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NXF1 is one member of a family of nuclear RNA export factor genes. Additionally we are shipping NXF1 Kits (23) and NXF1 Proteins (5) and many more products for this protein.
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small hairpin RNA-mediated down-regulation of TAP or Aly (show THOC4 Antibodies) reduced nuclear export of HDAg-L and assembly of HDV virions. Furthermore, a peptide, TAT (show TAT Antibodies)-HDAg-L(198-210), containing the 10-amino acid TAT (show TAT Antibodies) peptide and HDAg-L(198-210), inhibited the interaction between HDAg-L and TAP and blocked HDV virion assembly and secretion.
Hepatitis B virus core protein associates with the cellular NXF1-p15 (show CDKN2B Antibodies) complex via the nuclear export signal motif of hepatitis B virus core protein.Nuclear export of human hepatitis B virus core protein and pregenomic RNA depends on the NXF1-p15 (show CDKN2B Antibodies) machinery.
Complementary structural, biochemical and cellular techniques indicated that the formation of a symmetric RNA binding platform generated by dimerization of NXF1:NXT1 (show NXT1 Antibodies) facilitates the recognition of CTE-RNA and promotes its nuclear export
Gag polyprotein synthesis was decreased by NXF1 knockdown.
a spatial map is produced in living cells of the sites for the interaction of two TREX subunits, Alyref (show THOC4 Antibodies) and Chtop (show CHTOP Antibodies), with Nxf1.
TREX is the major complex used to recruit Nxf1 to mRNA in human cells.
the organization of the NXF1 proline-tyrosine nuclear localization signal reveal unexpected redundancy in the nuclear import pathways used by NXF1.
The U2AF65 protein ser (show U2AF59 Antibodies)ved as an adaptor to link expanded CAG RNA to NXF1 for RNA export.
these data revealed a redox-regulated chaperone function of PDI in delivering antigenic peptides from TAP to MHC-I.
Tpr plays an important role in quality control of mRNA trafficked on the Nxf1 pathway.
Taken together, the results show for the first time that murine leukemia virus requires the Tap/NXF1-mediated export pathway for the expression of its spliced and unspliced RNAs and for full-legth RNA nuclear export.
Disruption of NXF1 expression impaired cytoplasmic accumulations of both spliced and unspliced RNA transcripts of Murine leukemia virus.
Perturbation of U2AF65 (show U2AF59 Antibodies)/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases.
RNA transport element RTE evolved as a high affinity RBM15 (show RBM15 Antibodies) ligand to provide a splicing-independent link to NXF1, thereby ensuring efficient nuclear export and expression of retrotransposon transcripts
FMRP (show FMR1 Antibodies) and Nxf2 (show NXF2 Antibodies) associate with and destabilize Nxf1 mRNA in neuronal cells.
CAST allele of Nxf1 suppresses IAP (show ALPI Antibodies)-Idelta1 insertions in Ap3d1 (show AP3D1 Antibodies)[mh2J], Atcay (show ATCAY Antibodies)[hes (show ATCAY Antibodies)], Mgrn1 (show MGRN1 Antibodies)[md] and Usp14[axJ]. Does not suppress the Mitf (show MITF Antibodies)[mi-bw (show MITF Antibodies)] LINE nor any of six tested ETn insertion alleles.
The RNA-binding motif protein 15B (RBM15B/OTT3 (show RBM15B Antibodies)) acts as cofactor of the nuclear export receptor NXF1.
Allelic variation in Nxf1 suppresses RNA processing defects in IAP (show ALPI Antibodies) insertion alleles of Pitpn (vibrator (show PITPNA Antibodies)) and Eya1 (show EYA1 Antibodies) (branchio-oto (show PGAP1 Antibodies)-renal syndrome).
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants.
nuclear RNA export factor 1
, small bristles
, Nuclear RNA export factor 1
, nuclear RNA export factor 1-like
, mRNA export factor TAP
, tip associating protein
, tip-associated protein
, tip-associating protein
, Mex 67 homolog
, modifier of vibrator 1
, nuclear RNA export factor 1 homolog
, tip associated protein