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Nanog Homeobox Proteins (NANOG)

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Additionally we are shipping Nanog Homeobox Antibodies (363) and Nanog Homeobox Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NANOG 71950 Q80Z64
NANOG 79923 Q9H9S0
Rat NANOG NANOG 414065  
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Top Nanog Homeobox Proteins at antibodies-online.com

Showing 10 out of 23 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$808.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,795.83
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
$2,812.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 7 to 9 Days
$328.21
Details
HOST_Escherichia coli (E. coli) Human TAT tag   0.005 mg Log in to see 2 to 3 Days
$178.75
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   0.005 mg Log in to see 2 to 3 Days
$178.75
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$467.86
Details

NANOG Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
, ,

Top referenced Nanog Homeobox Proteins

  1. Human NANOG Protein expressed in Escherichia coli (E. coli) - ABIN667930 : Pan, Pei: Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog. in Cell research 2004 (PubMed)
    Show all 2 references for ABIN667930

More Proteins for Nanog Homeobox (NANOG) Interaction Partners

Mouse (Murine) Nanog Homeobox (NANOG) interaction partners

  1. Nanog is able to transform normal somatic cells into tumor cells.

  2. NANOG represses mitochondrial oxidative phosphorylation genes, as well as reactive oxygen species generation, and activates fatty acid oxidation to support tumor initiating cell self-renewal and drug resistance.

  3. The cellular reprogramming-promoting function of mitoflashes occurs via the upregulation of Nanog expression.

  4. the existence of three stable steady states for Nanog levels, which are the same in all the different conditions of the cell-culture medium.

  5. NANOG binds to GLI1 (show GLI1 Proteins) and GLI3 (show GLI3 Proteins) proteins and represses Hedgehog (show SHH Proteins)-mediated transcription.

  6. Tgif1 counterbalances the activity of core pluripotency factors, Oct4, Sox2, and Nanog, in mouse embryonic stem cells.

  7. TLR4 (show TLR4 Proteins) signaling via NANOG cooperates with STAT3 (show STAT3 Proteins) to activate Twist1 (show TWIST1 Proteins) and promote formation of tumor-initiating stem-like cells in livers of mice.

  8. Pluripotency transcription factors Nanog and Oct4 (show POU5F1 Proteins) positively modulate Sod2 (show SOD2 Proteins) gene transcription in induced pluripotent stem cells.

  9. NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers

  10. Forced expression of Nanog (and Esrrb) resulted in the dispensability of nucleostemin (show E2IG3 Proteins) expression in embryonic stem cells.

Human Nanog Homeobox (NANOG) interaction partners

  1. the disruption of Nanog expression results in less proliferation, invasiveness, migration, more chemosensitivity and reversal of EMT in HepG2 cells, by which Nanog plays crucial roles in influencing the malignant phenotype of HepG2 cells.

  2. The promoter activity of Nanog and Oct4 (show POU5F1 Proteins) were upregulated, and beta-catenin (show CTNNB1 Proteins) was observed to bind to these promoters during H. pylori infection, while a Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) inhibitor suppressed promoter activity and binding.

  3. ectopic expression of Oct-4 (show POU5F1 Proteins) gene in hAFMSCs with high self-renewal ability could upregulate Nanog and Sox-2 (show SOX2 Proteins) gene expression

  4. Nanog is an oncogene (show RAB1A Proteins) with multiple roles in promoting tumorigenesis and metastasis

  5. The positive correlation among Oct-4 (show POU5F1 Proteins), Nanog, and beta-catenin (show CTNNB1 Proteins) suggests their coordinated role in maintaining proliferation in oral carcinoma cells.

  6. Oct3/4 (show POU5F1 Proteins) and Nanog represent probable CSC markers in HNSCC, which contribute to the development of DNM (show DNM1 Proteins) in part by enhancing cell motility and invasiveness.

  7. The outcomes of this study, for the first time, unravels the importance of particular genomic features in Nanog gene evolution paving roads toward better understanding of stem cell development and human targeted disorder therapy

  8. Magnetofection-mediated NANOG delivery increased proliferation and enhanced the differentiation of hair follicle derived mesenchymal stem cells into smooth muscle cells.

  9. NANOG potentiates the molecular circuitry of tumorigenesis, and thus may represent a novel therapeutic target or biomarker for the diagnosis, prognosis, and treatment outcome of cancer.

  10. NANOG may play a significant role in carcinogenesis via its activation of c-Jun (show JUN Proteins) expression.

Pig (Porcine) Nanog Homeobox (NANOG) interaction partners

  1. the functional porcine NANOG that is different in chromosomal structure from mouse and human genes is a single exon gene and encodes the functional NANOG protein.

  2. Results demonstrate that Nanog could interact with and activate other pluripotent genes both in porcine fetal fibroblasts and embryos.

  3. Localisation of NANOG, OCT4 (show POU5F1 Proteins), and E-CADHERIN (show CDH1 Proteins) in porcine pre- and peri (show PLIN1 Proteins)-implantation embryos.

Cow (Bovine) Nanog Homeobox (NANOG) interaction partners

  1. analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos

  2. Nanog displayed relatively the same methylation levels between sperm and oocytes

  3. Noggin, a cytokine inhibiting the BMP4 pathway, successfully upregulated the relative expression of NANOG mRNA in the ICM explants with respect to controls.

Nanog Homeobox (NANOG) Protein Profile

Protein Summary

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).

Gene names and symbols associated with Nanog Homeobox Proteins (NANOG)

  • Nanog homeobox (Nanog)
  • Nanog homeobox (NANOG)
  • 2410002E02Rik protein
  • ecat4 protein
  • ENK protein

Protein level used designations for Nanog Homeobox Proteins (NANOG)

ES cell-associated protein 4 , early embryo specific expression NK family , early embryo specific expression NK-type homeobox protein , homeobox protein NANOG , homeobox transcription factor Nanog , hNanog , homeobox transcription factor Nanog-delta 48 , homeodomain transcription factor Nanog , homeobox transcription factor NANOG

GENE ID SPECIES
71950 Mus musculus
79923 Homo sapiens
100170132 Sus scrofa
538951 Bos taurus
486701 Canis lupus familiaris
100860956 Capra hircus
414065 Rattus norvegicus
748301 Pan troglodytes
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