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Naked Cuticle Homolog 2 (Drosophila) Proteins (NKD2)

NKD2 encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. Additionally we are shipping Naked Cuticle Homolog 2 (Drosophila) Antibodies (52) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NKD2 72293 Q8VE28
NKD2 85409 Q969F2
Rat NKD2 NKD2 308068  
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Top Naked Cuticle Homolog 2 (Drosophila) Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$3,131.33
Details

NKD2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Naked Cuticle Homolog 2 (Drosophila) (NKD2) Interaction Partners

Zebrafish Naked Cuticle Homolog 2 (Drosophila) (NKD2) interaction partners

  1. data indicate that zebrafish Nkd1 (show NKD1 Proteins) and Nkd2 function to limit both canonical and non-canonical Wnt (show WNT2 Proteins) signaling

Mouse (Murine) Naked Cuticle Homolog 2 (Drosophila) (NKD2) interaction partners

  1. studies provide compelling evidence that downregulation of NKD2 expression and alterations in associated regulated pathways have a significant role in driving OS tumor growth and metastasis

  2. Mouse naked cuticle 2 (mNkd2) is a direct transcriptional target of Hoxc8 (show HOXC8 Proteins) in vivo.

Human Naked Cuticle Homolog 2 (Drosophila) (NKD2) interaction partners

  1. NKD2 is frequently methylated in human breast cancer, and the expression of NKD2 is regulated by promoter region methylation.

  2. NKD2 methylation is associated with cell differentiation, TNM (show ODZ1 Proteins) stage and distant metastasis significantly (all P < 0.05), and the overall survival time is longer in NKD2 unmethylated group compared to NKD2 methylated group (P < 0.05).

  3. NKD2 antagonizes Wnt signaling: myristoylated NKD2 interacts with Dvl-1 at the plasma membrane, and this interaction leads to their mutual ubiquitin-mediated proteasomal degradation.

  4. NKD2 represents a candidate target of 5p amplifications in soft tissue sarcomas and might play a crucial role during the progression of this disease.

  5. Naked2 acts as a cargo recognition and targeting (CaRT) protein to ensure proper delivery, tethering, and fusion of TGF-alpha (show TGFA Proteins)-containing vesicles to a distinct region at the basolateral surface of polarized epithelial cells.

  6. identify an EGFR (show EGFR Proteins)-independent action of TGF-alpha (show TGFA Proteins), in which it protects Naked2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells

Naked Cuticle Homolog 2 (Drosophila) (NKD2) Protein Profile

Protein Summary

This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with NKD2

  • naked cuticle homolog 2b (nkd2b)
  • naked cuticle 2 homolog (Drosophila) (Nkd2)
  • naked cuticle homolog 2 (Drosophila) (NKD2)
  • naked cuticle homolog 2 (Drosophila) (Nkd2)
  • naked cuticle homolog 2a (nkd2a)
  • 2210403L10Rik protein
  • AW212591 protein
  • Naked2 protein
  • nkd2 protein
  • nkd2l protein

Protein level used designations for NKD2

naked cuticle homolog 2 , protein naked cuticle homolog 2-like , mNkd2 , naked cuticle 1 homolog , naked-2 , protein naked cuticle homolog 2 , Dvl-binding protein NKD2 , naked cuticle 2 homolog , naked 2a

GENE ID SPECIES
794221 Danio rerio
72293 Mus musculus
85409 Homo sapiens
308068 Rattus norvegicus
100049175 Danio rerio
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