MADCAM1 Protein (Biotin,Fc-Avi Tag)

Catalog No. ABIN7316926

Product Details

Target: MADCAM1 (Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This MADCAM1 protein is labelled with Biotin,Fc-Avi Tag.

Purpose: Biotinylated Human MAdCAM-1 Protein, Fc,Avitag™ (MALS verified)

Sequence: Gln 19- Gln 333

Characteristics: Biotinylated Human MAdCAM-1, Fc Tag is expressed from human 293 cells (HEK293). It contains AA Gln 19- Gln 333 (Accession # Q4PKD0-1).

Purity: 95,00 %

Endotoxin Level: 1.0 EU per μg

Grade: MALS verified

Application Details

Comment:

This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 63 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -20 °C

Storage Comment: -20°C

Target Details

Target: MADCAM1 (Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1))

Alternative Name: MAdCAM-1 (MADCAM1 Products)

Synonyms: MACAM1 Protein, AV211525 Protein, mucosal vascular addressin cell adhesion molecule 1 Protein, MADCAM1 Protein, Madcam1 Protein

Background: Synonyms:MAdCAM-1,Mucosal vascular addressin cell adhesion molecule 1 transcript variant 1,Description:The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) takes a key role in the endothelial adhesion and migration of lymphocytes to sites of inflammation in inflammatory disease. In vitro and in vivo data indicate that blockade of the adhesion molecule mucosal address in cell adhesion molecule (MAdCAM) pathway decreases leukocyte homing to the gut by inhibiting the interaction between MAdCAM and its ligand the α4β7 integrin expressed on lymphocytes.

Molecular Weight: 63 kDa