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NDEL1 encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Additionally we are shipping NDEL1 Proteins (7) and many more products for this protein.
Showing 10 out of 113 products:
NDEL1 facilitates the reversal of somatodendritic traansport in the proximal axon.
study provided comprehensive documentation of the expression patterns of Nde1 and Ndel1 in cultured cells as well as in mouse and human brains, and also highlighting that dosage effects of these two proteins might contribute to some cases of mental disorder
Results suggest that NDEL1 might interact with DISC1 (show DISC1 Antibodies) to activate ERK (show EPHB2 Antibodies) signaling and function as a potential protective factor during the spontaneous seizure period after pilocarpine-induced status epilepticus
Results show that LIS1 (show PAFAH1B1 Antibodies) acts via the LIS1 (show PAFAH1B1 Antibodies)-NDEL1-dynein complex to regulate astral microtubule MT plus-ends dynamics and establish proper contacts of MTs (show NEU2 Antibodies) with the cell cortex to ensure precise cell division.
Nuclear distribution element-like 1 (Ndel1 or Nudel) was firstly described as a regulator of the cytoskeleton in microtubule and intermediate filament dynamics and microtubule-based transport.
Expressing a mutant Ndel1 lacking key phosphorylation sites shuts down organelle transport completely in axons.
palmitoylated Ndel1 reduced cytoplasmic dynein (show DYNC1H1 Antibodies) activity as judged by Golgi distribution, VSVG and short microtubule trafficking, transport of endogenous Ndel1 and LIS1 (show PAFAH1B1 Antibodies) from neurite tips to the cell body and neuronal migration
Lis1 (show PAFAH1B1 Antibodies) and Ndel1 are essential for normal cortical neuronal migration, neurite outgrowth, and function of the microtubule organizing center in a dose-dependent manner.
The predicted peptide product resulting from the Scottish translocation removes the interaction domain for Nudel. Nudel is able to act as a bridge between DISC1 (show DISC1 Antibodies) and Lis1 (show PAFAH1B1 Antibodies) to allow formation of a trimolecular complex.
NUDEL is important for NF assembly, transport and neuronal integrity. NUDEL facilitates the polymerization of NFs through a direct interaction with the NF light subunit (NF-L (show NEFL Antibodies)).
Study showed that Ndel1 enzyme activity is a complex trait influenced by many different genetic variants that may contribute to schizophrenia physiopathology
This study observed a significantly increased myelin basic protein (MBP (show MBP Antibodies)) and nuclear distribution protein nudE-like 1 (NDEL1) mRNA levels in FEP patients compared with controls.
The Plasma Ndel1 enzyme activity is reduced in patients with schizophrenia.
Short (DISC)1 (show DISC1 Antibodies) splice variants show reduced or no binding to nudE nuclear distribution E homolog (NDEL)1 and phosphodiesterase (PDE (show ALDH7A1 Antibodies))4B proteins, but fully interact with FEZ1 (show LZTS1 Antibodies) and glycogen synthase kinase 3 (GSK3)beta (show GSK3b Antibodies).
Nudel markedly promotes the HSPC300 (show BRK1 Antibodies)-WAVE2 (show WASF2 Antibodies) interaction.
analysis of mixed NDE1-NDEL1 complexes demonstrates that NDE1 and NDEL1 can interact directly.
Cytosolic mfGbeta is recruited to dynein by Nudel and transported to the centrosome for rapid sequestration and degradation.
Studies indicate that binding of dynactin (show DCTN1 Antibodies), LIS1 (show PAFAH1B1 Antibodies) and NudEL regulate cytoplasmic dynein (show DYNC1H1 Antibodies) motor activity.
DISC1 (show DISC1 Antibodies) forms octamers via dimers as building blocks. S704C forms higher-order oligomers, without affecting its affinity with NDEL1
This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X.
nudE nuclear distribution gene E homolog (A. nidulans)-like 1
, nuclear disribution gene E like
, nuclear distribution protein nudE-like 1
, protein Nudel
, endooligopeptidase A
, mitosin-associated protein 1
, mitosin-associated protein MITAP1
, nudE nuclear distribution E homolog-like 1
, nudE nuclear distribution gene E homolog-like 1
, nudE nuclear distribution gene E homolog like 1
, endooligopeptidase A protein
, LIS1-interacting protein NUDEL
, LIS1-interacting protein NUDEL; endooligopeptidase A
, nuclear distribution gene E-like homolog 1