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Myosin Phosphatase, Target Subunit 1 (PPP1R12A) ELISA Kits

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Additionally we are shipping PPP1R12A Antibodies (94) and PPP1R12A Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PPP1R12A 17931 Q9DBR7
PPP1R12A 4659 O14974
PPP1R12A 116670 Q10728
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Top PPP1R12A ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human
96 Tests Log in to see 2 to 3 Days
$480.00
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More ELISA Kits for PPP1R12A Interaction Partners

Mouse (Murine) Myosin Phosphatase, Target Subunit 1 (PPP1R12A) interaction partners

  1. phosphorylation of MYPT1 T694, but not T852, mediates force maintenance in bladder smooth muscle.

  2. Constitutive phosphorylation of myosin phosphatase targeting subunit-1 in smooth muscle

  3. Maturation of mesenteric artery smooth muscle involves TRA2beta (show TRA2B ELISA Kits) mediated Mypt1 exon 24 splicing.

  4. The role of MYPT1 in vascular smooth muscle was investigated in adult MYPT1 smooth muscle specific knock-out mice. MYPT1 deletion enhanced phosphorylation of myosin regulatory light chain and contractile force in isolated mesenteric arteries.

  5. MYPT1 is not essential for smooth muscle function in mice but regulates the Ca(2 (show CA2 ELISA Kits)+) sensitivity of force development and contributes to intestinal phasic contractile phenotype.

  6. Tra2beta (show TRA2B ELISA Kits), by regulating the splicing of Mypt1 E23, sets the sensitivity of smooth muscle to cGMP-mediated relaxation.

  7. Organ-specific mechanisms involving MYPT1, M-RIP (show MPRIP ELISA Kits), and CPI-17 (show PPP1R14A ELISA Kits) are critical to regulating basal LC20 (show MYL9 ELISA Kits) phosphorylation in gastrointestinal smooth muscles.

  8. Findings define a new conserved pathway in which sexual development and pregnancy mediate smooth and striated (show NSDHL ELISA Kits) muscle adaptations through SMTNL1 and MYPT1.

  9. a reduction in the protein level of MYPT1 (LZ+) is involved in nitrate tolerance; this may result in part from a proteasome-dependent degradation of MYPT1 (LZ+)

  10. Stable transfection of HEK 293 cells with GFP-MYPT1 was obtained. MYPT1 and its N-terminal mutants bound to retinoblastoma protein (Rb), raising the possibility that Rb is implicated in the effects caused by overexpression of MYPT1.

Human Myosin Phosphatase, Target Subunit 1 (PPP1R12A) interaction partners

  1. These results indicate that PPP1R12A indeed plays a role in skeletal muscle insulin (show INS ELISA Kits) signaling

  2. the relative expression of LZ+/LZ (show LYZ ELISA Kits)- MYPT1 isoforms, in part, defines the vascular response to NO and NO based vasodilators, and therefore, plays a role in the regulation of vascular tone in both health and disease

  3. Expression of NUAK1 is controlled by cyclin-dependent kinase, PLK1, and the SCFbetaTrCP (Skp, Cullin and F-boxbetaTrCP) E3 ubiquitin ligase complex.

  4. distinct roles of two inhibitory phosphorylation sites of MYPT1

  5. in apoptotic cells, the myosin-binding domain of myosin phosphatase targeting subunit 1 is cleaved by caspase-3, and the cleaved MYPT1 is strongly phosphorylated at Thr-696 and Thr-853, phosphorylation of which is known to inhibit myosin II binding

  6. results suggested that during atherosclerosis progression oxidative stress mediates the downregulation of MYPT1, which may inhibit smooth muscle cell migration and contribute to the aberrant contractility

  7. Calcineurin (show PPP3CA ELISA Kits) may modulate the phosphorylation level of MLC20 (show MYL12B ELISA Kits) by influencing the phosphorylation state of MYPT1 to regulate endothelial barrier function.

  8. Mypt1 colocalizes outside the nucleus with Nkx2.5 in a manner dependent on Wnt signaling and Rho-associated protein kinase.

  9. These findings provide evidence for the involvement of a particular PP1 (show PPA1 ELISA Kits) complex, PPP1R12A/PP1cdelta, in insulin (show INS ELISA Kits) signaling.

  10. Site-specific phosphorylation of protein phosphatase 1 regulatory subunit 12A stimulated or suppressed by insulin (show INS ELISA Kits).

PPP1R12A Antigen Profile

Antigen Summary

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PPP1R12A

  • protein phosphatase 1, regulatory (inhibitor) subunit 12A (Ppp1r12a) antibody
  • protein phosphatase 1, regulatory subunit 12A (PPP1R12A) antibody
  • protein phosphatase 1, regulatory subunit 12A (Ppp1r12a) antibody
  • 1200015F06Rik antibody
  • 5730577I22Rik antibody
  • AA792106 antibody
  • AV099298 antibody
  • D10Ertd625e antibody
  • M110 antibody
  • M130 antibody
  • MBS antibody
  • MBSP antibody
  • MYPT1 antibody

Protein level used designations for PPP1R12A

myosin phosphatase target subunit 1 , myosin phosphatase, target subunit 1 , myosin phosphatase-targeting subunit 1 , protein phosphatase 1 regulatory subunit 12A , myosin binding subunit , protein phosphatase 1, regulatory (inhibitor) subunit 12A , protein phosphatase myosin-binding subunit , PP-1M , protein phosphatase subunit 1M , serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110 , smooth muscle myosin phosphatase myosin-binding subunit , 130 kDa myosin-binding subunit of smooth muscle myosin phophatase , 130 kDa myosin-binding subunit of smooth muscle myosin phosphatase , 133kDa myosin-binding subunit of smooth muscle myosin phosphatase (M133) , PP1M subunit M110

GENE ID SPECIES
17931 Mus musculus
4659 Homo sapiens
116670 Rattus norvegicus
396020 Gallus gallus
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