Proteins (MGLL)

monoglyceride lipase , Monoglyceride lipase , lysophospholipase homolog , monoacylglycerol lipase , MGL

GENE ID SPECIES
378960 Danio rerio
416024 Gallus gallus
447764 Xenopus laevis
739167 Pan troglodytes
918715 Yaba-like disease virus
2943660 Yaba monkey tumor virus
3406682 Entamoeba histolytica HM-1:IMSS
3411603 Entamoeba histolytica HM-1:IMSS
4238603 Taterapox virus
5656658 Tanapox virus
100127203 Xenopus (Silurana) tropicalis
100194972 Salmo salar
11343 Homo sapiens
476511 Canis lupus familiaris
100233193 Sus scrofa
505290 Bos taurus
23945 Mus musculus
29254 Rattus norvegicus
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