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The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm.
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The role of gp210/Nup210 in cell differentiation is mediated by its large luminal domain.
Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor (show LIF Antibodies) low affinity receptor, in ligand binding and receptor activation
Expression of gp210 mRNA and protein was seen in mouse embryonic stem (ES) cells, supporting the view of cell-type specific NPCs in metazoans and suggesting the gp210 gene is regulated by specific control elements not shared by other nucleoporins.
gp210 cannot be required for incorporation of proteins or be required for maintaining nuclear pore complex stability.
WT1 (show WT1 Antibodies) is probably not regulating GP210 expression, in spite of binding sites for WT1 (show WT1 Antibodies)
gp210 plays critical roles at the nuclear membrane
Quantitation of serusm anti-gp210-C-terminal peptide antibodies is useful for monitoring the effect of ursodeoxycholic acid and for the early identification of patients at high risk for end-stage hepatic failure.
The increased expression of gp210 in small bile ducts is possibly involved in autoimmune response to gp210 leading to the progression to end-stage hepatic failure in primary biliary cirrhosis .
Double knockdowns of gp210 in HeLa cells suggest that nuclear pore complexes can assemble or at least persist in a gp210-free form.
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex.
nuclear envelope pore membrane protein POM 210
, nuclear pore membrane glycoprotein 210
, nuclear pore membrane protein 210
, nuclear pore protein gp210
, nucleoporin 210; nuclear pore membrane glycoprotein 210; nuclear pore membrane protein 210
, nucleoporin Nup210
, pore membrane protein of 210 kDa