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anti-O-Linked N-Acetylglucosamine (GlcNAc) Transferase (UDP-N-Acetylglucosamine:polypeptide-N-Acetylglucosaminyl Transferase) (OGT) Antibodies

OGT encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Additionally we are shipping OGT Proteins (5) and OGT Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
OGT 26295 P56558
OGT 8473 O15294
OGT 108155 Q8CGY8
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Top anti-OGT Antibodies at antibodies-online.com

Showing 10 out of 84 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-OGT Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human heart Host: Rabbit  Target Name: OGT  Sample Tissue: 721_B Whole Cell lysates  Antibody Dilution: 1.0 µg/mL OGT is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of OGT antibody (C-term) (ABIN390649) in mouse bladder tissue lysates (35 µg/lane). OGT (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with OGT Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Goat Un-conjugated ELISA, WB ABIN190863 (0.05µg/ml) staining of Rat Pancreas lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of OGT antibody (C-term) in mouse bladder tissue lysates (35ug/lane). OGT (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Dog Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Dog Goat Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- OGT Picoband antibody,IHC(P) IHC(P): Mouse Intestine Tissue Anti- OGT Picoband antibody,IHC(P) IHC(P): Rat Intestine Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ICC, IF, IP, IHC (p), WB WB Image O-GlcNAc transferase antibody detects O-GlcNAc transferase protein by western blot analysis. Mouse tissue extracts (50 μg) was separated by 7.5 % SDS-PAGE, and blotted with O-GlcNAc transferase antibody , diluted by 1:2000 WB Image O-GlcNAc transferase antibody detects O-GlcNAc transferase protein by western blot analysis. A. 30 μg 293T whole cell extract B. 30 μg A431 whole cell extract C. 30 μg HeLa whole cell extract D. 30 μg HepG2 whole cell extract 5 % SDS-PAGE O-GlcNAc transferase antibody , dilution: 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Whole cell extract (30 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with O-GlcNAc transferase antibody [N1N2], N-term , diluted at 1:1000. IHC-P Image O-GlcNAc transferase antibody [N1N2], N-term detects O-GlcNAc transferase protein at cytosol on mouse liver by immunohistochemical analysis. Sample: Paraffin-embedded mouse liver. O-GlcNAc transferase antibody [N1N2], N-term , dilution: 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with OGT antibody ABIN337257 at 5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details

OGT Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)
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Mouse (Murine)
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Top referenced anti-OGT Antibodies

  1. Human Polyclonal OGT Primary Antibody for EIA, WB - ABIN453239 : Fujiki, Chikanishi, Hashiba, Ito, Takada, Roeder, Kitagawa, Kato: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. in Nature 2009 (PubMed)
    Show all 3 references for ABIN453239

  2. Human Polyclonal OGT Primary Antibody for IHC (p), WB - ABIN390649 : Taylor, Geisler, Chambers, McClain: Up-regulation of O-GlcNAc transferase with glucose deprivation in HepG2 cells is mediated by decreased hexosamine pathway flux. in The Journal of biological chemistry 2009 (PubMed)
    Show all 3 references for ABIN390649

  3. Chicken Polyclonal OGT Primary Antibody for WB - ABIN2783662 : Taylor, Parker, Hazel, Soesanto, Fuller, Yazzie, McClain: Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase. in The Journal of biological chemistry 2008 (PubMed)

  4. Dog (Canine) Polyclonal OGT Primary Antibody for WB - ABIN374838 : Majumdar, Wright, Markowitz, Martinez-Hernandez, Raghow, Solomon: Insulin stimulates and diabetes inhibits O-linked N-acetylglucosamine transferase and O-glycosylation of Sp1. in Diabetes 2004 (PubMed)

More Antibodies against OGT Interaction Partners

Fruit Fly (Drosophila melanogaster) O-Linked N-Acetylglucosamine (GlcNAc) Transferase (UDP-N-Acetylglucosamine:polypeptide-N-Acetylglucosaminyl Transferase) (OGT) interaction partners

  1. Here is presented a novel O-GlcNAc transferase (OGT), EOGT (show C3orf64 Antibodies), responsible for extracellular O-linked-N-acetylglucosamine acylation.

