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NKD2 encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. Additionally we are shipping Naked Cuticle Homolog 2 (Drosophila) Antibodies (49) and many more products for this protein.
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data indicate that zebrafish Nkd1 (show NKD1 Proteins) and Nkd2 function to limit both canonical and non-canonical Wnt (show WNT2 Proteins) signaling
studies provide compelling evidence that downregulation of NKD2 expression and alterations in associated regulated pathways have a significant role in driving OS tumor growth and metastasis
Mouse naked cuticle 2 (mNkd2) is a direct transcriptional target of Hoxc8 (show HOXC8 Proteins) in vivo.
NKD2 is frequently methylated in human breast cancer, and the expression of NKD2 is regulated by promoter region methylation.
NKD2 methylation is associated with cell differentiation, TNM (show ODZ1 Proteins) stage and distant metastasis significantly (all P < 0.05), and the overall survival time is longer in NKD2 unmethylated group compared to NKD2 methylated group (P < 0.05).
NKD2 antagonizes Wnt signaling: myristoylated NKD2 interacts with Dvl-1 at the plasma membrane, and this interaction leads to their mutual ubiquitin-mediated proteasomal degradation.
NKD2 represents a candidate target of 5p amplifications in soft tissue sarcomas and might play a crucial role during the progression of this disease.
Naked2 acts as a cargo recognition and targeting (CaRT) protein to ensure proper delivery, tethering, and fusion of TGF-alpha (show TGFA Proteins)-containing vesicles to a distinct region at the basolateral surface of polarized epithelial cells.
identify an EGFR (show EGFR Proteins)-independent action of TGF-alpha (show TGFA Proteins), in which it protects Naked2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells
This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
naked cuticle homolog 2
, protein naked cuticle homolog 2-like
, naked cuticle 1 homolog
, protein naked cuticle homolog 2
, Dvl-binding protein NKD2
, naked cuticle 2 homolog
, naked 2a