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Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue. Additionally we are shipping and many more products for this protein.
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Human Polyclonal NMBR Primary Antibody for WB - ABIN2787710
Matusiak, Glover, Nathaniel, Matkowskyj, Yang, Benya: Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. in American journal of physiology. Gastrointestinal and liver physiology 2005
In sow estrous cycle, the hypothalamic levels of both NMB and NMBR mRAN were similar, but the expression levels of the pituitary were negatively correlated.
The rs2717 and rs6926279 within the NMBR gene were associated with schizophrenia liability.
Hypoxia regulates the expression of the neuromedin B receptor through a mechanism dependent on hypoxia-inducible factor-1alpha.
NMB and its receptor are coexpressed by proliferating cells in which they act in an autocrine fashion with similar and modest potency in both normal and malignant colonic epithelial cells.
NMB or NMBR silencing inhibited M-CSF (show CSF1R Antibodies)/c-Fms (show CSF1R Antibodies)-mediated downstream signaling pathways like activation of ERK (show EPHB2 Antibodies) and Akt (show AKT1 Antibodies) and induction of D-type cyclins, cyclin D1 (show CCND1 Antibodies) and D2.
mice with deletion of NB receptor have lower insulinemia, especially in response to oral glucose, and females also exhibited a better glucose tolerance, suggesting the involvement of neuromedin b and its receptor in regulation of insulin (show INS Antibodies) secretion induced by incretins, and also, in insulin (show INS Antibodies) sensitivity.
ablating NMB receptor-expressing neurons eliminated basal and hypoxia-induced sighing, but left breathing otherwise intact initially
The neuromedin B pathways are importantly involved in secretory pathways of TSH and revealed its participation in the in vivo regulation of gene expression of TSH beta (show TSHB Antibodies)-subunit (show POLG Antibodies) and pituitary MCT8 (show MCT8 Antibodies) and Thrb (show THRB Antibodies) and hypothalamic TRH (show TRH Antibodies) and type 2 deiodinase (show DIO2 Antibodies).
Together, we define the respective function of NMBR and GRPR (show GRPR Antibodies) in itch transmission, and reveal an unexpected relationship not only between the two receptors but also between the two populations of interneurons in itch signaling.
spinal GRPr (show GRPR Antibodies) and NMBr independently drive itch neurotransmission in mice.
Results implicate that NMB is involved in cartilage development, either in an autocrine or paracrine manner.
The data demonstrated that the neuromedin B-neuromedian B receptor interaction in pregnant myometrial primary cells in vitro predominantly influenced uterine activity through regulation of Il6 (show IL6 Antibodies) expression via the Rela/p65 (show NFkBP65 Antibodies) pathway.
These data demonstrate that neuromedin B and its receptor can induce the onset of labor via a RELA (show NFkBP65 Antibodies)/IL6 (show IL6 Antibodies)-mediated pathway.
The mRNA and protein expressions of NMBR reach a peak at the onset of labor.
Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.
neuromedin B receptor
, neuromedin-B receptor
, epididymis tissue protein Li 185a
, neuromedin-B-preferring bombesin receptor