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NQO1 is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. Additionally we are shipping NQO1 Kits (20) and NQO1 Proteins (15) and many more products for this protein.
Showing 10 out of 200 products:
Dog (Canine) Monoclonal NQO1 Primary Antibody for FACS, ICC - ABIN152344
Siegel, Franklin, Ross: Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors. in Clinical cancer research : an official journal of the American Association for Cancer Research 1998
Show all 22 references for ABIN152344
Dog (Canine) Polyclonal NQO1 Primary Antibody for EIA, WB - ABIN782904
Tanaka, Aleksunes, Cui, Klaassen: ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling. in Toxicological sciences : an official journal of the Society of Toxicology 2009
Show all 10 references for ABIN782904
Human Polyclonal NQO1 Primary Antibody for ELISA, WB - ABIN184714
Asher, Lotem, Kama, Sachs, Shaul: NQO1 stabilizes p53 through a distinct pathway. in Proceedings of the National Academy of Sciences of the United States of America 2002
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Dog (Canine) Polyclonal NQO1 Primary Antibody for ELISA, WB - ABIN249473
Singh, Zahid, Saeed, Gaikwad, Meza, Cavalieri, Rogan, Chakravarti: NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells. in The Journal of steroid biochemistry and molecular biology 2009
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Human Polyclonal NQO1 Primary Antibody for IF (p), IHC (p) - ABIN678428
Wang, Peng, Wei, Wei, Wang, Ma, Yao, Fu, Zu: Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway. in Biochimica et biophysica acta 2015
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Human Monoclonal NQO1 Primary Antibody for FACS, IHC - ABIN969319
Kansanen, Jyrkkänen, Volger, Leinonen, Kivelä, Häkkinen, Woodcock, Schopfer, Horrevoets, Ylä-Herttuala, Freeman, Levonen: Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid. in The Journal of biological chemistry 2009
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Human Monoclonal NQO1 Primary Antibody for FACS, ELISA - ABIN969320
Douglas, Lim, Porter, West, Pink, Ge, Wylie, Tibbits, Biggs, Curtis, Palombella, Adams, Fritz, Normant: The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo. in Molecular cancer therapeutics 2009
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Human Polyclonal NQO1 Primary Antibody for WB - ABIN1686087
La Sala, Pujadas, De Nigris, Canivell, Novials, Genovese, Ceriello: Oscillating glucose and constant high glucose induce endoglin expression in endothelial cells: the role of oxidative stress. in Acta diabetologica 2014
Mouse (Murine) Monoclonal NQO1 Primary Antibody for ICC, FACS - ABIN1042634
Siegel, Ross: Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues. in Free radical biology & medicine 2001
significant structural and functional changes incurred by NQO1 antioxidant protein (show PRDX3 Antibodies) as a result of alteration in its nucleotide, are reported.
Study provides a comprehensive picture of the structural and dynamic consequences of NQO1 polymorphisms, linking changes in protein dynamics with impaired NQO1 function and FAD (show BRCA2 Antibodies) binding, particularly for p.P187S, leading to increased cancer susceptibility.
Polymorphism of the NQO1 Gene is associated with Breast Cancer.
patients who carry the wild type genotype or only one polymorphism for either NQO1 or GSTP1 (show GSTP1 Antibodies) gene have possibly a better clinical outcome after the natalizumab therapy.
The association of colorectal adenomas with the rs6983267 variant at 8q24 was considered as 'highly credible', the 'less credible' associations were identified with a further four variants of four independent genes: MTHFR (show MTHFR Antibodies) c.677C>T p.A222V(rs1801133), TP53 (show TP53 Antibodies) c.215C>G p.R72P (rs1042522), NQO1 c.559C>T p.P187S (rs1800566), and NAT1 (show EIF4G2 Antibodies) alleles imputed as fast acetylator genotypes. [meta-analysis]
Results show that NQO1 is up-regulated in non-small cell lung neoplasm which correlates with poor survival.
