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NDRG1 is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. Additionally we are shipping N-Myc Downstream Regulated 1 Proteins (18) and N-Myc Downstream Regulated 1 Kits (9) and many more products for this protein.
Showing 10 out of 174 products:
Human Polyclonal NDRG1 Primary Antibody for ICC, IF - ABIN4338332
Schilling, Hjelmeland, Radiloff, Liu, Wakeman, Fielhauer, Foster, Lathia, Rich, Wang, Datto: NDRG4 is required for cell cycle progression and survival in glioblastoma cells. in The Journal of biological chemistry 2009
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Human Monoclonal NDRG1 Primary Antibody for IF, IHC (p) - ABIN564518
Leth-Larsen, Lund, Hansen, Laenkholm, Tarin, Jensen, Ditzel: Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry. in Molecular & cellular proteomics : MCP 2009
Show all 2 Pubmed References
Arabidopsis thaliana Polyclonal NDRG1 Primary Antibody for IHC - ABIN966642
Century, Shapiro, Repetti, Dahlbeck, Holub, Staskawicz: NDR1, a pathogen-induced component required for Arabidopsis disease resistance. in Science (New York, N.Y.) 1997
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Arabidopsis thaliana Polyclonal NDRG1 Primary Antibody for IHC - ABIN966641
Coppinger, Repetti, Day, Dahlbeck, Mehlert, Staskawicz: Overexpression of the plasma membrane-localized NDR1 protein results in enhanced bacterial disease resistance in Arabidopsis thaliana. in The Plant journal : for cell and molecular biology 2004
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Human Polyclonal NDRG1 Primary Antibody for IHC (p), IHC - ABIN268580
Zhou, Salnikow, Costa: Cap43, a novel gene specifically induced by Ni2+ compounds. in Cancer research 1998
we demonstrated that the novel molecule of cell migration and invasion, caveolin-1, has direct interaction with NDRG1 in human colorectal cancer cells
strong NDRG1 expression in ciliated epithelial cells in nasal tissues sampled from patients with chronic rhinosinusitis. NDRG1 gene knockdown decreased the transepithelial electrical resistance and increased the dextran permeability. NDRG1 knockdown disrupted tight junctions of airway epithelial cells. NDRG1 knockdown significantly decreased only claudin-9 (show CLDN9 Antibodies) expression, but did not decrease other claudin family molecules.
Study elucidates a mechanism of NDRG1-regulated Wnt (show WNT2 Antibodies) pathway activation and EMT (show ITK Antibodies) via affecting TLE2 (show TLE2 Antibodies) and beta-catenin (show CTNNB1 Antibodies) expression in esophageal cancer cells.
NDRG1 prevented the degradation of c-Myc (show MYC Antibodies) through Skp2-mediated ubiquitination in tumor cells. NDRG1 directly interacted with Skp2, and decreased phosphorylation of Skp2 through inactivation of CDK2 (show CDK2 Antibodies).
Data suggest that NDRG1 attenuates oncogenic signaling by inhibiting formation of EGFR (show EGFR Antibodies)/HER2 (show ERBB2 Antibodies) and HER2 (show ERBB2 Antibodies)/HER3 (show ERBB3 Antibodies) heterodimers and by down-regulating EGFR (show EGFR Antibodies) via a mechanism involving its degradation. (NDRG1 = N-myc downstream regulated gene 1 protein; EGFR (show EGFR Antibodies) = epidermal growth factor receptor (show EGFR Antibodies); HER = human epidermal growth factor receptor (show EGFR Antibodies)) [REVIEW]
NDR1 interacts with TRAF3 and interferes with the association of TRAF3 and IL-17R, resulting in increased formation of the activation complex IL-17R-Act1, which is required for the downstream signaling and production of pro-inflammatory factors
NDRG1 overexpression leads to reduced tumor growth and angiogenesis in experimental glioma via upregulation of TNFSF15. In NDRG1 overexpressing glioma antiangiogenic treatment does not yield a therapeutic response.