  2. study found that the super sex combs (sxc)gene encodes O-linked N-acetylglucosamine transferase (Ogt); Polycomb (show CBX2 Antibodies) repression appears to be a critical function of Sxc/Ogt in Drosophila and may be mediated by the glycosylation of Polyhomeotic

Zebrafish O-Linked N-Acetylglucosamine (GlcNAc) Transferase (UDP-N-Acetylglucosamine:polypeptide-N-Acetylglucosaminyl Transferase) (OGT) interaction partners

  1. Developmental regulation of zOGT transcriptional variants generated by alternative splicing and characterization of their OGT activities of protein O-GlcNAcylation.

  2. Overexpression of Ogt delayed epiboly and caused a severe disorganization of the microtubule and actin based cytoskeleton in the extra-embryonic yolk syncytial layer.

Cow (Bovine) O-Linked N-Acetylglucosamine (GlcNAc) Transferase (UDP-N-Acetylglucosamine:polypeptide-N-Acetylglucosaminyl Transferase) (OGT) interaction partners

  1. Hsp90 is involved in the regulation of OGT and O-GlcNAc modification and that Hsp90 inhibitors might be used to modulate O-GlcNAc modification and reverse its adverse effects in human diseases.

Human O-Linked N-Acetylglucosamine (GlcNAc) Transferase (UDP-N-Acetylglucosamine:polypeptide-N-Acetylglucosaminyl Transferase) (OGT) interaction partners

  1. We concluded that OGT plays a key role in gastric cancer proliferation and survival, and could be a potential target for therapy.

  2. Data suggest RNA polymerase II (POLR2A (show POLR2A Antibodies)) is extensively modified on its unique C-terminal domain (CTD) by O-GlcNAc transferase (OGT); efficient O-GlcNAcylation requires a minimum of 20 heptad CTD repeats in POLR2A (show POLR2A Antibodies) and more than half of NTD of OGT.

  3. Together, these findings suggest that induction of SNO (show SKIL Antibodies)-OGT by Ab exposure is a pathogenic mechanism to cause cellular hypo-O-GlcNAcylation by which Ab neurotoxicity is executed

  4. These results suggested roles of O-GlcNAcylation in modulating serine phosphorylation, as well as in regulating PKM2 activity and expression.

  5. These results demonstrate that distinct OGT-binding sites in HCF-1 (show HCFC1 Antibodies) promote proteolysis, and provide novel insights into the mechanism of this unusual protease activity.

  6. This work reveals that although the N-terminal TPR repeats of OGT may have roles in substrate recognition, the sequence restriction imposed by the peptide-binding site makes a substantial contribution to O-GlcNAc site specificity.

  7. OGT expression is increased under hypoxic conditions.

  8. E2F1 (show E2F1 Antibodies) negatively regulates both Ogt and Mgea5 (show MGEA5 Antibodies) expression in an Rb1 (show RB1 Antibodies) protein-dependent manner.

  9. Inhibition of O-Linked N-Acetylglucosamine Transferase Reduces Replication of Herpes Simplex Virus and Human Cytomegalovirus.

  10. miR4235p was associated with congestive heart failure and the expression levels of proBNP; in addition, OGT was found to be a direct target of miR4235p.

Pig (Porcine) O-Linked N-Acetylglucosamine (GlcNAc) Transferase (UDP-N-Acetylglucosamine:polypeptide-N-Acetylglucosaminyl Transferase) (OGT) interaction partners

  1. Data suggest that enzymes in hexosamine biosynthesis pathway and downstream protein O-GlcNAcylation are important for preimplantation development (show MTA2 Antibodies); these include Ogt, Gfpt (glutamine (show GFPT1 Antibodies)-fructose-6-P aminotransferase), and Oga (O-GlcNAcase (show MGEA5 Antibodies)).

Mouse (Murine) O-Linked N-Acetylglucosamine (GlcNAc) Transferase (UDP-N-Acetylglucosamine:polypeptide-N-Acetylglucosaminyl Transferase) (OGT) interaction partners

  1. OGT overexpression increased the level of OGA (show MGEA5 Antibodies), suggesting a compensatory mechanism for the aberrant O-GlcNAcylation.

  2. O-GlcNAc transferase is at least partially required for maintaining cellular proliferative and migratory capacities of cardiomyocytes

  3. E2F1 (show E2F1 Antibodies) negatively regulates both Ogt and Mgea5 (show MGEA5 Antibodies) expression in an Rb1 (show RB1 Antibodies) protein-dependent manner.