Meta-analysis. our results showed that NQO1 C609T polymorphism increases the risk of Alzheimer disease in Chinese populations.
The present study revealed that NQO1 CT, TT and CT+TT genotypes may be associated with clinical outcome and risk of developing NSCLC in the Indian population.
Flavin reductase (show BLVRB Antibodies) and calreticulin (show CALR Antibodies) play key roles in the development of pemetrexed-associated resistance in lung adenocarcinoma cells.
NQO1 was significantly increased in all of the diseased livers including peri (show PLIN1 Antibodies)-hepatocellular carcinoma tissues.
NQO1 plays a critical role in protection against energy depletion in acetaminophen-induced liver injury, and is associated with improvement of mitochondrial dysfunction
The present results demonstrate that exacerbated cisplatin-induced nephrotoxicity under the NQO1-knockout condition was accompanied by the reduced expression of MRN complex proteins, ATM (show ATM Antibodies), PARP1 (show PARP1 Antibodies), and Sirt1 (show SIRT1 Antibodies).
Taken together, these data suggest that EEEC attenuates oxidative stress by activating Nrf2 (show NFE2L2 Antibodies)-mediated HO-1 (show HMOX1 Antibodies) and inducing NQO-1 via the activation of MAPK (show MAPK1 Antibodies) signaling pathways.
We defined the basal and butylated hydroxyanisole induced expression patterns of Nqo1, AKR1B8, and Ho-1 (show HMOX1 Antibodies) in the liver and small intestine of C57BL/6 mice.
The colons of NQO1-KO mice also showed high levels of reactive oxygen species (ROS (show ROS1 Antibodies)) and histone deacetylase (HDAC (show HDAC1 Antibodies)) activity, which are known to affect transcriptional regulation.
the induction of cellular NAD(+) levels using beta-lapachone (beta-Lap), whose intracellular target is NQO1, prevents the toxic effects of cisplatin through the regulation of PARP-1 (show PARP1 Antibodies) and SIRT1 (show SIRT1 Antibodies) activity.
Nqo1 expression is protective against renal ischemia/reperfusion injury in mice.
results indicate that AAI can increase its own metabolic activation by inducing NQO1, thereby enhancing its own genotoxic potential.
PCB (show PC Antibodies)-77 induced reductions in insulin (show INS Antibodies) signaling in adipose tissue were also abolished by Resveratrol, which increased NQO1 expression.
NQO1 does not play a major role in the production of vitamin K hydroquinone and supports the existence of multiple vitamin K reduction pathways.
The obtained data convincingly showed that porcine NADPH-d cells may produce nitric oxide.
Immunoreactivity of eNOS (show NOS3 Antibodies) was similar to NADPH-d staining. Clear iNOS (show NOS2 Antibodies) immunoreactivity was detected in the luminal epithelium, endometrial stroma and individual endometrial glands.
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
NAD(P)H dehydrogenase [quinone] 1
, NAD(P)H menadione oxidoreductase 1, dioxin-inducible
, NAD(P)H dehydrogenase, quinone 1
, NAD(P)H:quinone oxidoreductase 1
, menadione reductase
, phylloquinone reductase
, quinone reductase 1
, nad(p)h dehydrogenase (quinone) 1
, NAD(P)H:Quinone acceptor oxidoreductase type 1
, NAD(P)H:menadione oxidoreductase 1
, NAD(P)H:quinone oxireductase
, diaphorase (NADH/NADPH) (cytochrome b-5 reductase)
, dioxin-inducible 1
, Diaphorase (NADH/NADPH)
, NAD(P)H:menadione oxidoreductase
, NAD(P)H dehydrogenase (quinone)
, NAD(P)H menadione oxidoreductase 1, dioxin inducible
, diaphorase 4 (NADH/NADPH)
, nicotinamide adenine dinucleotide phosphate diaphorase
, diaphorase 4
, NAD(P)H: quinone oxidoreductase 1