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anti-Numb Homolog (Drosophila)-Like (NUMBL) Antibodies

Plays a role in the process of neurogenesis. Additionally we are shipping Numb Homolog (Drosophila)-Like Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NUMBL 9253 Q9Y6R0
NUMBL 292732  
NUMBL 18223 O08919
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Top anti-Numb Homolog (Drosophila)-Like Antibodies at antibodies-online.com

Showing 10 out of 60 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB NUMBL Antibody (C-term) (ABIN658002) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the NUMBL antibody detected the NUMBL protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p) IHC-P Image NUMBL antibody [N1], N-term detects Numb-R protein at cytoplasm on human placenta by immunohistochemical analysis. Sample: Paraffin-embedded placenta. NUMBL antibody [N1], N-term , dilution: 1:100. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IHC (p), ELISA Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Goat Un-conjugated IHC, ELISA   100 μg Log in to see 8 to 10 Days
$581.17
Details
Mouse Rabbit Un-conjugated IHC, WB 200 μL Log in to see 9 Days
$588.50
Details
Human Rabbit Un-conjugated IP   100 μL Log in to see 8 to 10 Days
$815.83
Details
Human Rabbit Un-conjugated IP   100 μL Log in to see 8 to 10 Days
$815.83
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated WB   50 μL Log in to see 8 to 10 Days
$463.83
Details

NUMBL Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Numb Homolog (Drosophila)-Like Antibodies

  1. Human Polyclonal NUMBL Primary Antibody for IHC (p), WB - ABIN658002 : Zhou, Ma, Shi, Huo: NUMBL interacts with TRAF6 and promotes the degradation of TRAF6. in Biochemical and biophysical research communications 2010 (PubMed)
    Show all 2 references for ABIN658002

More Antibodies against Numb Homolog (Drosophila)-Like Interaction Partners

Xenopus laevis Numb Homolog (Drosophila)-Like (NUMBL) interaction partners

  1. Results show an essential role of NumbL during Xenopus primary neurogenesis and provide evidence for a Notch (show NOTCH1 Antibodies)-independent function of NumbL.

Human Numb Homolog (Drosophila)-Like (NUMBL) interaction partners

  1. Numb/Numbl control VEGF receptor (show FLT1 Antibodies) endocytosis, signaling, and recycling in endothelial cells, which promotes the angiogenic growth of blood vessels.

  2. Numbl might be involved in the inhibition of growth, proliferation, and invasion of 95-D lung cancer cells.

  3. Numbl-Klf4 (show KLF4 Antibodies) signaling is critical to maintain multiple nodes of metastatic progression, including persistence of cancer-initiating cells.

  4. data suggest that Numbl regulates glioma cell migration and invasion by abrogating TRAF5 (show TRAF5 Antibodies)-induced activation of NF-KappaB (show NFKB1 Antibodies)

  5. NUMBL interacts with TRAF6 (show TRAF6 Antibodies) and promotes the degradation of TRAF6 (show TRAF6 Antibodies) in vivo, leading to the inhibition of NF-kappaB (show NFKB1 Antibodies) signaling pathway.

  6. Both gene sequence alterations and amplifications of LNX1 (show LNX1 Antibodies) and Numbl are present in a subset of human gliomas.

Mouse (Murine) Numb Homolog (Drosophila)-Like (NUMBL) interaction partners

  1. findings demonstrate that Nb and Nbl are intrinsic factors crucial for the renewal of CPCs in the PA2 and that the PA2 serves as a microenvironment for their expansion

  2. Numb/Numbl control VEGF receptor (show FLT1 Antibodies) endocytosis, signaling, and recycling in endothelial cells, which promotes the angiogenic growth of blood vessels.

  3. By ablating Numb (show NUMB Antibodies) and Numbl in different cardiac populations followed by lineage tracing, we determined that Numb (show NUMB Antibodies) and Numbl in the second heart field are required for outflow tract (OFT) and atrioventricular septation and OFT alignment.

  4. Concomitant but not separate ablation of Numb (show NUMB Antibodies) and Numblike in the developing heart leads to increased Notch2 (show NOTCH2 Antibodies) activity along with hypertrabeculation, reduced compaction, and ventricular septum defects.

  5. Numbl is a physiologically relevant target of miR (show MLXIP Antibodies)-34a in neural progenitor cells, allowing for enhanced Notch (show NOTCH1 Antibodies) signaling and inhibition of neuronal differentiation.

  6. the data demonstrate that Numb (show NUMB Antibodies) and Numblike have evolved to acquire at least partially distinct functions.

  7. mouse numb (show NUMB Antibodies) and numblike play redundant but critical roles in maintaining neural progenitor cells during embryogenesis, by allowing their progenies to choose progenitor over neuronal fates

  8. Numblike plays an essential role in the control of cortical morphogenesis, a process requiring precise regulation of neural progenitor cell proliferation, differentiation, and apoptosis.

  9. evidence for previously unidentified functions of Numb (show NUMB Antibodies) and Numblike in sensory axon arborization by regulating Notch1 (show NOTCH1 Antibodies) via the endocytic-lysosomal pathways

  10. Removal of Numb/Numblike from postnatal SVZ progenitors and ependymal cells resulted in severe damage to brain lateral ventricle integrity and identified roles for Numb/Numblike in regulating ependymal wall integrity and SVZ neuroblast survival.

Numb Homolog (Drosophila)-Like (NUMBL) Antigen Profile

Protein Summary

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

Gene names and symbols associated with NUMBL

  • numb homolog (Drosophila)-like (NUMBL) antibody
  • numb homolog-like (numbl) antibody
  • numb homolog (Drosophila)-like (Numbl) antibody
  • numb-like (Numbl) antibody
  • CAG3A antibody
  • CTG3a antibody
  • NBL antibody
  • numb antibody
  • NUMB-R antibody
  • NUMBLIKE antibody
  • NUMBR antibody
  • TNRC23 antibody

Protein level used designations for NUMBL

numb homolog-like , numb-like protein , numb-related protein

GENE ID SPECIES
100068203 Equus caballus
100462918 Xenopus laevis
9253 Homo sapiens
292732 Rattus norvegicus
612491 Canis lupus familiaris
510973 Bos taurus
18223 Mus musculus
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