  4. The hyperphagia derived from the paraventricular nucleus of the hypothalamus, where loss of OGT was associated with impaired satiety.

  5. 26S proteasome (show Psmd4 Antibodies)-mediated OGT reduction contributed to hypoxia-induced vascular endothelial inflammatory response.

  6. Glucosamine-induced OGT activation mediates glucose production through cleaved Notch1 (show NOTCH1 Antibodies) and FoxO1 (show FOXO1 Antibodies), which contributes to the regulation of maintenance of self-renewal in mouse embryonic stem cells.

  7. Study shows that OGT expression is enriched in hypothalamic AgRP (show AGRP Antibodies) neurons and induced by fasting and ghrelin (show GHRL Antibodies). Pharmacogenetical activation of AgRP (show AGRP Antibodies) neurons suppresses the thermogenic program in white fat (WAT), while the selective knockout of Ogt in AgRP (show AGRP Antibodies) neurons inhibits neuronal activity, promotes WAT browning, and protects mice against diet-induced obesity.

  8. OGT serves as a key placental biomarker and functions as an important mediator of the maternal changes occurring in response to stress.

  9. cardiomyocyte-specific OGT KO mice had dilated hearts, signs of heart failure and low viability.

  10. Treatment with GlcN, in contrast, inhibits LPS (show TLR4 Antibodies)-ind inflammation and decreased LPS (show TLR4 Antibodies)-mediated recruitment of OGT, mSin3A, and HDACs.

OGT Antigen Profile

Protein Summary

This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene names and symbols associated with OGT

  • O-linked N-acetylglucosamine (GlcNAc) transferase (ogt) antibody
  • super sex combs (sxc) antibody
  • O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1 (ogt.1) antibody
  • O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) antibody
  • O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) (OGT) antibody
  • O-linked GlcNAc transferase (GL50803_12081) antibody
  • O-linked GlcNAc transferase (GL50803_41701) antibody
  • o-linked GlcNAc transferase (THAPSDRAFT_264441) antibody
  • O-linked GlcNAc transferase (spyA) antibody
  • O-linked N-acetylglucosamine (GlcNAc) transferase (Ogt) antibody
  • O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) (Ogt) antibody
  • 1110038P24Rik antibody
  • 4831420N21Rik antibody
  • AI115525 antibody
  • BcDNA:GH04245 antibody
  • CG10392 antibody
  • Dmel\\CG10392 antibody
  • fm81g08 antibody
  • HRNT1 antibody
  • l(2)02637 antibody
  • l(2)NC130 antibody
  • O-GLCNAC antibody
  • ogt antibody
  • Ogtl antibody
  • P1201 antibody
  • Sxc antibody
  • sxc/Ogt antibody
  • wu:fc12b01 antibody
  • wu:fm81g08 antibody

Protein level used designations for OGT

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) , O-linked GlcNAc transferase , UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase , CG10392-PA , CG10392-PB , CG10392-PC , O-glycosyltransferase , O-linked N-acetylglucosamine transferase , lethal (2) NC130 , sxc-PA , sxc-PB , sxc-PC , O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 1 , copy I , ogta , UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit , o-linked GlcNAc transferase , TPR repeat-containing protein , UDP-N-acetylglucosamine:peptide N-acetylglucosaminyltransferase , O linked N-acetylglucosamine transferase , O-GlcNAc transferase subunit p110 , O-linked N-acetylglucosamine transferase 110 kDa subunit , UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase , O-GlcNAc transferase p110 subunit , uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase , O linked N-acetylglucosamine transferase like , UDP-N-acetylglucosaminyltransferase

GENE ID SPECIES
447694 Xenopus laevis
35486 Drosophila melanogaster
337685 Danio rerio
422203 Gallus gallus
532053 Bos taurus
553157 Xenopus (Silurana) tropicalis
698268 Macaca mulatta
5700203 Giardia lamblia ATCC 50803
5700847 Giardia lamblia ATCC 50803
7453152 Thalassiosira pseudonana CCMP1335
8625015 Dictyostelium discoideum AX4
26295 Rattus norvegicus
8473 Homo sapiens
480955 Canis lupus familiaris
664652 Sus scrofa
100354727 Oryctolagus cuniculus
108155 Mus musculus
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