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Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. Additionally we are shipping Nucleoredoxin Antibodies (39) and Nucleoredoxin Proteins (11) and many more products for this protein.
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These results reveal a novel role of NRX in the regulation of PFK1 activity and in the balance between glycolysis and the pentose phosphate pathway.
NRX retains a pool of inactive Dishevelled (show DVL2 ELISA Kits) for robust activation of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling upon Wnt (show WNT2 ELISA Kits) stimulation.
Nucleoredoxin negatively regulates Toll-like receptor 4 (show TLR4 ELISA Kits) signaling via recruitment of flightless-I to myeloid differentiation primary response (show GADD45B ELISA Kits) gene
These data suggest a relationship between the Wnt (show WNT2 ELISA Kits)-beta-catenin (show CTNNB1 ELISA Kits) pathway and redox signalling through redox-sensitive association of NRX with Dvl (show DVL1 ELISA Kits).
formation of a complex between GST-nucleoredoxin, protein phosphatase 2A (PP2A) (C) and PP2A(D) was demonstrated by pull-down experiments
identified nucleoredoxin as an interaction partner of Sec63 (show SEC63 ELISA Kits); characterized this interaction; Sec63 (show SEC63 ELISA Kits) is linked to the Wnt (show WNT2 ELISA Kits) signaling pathways and this interaction may be the reason why mutations in SEC63 (show SEC63 ELISA Kits) can lead to polycystic liver disease
Nucleoredoxin is a novel thioredoxin (show TXN ELISA Kits) family member involved in cell growth and differentiation [review]
Nucleoredoxin regulates the Wnt (show WNT2 ELISA Kits)/planar cell polarity pathway in Xenopus.
Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).
, nucleoredoxin-like 2
, protein Red-1
, nucleoredoxin 1