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NK2 Homeobox 1 Proteins (NKX2-1)

NKX2-1 encodes a protein initially identified as a thyroid-specific transcription factor. Additionally we are shipping NK2 Homeobox 1 Antibodies (202) and NK2 Homeobox 1 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NKX2-1 7080 P43699
NKX2-1 21869 P50220
NKX2-1 25628  
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Top NK2 Homeobox 1 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Guinea Pig His tag   1 mg Log in to see 56 to 66 Days
$2,212.83
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$3,017.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,019.50
Details

NKX2-1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for NK2 Homeobox 1 (NKX2-1) Interaction Partners

Human NK2 Homeobox 1 (NKX2-1) interaction partners

  1. In adenocarcinomas from extrahepatic biliary tract, there was no correlation between TTF-1 expression and the clinicopathological characteristics.

  2. Suggest TTF-1 is a reliable marker in non-small cell lung carcinoma and can be used in differential diagnosis.

  3. EGFR (show EGFR Proteins) knockdown led to upregulation of NKX2-1, suggesting a negative feedback loop. combined knockdown of NKX2-1 and EGFR (show EGFR Proteins) in NCI-H1819 lung cancer cells reduced cell proliferation more than knockdown of either alone.

  4. TTF-1 had no prognostic value concerning OS, but may serve as a predictor for response to first line chemotherapy in small cell lung cancer.

  5. Authors suggest that NKX2-1 as a tumour suppressor or a tumour promoter in lung adenocarcinoma progression is dependent on p53 (show TP53 Proteins) status.

  6. TTF-1 is considered to be an excellent marker of pituicytes, specialized glia of the neurohypophysis.

  7. Aberrant expression of mir (show MLXIP Proteins)-365/TTF-1 may be involved in the tumor development in patients with non-small cell lung carcinoma.

  8. Different staining patterns can be seen with CK5 (show KRT5 Proteins)/6 and p63 (show RPE65 Proteins); however, if they are used together with TTF-1 they can be used in subtyping lung neoplasms.

  9. No TTF1 or EAP1 (show DAXX Proteins) germline mutations were associated with central pubertal disorders. TTF1 and EAP1 (show DAXX Proteins) may affect puberty by changing expression in response to other members of puberty-associated gene networks

  10. Loss of TTF-1 is associated with low response to chemotherapy in non-small-cell lung cancer.

Mouse (Murine) NK2 Homeobox 1 (NKX2-1) interaction partners

  1. Identify regulatory link between Nkx2-1, miR (show MLXIP Proteins)-200c, and the transcription factors Nfib (show NFIB Proteins) and Myb (show MYB Proteins), adding new players to the regulatory mechanisms driven by Nkx2-1 in lung epithelial cells that may have implications in lung development and tumorigenesis.

  2. A population of neural stem cells in the ventral region of the adult ventricular-subventricular zone expresses the transcription factor Nkx2.1 and is derived from Nkx2.1-expressing (Nkx2.1+) embryonic precursors.

  3. We conclude that a dedicated subset of VMHVL neurons marked by ERalpha (show ESR1 Proteins), NKX2-1, and Tac1 (show TAC1 Proteins) regulates estrogen-dependent fluctuations in physical activity and constitutes one of several neuroendocrine modules that drive sex-specific responses.

  4. Prototypic GPe neurons derive from the medial ganglionic eminence of the embryonic subpallium and express the transcription factor Nkx2-1. These neurons fire at high rates during alert rest, and encode movements through heterogeneous firing rate changes.

  5. Molecular characterization of disseminated tumor cells indicates that downregulation of the transcription factor Nkx2-1 precedes lung adenocarcinoma dissemination.

  6. The Nkx2-1-mediated pathway in the DMH (show DST Proteins) and LH stimulates skeletal muscle function via the sympathetic nervous system and maintains youthful physiology, contributing to the delay in aging and life span extension.

  7. MicroRNA-33a mediates the regulation of high mobility group AT-hook 2 gene (HMGA2) by thyroid transcription factor 1 (TTF-1/NKX2-1).

  8. A review of recent findings with special attention given to the role of NKX2-1 in lung development and carcinogenesis.

  9. we report the generation of transgenic mouse lines that overexpress wild-type p23 (show CDK5R1 Proteins) or uncleavable p23 (show CDK5R1 Proteins)

  10. Apc (show APC Proteins) and TGF-beta (show TGFB1 Proteins) signaling have roles in regulating the key transcriptional factor, Nkx2.1, for lung epithelial progenitor cell fate determination

NK2 Homeobox 1 (NKX2-1) Protein Profile

Protein Summary

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.

Gene names and symbols associated with NK2 Homeobox 1 Proteins (NKX2-1)

  • thyroid transcription factor 1 (titf1-A)
  • NK2 homeobox 1 (NKX2-1)
  • thyroid transcription factor 1 (LOC100227803)
  • NK2 homeobox 1 (Nkx2-1)
  • prostaglandin E synthase 3 (cytosolic) (Ptges3)
  • thyroid transcription factor 1-like (LOC100154384)
  • 5730442A20Rik protein
  • AV026640 protein
  • BCH protein
  • BHC protein
  • cPGES protein
  • LOC100227803 protein
  • NK-2 protein
  • NKX2-1 protein
  • Nkx2.1 protein
  • NKX2A protein
  • p23 protein
  • Ptges protein
  • sid3177 protein
  • T/EBP protein
  • Tebp protein
  • Titf1 protein
  • titf1-A protein
  • Ttf-1 protein
  • TTF1 protein
  • Xnkx-2.1 protein

Protein level used designations for NK2 Homeobox 1 Proteins (NKX2-1)

thyroid transcription factor 1 , NK2 homeobox 1 , NK-2 homolog A , homeobox protein NK-2 homolog A , homeobox protein Nkx-2.1 , thyroid nuclear factor 1 , thyroid-specific enhancer-binding protein , tinman , TTF-1 , thyroid transcription factor 1 TTF-1 NK-2 , thyroid transcription factor-1 , homeodomain protein NKx2.1 , cytosolic prostaglandin E2 synthase , hsp90 co-chaperone , p23 cochaperone , progesterone receptor complex p23 , prostaglandin E synthase 3 , sid 3177 , telomerase binding protein, p23 , telomerase-binding protein p23

GENE ID SPECIES
373626 Xenopus laevis
452867 Pan troglodytes
100227803 Taeniopygia guttata
7080 Homo sapiens
21869 Mus musculus
25628 Rattus norvegicus
403940 Canis lupus familiaris
395322 Gallus gallus
56351 Mus musculus
100154384 Sus scrofa
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