The current study is the first to elucidate a unique facet of the potent tumor/metastasis suppressor NDRG1 in the regulation of pancreatic ductal adenocarcinoma (PDAC)glycolysis, leading to important insights into the mechanism by which NDRG1 exert inhibitory function in PDAC.
The mean nerve NDRG1 expression score was 5.4.
Hereditary motor and sensory neuropathy-type Lom in 12 Czech patients, carrying NDRG1 mutation and one unusual case due to uniparental isodisomy of chromosome 8 has been reported.
NDR1 (show STK38 Antibodies) kinase, activated by the Rap1 (show TERF2IP Antibodies) signaling cascade through RAPL (show RASSF5 Antibodies) and Mst1 (show MST1 Antibodies)/Mst2 (show STK3 Antibodies), associated with and recruited kindlin-3 (show FERMT3 Antibodies) to the immunological synapses, which was required for high-affinity LFA-1 (show ITGAL Antibodies)/ICAM-1 (show ICAM1 Antibodies) binding.
Snell, GHKRO, and PAPPA (show PAPPA Antibodies)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT (show MGMT Antibodies)) and N-myc downstream-regulated gene 1 (NDRG1).
NDRG1 deficiency attenuates the differentiation of macrophage lineage cells, suppressing bone remodeling and inflammatory angiogenesis. This study strongly suggests the crucial role of NDRG1 in differentiation process for macrophages.
Using double knockout of NDR1 (show STK38 Antibodies) and 2 shows that NDRs acted downstream of MST1 (show MST1 Antibodies) to mediate the egress of mature thymocytes from the thymus, as well as the interstitial migration of naive T cells within popliteal lymph nodes.
Ndrg1 is phosphorylated and degraded by CD28 (show CD28 Antibodies) signalling in a proteasome-dependent manner.
Ndr1 (show STK38 Antibodies)/2-double null embryos show defects in somitogenesis and cardiac looping, which reveals their essential functions and shows that the NDR (show STK38 Antibodies) kinases are critically required during the early phase of organogenesis
Rassf5 (show RASSF5 Antibodies) and Ndr1 (show STK38 Antibodies) or Ndr2 (show STK38L Antibodies) kinases regulate neuronal polarity through Par3 (show F2RL2 Antibodies) phosphorylation.
NDRG1 promotes fetal growth and regulates the metabolic response to intrauterine hypoxic injury in a sexually dichotomous manner
early growth response 1 (show EGR1 Antibodies), a transcription factor that binds to the NDRG1 promoter, was mediated in the NDRG1 expression regulation by PKD2 (show PKD2 Antibodies).
NDR1 plays a broad role both in mediating primary cellular functions in Arabidopsis through maintaining the integrity of the cell wall-plasma membrane connection and as a key signaling component of these responses during pathogen infection.
SR1 plays an important role in plant immunity and ethylene signaling by directly regulating NDR1 and EIN3.
The induction of defence responses and disease resistance to X. campestris pv. campestris strain 8004 requires NDR1 , RAR1 and SGT1b, suggesting that effector-triggered immunity plays a large role in resistance to this strain.
Sequence analysis and mass spectrometry suggest that NDR1 (show STK38 Antibodies) is localized to the PM via a C-terminal glycosylphosphatidyl-inositol (GPI (show GPI Antibodies)) anchor.
demonstrate that the RIN4-NDR1 interaction occurs on the cytoplasmically localized N-terminal portion of NDR1 and that this interaction is required for the activation of resistance signaling following infection by P. syringae
Mutations in NDR1 (show STK38 Antibodies) abolished the enhanced resistance of dnd (show DND1 Antibodies) mutants against Pseudomonas syringae pv. tomato and Hyaloperonospora parasitica but not Botrytis cinerea.
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
N-myc downstream-regulated gene 1 protein
, differentiation-related gene 1 protein
, nickel-specific induction protein Cap43
, protein NDRG1
, protein regulated by oxygen-1
, reducing agents and tunicamycin-responsive protein
, N-myc downstream regulated 1
, protein Ndr1
, N-myc downstream regulated gene 1
, protein NDRG1-B
, protein NDRG1-like