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Mucosal Vascular Addressin Cell Adhesion Molecule 1 Proteins (MADCAM1)

The protein encoded by MADCAM1 is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. Additionally we are shipping Mucosal Vascular Addressin Cell Adhesion Molecule 1 Antibodies (205) and Mucosal Vascular Addressin Cell Adhesion Molecule 1 Kits (37) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MADCAM1 17123  
MADCAM1 8174 Q13477
MADCAM1 54266 O70540
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Top Mucosal Vascular Addressin Cell Adhesion Molecule 1 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,902.17
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$936.27
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MADCAM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , ,
,
Rat (Rattus)

More Proteins for Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) Interaction Partners

Mouse (Murine) Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) interaction partners

  1. beta7 integrin, when expressed by hematopoietic stem cells (HSC (show FUT1 Proteins)), interacted with its endothelial ligand MAdCAM-1 in the Bone marrow microenvironment, thereby promoting HSC (show FUT1 Proteins) homing and engraftment.

  2. Nkx2-3 deficiency reprograms the endothelial addressin preference for lymphocyte homing in Peyer's patches.

  3. findings indicate that alpha4beta7*IgG can be used as a probe for functional MAdCAM-1 expressed on HEVs in GALT (show GALT Proteins) and could potentially serve as an anti-inflammatory drug inhibiting GALT (show GALT Proteins)-specific lymphocyte migration

  4. ectopic expression of MAdCAM-1 at the BBB does not increase alpha4beta7-integrin-mediated immune cell trafficking into the CNS during MOG (show MOG Proteins)(aa35-55)-induced experimental autoimmune encephalomyelitis

  5. Observed a significant decrease in expression of ICAM-1 (show ICAM1 Proteins) and MAdCAM-1 mRNA/protein in lactobacillus plantarum treated colitis.

  6. results suggest that AT1R (show AGTRAP Proteins) regulates the expression of MAdCAM-1 under colonic inflammatory conditions through regulation of the translocation of NF-kappaB (show NFKB1 Proteins) into the nucleus

  7. Lymphocyte binding to MAdCAM-1 via alpha4beta7 integrin activates a signal transduction pathway involving tyrosine phosphorylation of paxillin (show PXN Proteins) and p105(Cas-L (show NEDD9 Proteins))

  8. Mucosal addressin cell adhesion molecule 1 plays an unexpected role in the development of mouse guard hair.

  9. spatial heterogeneity of MAdCAM-1 and VCAM-1 (show VCAM1 Proteins) activation following TNF-alpha (show TNF Proteins) challenge may promote specific T lymphocyte recruitment in the inflamed colonic mucosa

  10. Increased expression of mucosal addressin cell adhesion molecule-1 in gastritis induced by Helicobacter pylori

Human Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) interaction partners

  1. Doxo-induced apoptosis has a role in inhibiting hepatocellular carcinoma by targeting Madcam1 and AKT (show AKT1 Proteins) and blocking protein translation initiation

  2. MADCAM1 is up-regulated in liver cirrhosis with expression on peribiliary vascular plexus and lymphoid aggregates

  3. Domain 1 of mucosal addressin cell adhesion molecule (show MCAM Proteins) has an I1-set fold and a flexible integrin-binding loop.

  4. Findings suggest that the inactive alpha4beta7 and alpha4beta7 activated by different stimuli have distinct conformations with different structural requirements for MAdCAM-1 binding.

  5. Ca2 (show CA2 Proteins)+ is essential for cell tethering in flow and rolling interactions through alpha 4 integrins with MAdCAM-1 as substrate; Mg2 (show MUC7 Proteins)+ promotes firm adhesion of cells on MAdCAM-1 but with much lower tethering efficiency in shear flow.

  6. A crystal structure for the two extracellular amino-terminal domains of human MAdCAM-1

  7. more extensive expression of MAdCAM-1 in Crohn's disease (CrD (show CRX Proteins)), than in ulcerative colitis, which could contribute not only to mucosal inflammation, but also to transmural inflammation in CrD (show CRX Proteins).

  8. MAdCAM-1/integrin alpha4beta7 homing system may participate in gastric inflammation in response to H pylori-infection and contributes to MALT formation, typically leading to the development of nodular gastritis.

  9. PI3-K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) is involved in the gut (show GUSB Proteins)-specific differentiation of human intestinal microvascular endothelial cells, which results in expression of the mucosal addressin MAdCAM-1

  10. Immobilized CCL25 (show CCL25 Proteins) and CCL28 (show ENC1 Proteins) are both able to trigger integrin alpha(4 (show ITGA4 Proteins))beta(7)-dependent lymphocyte arrest on MAdCAM-1 under shear flow.

Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) Protein Profile

Protein Summary

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.

Gene names and symbols associated with MADCAM1

  • mucosal vascular addressin cell adhesion molecule 1 (MADCAM1)
  • mucosal vascular addressin cell adhesion molecule 1 (Madcam1)
  • mucosal vascular addressin cell adhesion molecule 1 (MADCAM-1)
  • AV211525 protein
  • MACAM1 protein
  • MADCAM1 protein

Protein level used designations for MADCAM1

mucosal vascular addressin cell adhesion molecule 1 , MAdCAM-1 , mMAdCAM-1 , mucosal addressin cell adhesion molecule 1 , hMAdCAM-1 , mucosal addressin cell adhesion molecule-1 , rMAdCAM-1 , mucosal addressin cellular adhesion molecule-1

GENE ID SPECIES
789849 Bos taurus
17123 Mus musculus
8174 Homo sapiens
54266 Rattus norvegicus
100722478 Cavia porcellus
492312 Sus scrofa
485103 Canis lupus familiaris
527275 Bos taurus
100858236 Gallus gallus
654333 Ovis aries
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