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Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import (By similarity).. Additionally we are shipping and many more products for this protein.
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Human Polyclonal ORAI3 Primary Antibody for EIA, IF - ABIN500427
Lewis: Calcium signaling mechanisms in T lymphocytes. in Annual review of immunology 2001
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Human Polyclonal ORAI3 Primary Antibody for EIA, IF - ABIN500425
Soboloff, Spassova, Dziadek, Gill: Calcium signals mediated by STIM and Orai proteins--a new paradigm in inter-organelle communication. in Biochimica et biophysica acta 2006
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Human Polyclonal ORAI3 Primary Antibody for IHC (fro), IF - ABIN318923
Feske, Gwack, Prakriya, Srikanth, Puppel, Tanasa, Hogan, Lewis, Daly, Rao: A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. in Nature 2006
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results identified the ORAI-NOX2 (show CYBB Antibodies) feedback loop as a determinant of monocyte immune responses.
Overall high Orai3/Orai1 (show ORAI1 Antibodies) ratios in human prostate epithelial cells and androgen-insensitive cancer cells contribute to their ROS (show ROS1 Antibodies) resistance and thereby may have a share in making the prostate one of the most prominent cancer susceptible organs
A channel chimera of Orai3 with the N terminus of Orai1 (show ORAI1 Antibodies) was able to couple local Ca(2 (show CA2 Antibodies)+) entry to NFAT (show NFATC1 Antibodies) activation, identifying the N-terminal domain of Orai1 (show ORAI1 Antibodies) as central to Ca(2 (show CA2 Antibodies)+) nanodomain-transcription coupling.
Orai3 down-tunes efficient STIM1 (show STIM1 Antibodies) gating when in a heteromeric complex with Orai1 (show ORAI1 Antibodies).
The higher amplitude of store-operated Ca2 (show CA2 Antibodies)+ entry was associated to the over-expression for Stim2 (show Stim2 Antibodies), Orai2 (show ORAI2 Antibodies)-3, and TRPC1 (show TRPC1 Antibodies) while Stim2 (show Stim2 Antibodies) levels remained constant and Stim1 (show STIM1 Antibodies), Orai1 (show ORAI1 Antibodies), Orai3, TRPC1 (show TRPC1 Antibodies) and TRPC4 (show TRPC4 Antibodies) proteins were over-expressed in primary myelofibrosis.
Orai3 constitutes a native store-operated calcium entry pathway in non small cell lung adenocarcinoma that controls cell proliferation and cell cycle progression, likely via Akt (show AKT1 Antibodies) pathway.
Orai1 (show ORAI1 Antibodies) and Orai3 proteins are more important than calcium influx to control cell proliferation.
High ORAI3 expression is associated with breast cancer.
data establish Orai3 as an ERalpha (show ESR1 Antibodies)-regulated channel and a potential selective therapeutic target for ERalpha (show ESR1 Antibodies)(+) breast cancers
the N-terminal conserved region plays a multifaceted role in Orai3 current gating with distinct structural requirements for STIM1 (show STIM1 Antibodies)- and 2-APB (show RNPEP Antibodies)-stimulated activation.
VEGF (show VEGFA Antibodies) signaling via arachidonic acid and arachidonic acid metabolism causes Orai3 to accumulate at the cell surface to mediate Ca(2 (show CA2 Antibodies)+) entry and downstream endothelial cell remodeling.
Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import (By similarity).
, ORAI calcium release-activated calcium modulator 3
, transmembrane protein 142C
, calcium release-activated calcium channel 3
, calcium release-activated calcium modulator 3 protein